Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells

Anti-Proliferative and Apoptotic Effects of Beta-Ionone in Human Leukemia Cell Line K562

“…It would be compatible with the research by Zhu et al who have studied the effect of β-ionone on in human osteosarcoma (U2os) cells and has showed that this plant-derived compound is able to inhibit cell proliferation [22], also compatible with the research by Jones et al that examined the effect of β-ionone in human prostate tumor cells, and showed that β-ionone inhibited cell proliferation and activates apoptosis via the mitochondrial pathway [23]. In this case, similar observations have been reported in the previous studies with other natural plant products such as lycopene [24,25], silymarin [26], curcumin [27], epigallocatechin-3-gallate [28], celastrol [29], tea polyphenol [30], berberine [31], gossypol [32], wogonin [33], Korean red ginseng extract [34] and Curcuma longa extract [35] in various cancer cell lines. Therefore, beta-ionone and other effective plant-derived materials could be considered as the promising strategy for developing the anticancer drugs.…”

The downregulation of c‑Myc and its target gene hTERT is associated with the antiproliferative effects of baicalin on HL‑60 cells

“…Therefore, perturbation of c-Myc levels is essential for influencing the growth of malignant cells, particularly those of hematopoietic origin (11). Wogonin, another major bioactive flavonoid extracted from Scutellaria baicalensis has been revealed to inhibit HL-60 cell growth via telomerase inhibition through suppression of c-Myc (12). Due to the similar molecular structure between baicalin and wogonin (Fig.…”

Natural products against hematological malignancies and identification of their targets

“…Here we focused on the potential anti-leukemia effects of wogonin. It was shown that wogonin potently induces apoptotic cell death in leukemic HL-60 cells by increasing the expression of pro-apoptotic Bax protein and decreasing that of the anti-apoptotic myeloid cell leukemia 1 (Mcl-1) protein [84] and inhibiting the expression of human telomerase reverse transcriptase, telomerase-associated protein 1 and Myc mRNA, thereby down-regulating telomerase activity [85]. Recently, wogonin was also reported to induce the expression of certain members of the endoplasmic reticulum (ER) stress pathway and the activation of multiple branches of ER stress transducers, which are possibly mediated by the inhibition of the phosphoinositide 3-kinase/Akt signaling pathway [86].…”