Wolbachia limits pathogen infections through induction of host innate immune responses

Zhang, Donghui; Wang, Yingfan; He, Kun; Yang, Qing-Gui; Gong, Maoqing; Ji, Minjun; Chen, Lin

doi:10.1371/journal.pone.0226736

Cited by 27 publications

(20 citation statements)

References 52 publications

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“…Wolbachia contains a type 4 secretion system, which may secrete specific compounds impacting host biology and regulating the interaction between Wolbachia and other bacteria ( 47 – 49 ). Second, endosymbionts can induce host immune responses (such as antimicrobial peptides) which in turn may regulate bacterial diversity ( 50 – 52 ). Transinfected Wolbachia strains can upregulate the host's immune response ( 53 , 54 ).…”

Section: Discussionmentioning

confidence: 99%

Endosymbionts Reduce Microbiome Diversity and Modify Host Metabolism and Fecundity in the Planthopper Sogatella furcifera

Zhou

Wang

et al. 2022

mSystems

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Endosymbionts can profoundly affect the nutrition, immunity, development, and reproduction of insect hosts, but the effects of multiple endosymbiont infections on microbiota and the interaction of these effects with insect host fitness are not well known. By establishing S. furcifera lines with different endosymbiont infection status, we found that Cardinium and the combined Cardinium + Wolbachia infections differentially reduced bacterial diversity as well as changing bacterial community structure and affecting metabolism, which may connect to negative fitness effects of the endosymbionts on their host.

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Section: Discussionmentioning

confidence: 99%

Endosymbionts Reduce Microbiome Diversity and Modify Host Metabolism and Fecundity in the Planthopper Sogatella furcifera

Zhou

Wang

et al. 2022

mSystems

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“…Our previous study also observed a higher emergence of Wolbachia-infected offspring than that of uninfected offspring when the wasps emerged from A. pernyi eggs (Zhou et al, 2020). One potential explanation is that Wolbachia protect hosts against a broad range of pathogens by induction of host innate immune responses or competing with pathogens for nutrients (Brownlie and Johnson, 2009;Zhang et al, 2020). Some studies doubted that the abortion of Trichogramma offspring may be caused by the vertical transmitted pathogens like Nosema spp.…”

Section: Discussionmentioning

confidence: 89%

Effects of Thelytokous Parthenogenesis-Inducing Wolbachia on the Fitness of Trichogramma dendrolimi Matsumura (Hymenoptera: Trichogrammatidae) in Superparasitised and Single-Parasitised Hosts

et al. 2021

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Thelytokous Wolbachia-infected Trichogramma species have long been considered as biological control agents against lepidopteran pests in agriculture and forestry. Wolbachia has been suggested to increase the probability of the superparasitism of Trichogramma, but the fate of infected offspring in the superparasitised host is still unknown. The present study aimed to evaluate the fitness of thelytokous Wolbachia-infected (TDW) and bisexual Wolbachia-free (TD) Trichogramma dendrolimi Matsumura (Hymenoptera: Trichogrammatidae) lines in superparasitised or single-parasitised hosts. The results showed that irrespective of whether Trichogramma wasps were developed from superparasitised or single-parasitised hosts, the TDW line was characterized by reduced fitness, including lower fecundity, shorter longevity, and smaller body size of F1 offspring, and lower emergence rate of F2 offspring than the TD line. This was not true for the survival rate and developmental time of F1 offspring. Additionally, the fitness parameters of T. dendrolimi that developed from superparasitised hosts were lower compared with that of T. dendrolimi that developed from single-parasitised hosts. Interestingly, Wolbachia-infected females had higher dispersal capacity than bisexual females when they developed from superparasitised hosts. The results indicated that Wolbachia negatively affects fitness of T. dendrolimi, but enhance dispersal capacity of T. dendrolimi females in superparasitism condition. Further studies need to be carried out to select the best line that will allow Wolbachia and their host Trichogramma to be better adapted to one another.

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“…The study showed that the w AlbB infection in mosquitoes activates both IMD and Toll pathways and infection is maintained through maternal transmission (MT) [ 192 ]. Another study also showed that Wolbachia boosts immune responses and increase mosquitoes’ resistance to viruses, which allows the immune system to actively fight against the viruses in the arthropod host [ 193 ]. In a study series of blood-feeding mosquito trials in response to the human host, it was shown that as mosquitoes infected with w MelPop- Wolbachia strain age, they feed less compared to their uninfected counterparts as a result of the observed bent proboscis.…”

Section: Wolbachia-based Field and Experimental Studiesmentioning

confidence: 99%

A Review: Aedes-Borne Arboviral Infections, Controls and Wolbachia-Based Strategies

et al. 2021

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Arthropod-borne viruses (Arboviruses) continue to generate significant health and economic burdens for people living in endemic regions. Of these viruses, some of the most important (e.g., dengue, Zika, chikungunya, and yellow fever virus), are transmitted mainly by Aedes mosquitoes. Over the years, viral infection control has targeted vector population reduction and inhibition of arboviral replication and transmission. This control includes the vector control methods which are classified into chemical, environmental, and biological methods. Some of these control methods may be largely experimental (both field and laboratory investigations) or widely practised. Perceptively, one of the biological methods of vector control, in particular, Wolbachia-based control, shows a promising control strategy for eradicating Aedes-borne arboviruses. This can either be through the artificial introduction of Wolbachia, a naturally present bacterium that impedes viral growth in mosquitoes into heterologous Aedes aegypti mosquito vectors (vectors that are not natural hosts of Wolbachia) thereby limiting arboviral transmission or via Aedes albopictus mosquitoes, which naturally harbour Wolbachia infection. These strategies are potentially undermined by the tendency of mosquitoes to lose Wolbachia infection in unfavourable weather conditions (e.g., high temperature) and the inhibitory competitive dynamics among co-circulating Wolbachia strains. The main objective of this review was to critically appraise published articles on vector control strategies and specifically highlight the use of Wolbachia-based control to suppress vector population growth or disrupt viral transmission. We retrieved studies on the control strategies for arboviral transmissions via arthropod vectors and discussed the use of Wolbachia control strategies for eradicating arboviral diseases to identify literature gaps that will be instrumental in developing models to estimate the impact of these control strategies and, in essence, the use of different Wolbachia strains and features.

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Wolbachia limits pathogen infections through induction of host innate immune responses

Cited by 27 publications

References 52 publications

Endosymbionts Reduce Microbiome Diversity and Modify Host Metabolism and Fecundity in the Planthopper Sogatella furcifera

Endosymbionts Reduce Microbiome Diversity and Modify Host Metabolism and Fecundity in the Planthopper Sogatella furcifera

Effects of Thelytokous Parthenogenesis-Inducing Wolbachia on the Fitness of Trichogramma dendrolimi Matsumura (Hymenoptera: Trichogrammatidae) in Superparasitised and Single-Parasitised Hosts

A Review: Aedes-Borne Arboviral Infections, Controls and Wolbachia-Based Strategies

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