Anti-Proliferative and Apoptotic Effects of Beta-Ionone in Human Leukemia Cell Line K562

Abstract

Background: Beta-ionone is an aroma compound found in the Rosaceae family. Some evidence supported that beta-ionone has a great potential for cancer prevention. To date, the anti-proliferative and apoptotic effects of beta-ionone in human leukemia cell line K562 were not studied.

β-Ionone Attenuates Dexamethasone-Induced Suppression of Collagen and Hyaluronic Acid Synthesis in Human Dermal Fibroblasts

“…It is also approved as a flavoring ingredient in food by the Food and Drug Administration (FDA). Previous studies revealed that this compound has antioxidant capacity and anti-proliferative and pro-apoptotic effects on several cell lines, such as human lung epithelial cells and leucocytes [ 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. In the present work, we aimed to investigate whether β-ionone attenuates the dexamethasone-induced suppression of collagen and hyaluronic acid synthesis, and we delineated the mechanisms involved.…”

Effect of Rosa pimpinellifolia Extract on Human Tumor Cells Proliferation

“…Cancer is a major public health problem worldwide, and approximately 10 million new cases are detected annually (Faezizadeh et al, 2016). There are various traditional treatment options, such as surgery, radiotherapy, and chemotherapy, to treat cancer.…”

“…As one of the most commonly used treatments, chemotherapy has been in clinic for about 70 years for the purpose of suppressing cancer cell proliferation (Demir et al, 2019). However, toxicity of chemotherapeutics on normal cells and drug resistance on cancer cells affect the success percentage of chemotherapy (Faezizadeh et al, 2016). The worldwide high incidence of cancer and disadvantages of chemotherapy necessitates the development of new clinical strategies (Abotaleb et al, 2020).…”

“…Increasing evidence supports the potential use of some phytochemicals that can kill cancer cells by modulating the expression of metabolic enzymes (Zhang, 2015). In recent years, the plant extracts with low toxicity on normal cells and with greater effect on cancer cells have led the scientific community to investigate the anticancer properties of herbal products (Faezizadeh et al, 2016;Zarei and Yaghoobi, 2019). Because natural products are an important source of phytochemicals and other bioactive compounds, they are an important resource for therapeutic products that can prevent or cure a large number of diseases (Mármol et al, 2020).…”