Women rule

Bullard, M. Kelley; Bir, Natasha D.; Kwan, Rita O.; Cureton, Elizabeth L.; Knudson, Peggy; Harken, Alden H.

doi:10.1016/j.surg.2009.04.033

Cited by 12 publications

(7 citation statements)

References 12 publications

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“…In fact, female gender was demonstrated to be a risk factor for death in head injured patients [33]. The hypothesis that female sex hormones may be protective has led to the suggestion by some authors that exogenous estradiol could be considered as a therapeutic agent in the trauma room [34,35]. This approach might be questioned considering the literature where some studies show that the a d c b Fig.…”

Section: Discussionmentioning

confidence: 99%

Time dependent influence of host factors on outcome after trauma

et al. 2012

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The impact of host factors, such as gender and co-morbidity, on mortality after trauma has been debated. Quantification of risk factors is dependent on methodological considerations including follow-up time, definitions and adjustment of potential confounders. Optimal follow-up time of trauma patients remains to be elucidated. We investigated the impact of gender and co-morbidity on short and long term mortality in a cohort including 4,051 patients from a level 1 trauma centre. Data from the trauma cohort were linked to validated national registries. 30 and 360-day survival were analysed with logistic and Cox regression, respectively. Long term survival was also estimated as standardized mortality ratio, which implies a comparison with a matched general population. The influence of host factors on outcome after trauma differed over time. Male gender was an independent risk factor for mortality at 1 year but not at 30-days post-injury, even after adjustment for clinically relevant confounders. This gender difference was also apparent when comparing mortality rates with the general population. Moreover, the effect of gender seems to be restricted to elderly patients. The presence of co-morbidity became a significant risk factor beyond 30 days after trauma, suggesting that this patient group may benefit from a more thorough follow up after hospital discharge. A persistent excess mortality compared to the general population was still seen 1 year after the trauma. Our findings indicate that the effect of trauma is not limited to the early post-injury period but adversely affects the long term outcome.

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Section: Discussionmentioning

confidence: 99%

Time dependent influence of host factors on outcome after trauma

et al. 2012

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“…The apparent discrepancy between clinical studies and the laboratory studies in animals suggests caution in instituting trials with the administration of estrogen to injured patients. 7,33 In 1997, Baue opinioned as to why there were no magic bullets for the treatment of systemic inflammatory response syndrome and MOF. 34 Perhaps some of the problems in developing novel therapies for injured patients with diverse demographics and injuries and genetic predisposition outside of gender are equally important today.…”

Section: Discussionmentioning

confidence: 99%

Estrogen Impairs Pulmonary Microvascular Response to Gut-Derived Mediators After Shock Conditions

Diebel

Liberati

2011

Journal of Trauma: Injury, Infection &Amp; Critical Care

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“…1 Similarly, women enjoy better overall survival compared with men with similarly staged colorectal cancer (CRC). 2 We postulate that unique genotypic machinery promoting epigenetic alterations, such as the creation of Barr bodies and immunosurveillance augmented by fetal cell microchimerism, rather than hormones or environmental risk factors, protect women from dying of CRC relative to men.…”

Section: Hypothesismentioning

confidence: 99%