Wnt/β‑catenin signaling modulates piperine‑mediated antitumor effects on human osteosarcoma cells

Qi, Yubin; Yang, Wei-Zhong; Si, Meng; Lin, Na

doi:10.3892/mmr.2020.11000

Cited by 10 publications

(12 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Piperine decreased cell migration by inhibiting the expression of matrix metalloproteinase MMP-2 and MMP-9 and suppressed cell proliferation by inducing cell cycle arrest at the G2/M phase; several signaling pathways were involved in this process [72]. Reduction of the viability of HOS and 143B osteosarcoma cells after treatment with piperine has been reported in other in vitro studies [73] and animal models using Sarcoma 180 cells [74]. Interestingly, the majority of research on the carcinopreventive effect of piperine has been performed in vitro or with animal models [5], although it has been reported that administration of 20 mg of piperine to eight healthy individuals each morning for six days was well-tolerated [75].…”

Section: Piperine and Other Tumorsmentioning

confidence: 65%

Piperine: A Savor Inducer and a Cancer Reducer

Djaldetti¹

2021

OBM HG

View full text Add to dashboard Cite

Spices have been used for many decades, and although new and improved culinary spices have been developed, black pepper (<em>Piper nigrum</em>) continues to retain its distinguished title as the <em>“King of spices”</em> due to its particular pungent taste. An alkaloid called piperine is the main component in black pepper that, besides generating the well-known taste, imparts well-documented immunomodulatory, anti-inflammatory, antimicrobial, antioxidant, and even anti-cancer properties; these properties have led to rigorous research on black pepper. Studies conducted on cancer cell lines and in animal models with tumors revealed that piperine might influence tumor development and metastasis via various pathways, some of which are quite common for most types of malignant processes, while others are associated with a specific type of cancer. In this review, we summarized the effect of piperine on various types of cancer and the mechanism by which it acts as a carcinopreventive agent.

show abstract

Section: Piperine and Other Tumorsmentioning

confidence: 65%

Piperine: A Savor Inducer and a Cancer Reducer

Djaldetti¹

2021

OBM HG

View full text Add to dashboard Cite

show abstract

“…The mechanism underpinning the antiangiogenetic effects of piperine lay in the downregulation of the pro-angiogenetic Akt signaling cascade by piperine [89]. Moreover, piperine decreased the expression of VEGF in osteosarcoma [53] and mouse breast cancer cells [29] (Table 2), further supporting its ability to interfere with the process of neoangiogenesis.…”

Section: Inhibition Of Angiogenesismentioning

confidence: 88%

“…For this reason, its regulation is an attractive target for cancer therapy. Very recent studies reported that inhibition of the Wnt/β-catenin signaling pathway mediates the anticancer effects of piperine in colorectal [39] and osteosarcoma cancer cells [53] (Table 2). In particular, the studies disclosed the central role of β-catenin suppression for the inhibition of Wnt signaling in cancer cells [39].…”

Section: Inhibition Of Invasion/migration and Epithelial Mesenchymal mentioning

confidence: 99%

“…In particular, the studies disclosed the central role of β-catenin suppression for the inhibition of Wnt signaling in cancer cells [39]. The downregulation of β-catenin downstream targets (cyclooxygenase-2 (COX-2), cyclin D1, and c-myc) triggered apoptosis and inhibited cell proliferation and metastasis [53].…”

Section: Inhibition Of Invasion/migration and Epithelial Mesenchymal mentioning

confidence: 99%

See 1 more Smart Citation

Overview of the Anticancer Potential of the “King of Spices” Piper nigrum and Its Main Constituent Piperine

Turrini

Sestili

Fimognari

2020

Toxins

View full text Add to dashboard Cite

The main limits of current anticancer therapy are relapses, chemoresistance, and toxic effects resulting from its poor selectivity towards cancer cells that severely impair a patient’s quality of life. Therefore, the discovery of new anticancer drugs remains an urgent challenge. Natural products represent an excellent opportunity due to their ability to target heterogenous populations of cancer cells and regulate several key pathways involved in cancer development, and their favorable toxicological profile. Piper nigrum is one of the most popular spices in the world, with growing fame as a source of bioactive molecules with pharmacological properties. The present review aims to provide a comprehensive overview of the anticancer potential of Piper nigrum and its major active constituents—not limited to the well-known piperine—whose undeniable anticancer properties have been reported for different cancer cell lines and animal models. Moreover, the chemosensitizing effects of Piper nigrum in association with traditional anticancer drugs are depicted and its toxicological profile is outlined. Despite the promising results, human studies are missing, which are crucial for supporting the efficacy and safety of Piper nigrum and its single components in cancer patients.

show abstract

“…It has been reported that piperine inhibited the growth of cancer cells by arresting the cell cycle and suppressing cell cycle regulators such as cyclin B1 and cyclin D1 expression in human prostate cancer cells and osteosarcoma cells. 35,36 However, further research is needed to elucidate the effects of piperine on the cell cycle and the expression of cell cycle regulators in pancreatic cancer cells.…”

Section: High Performance Liquid Chromatography (Hplc) Analysis Of Pne and Anti-pancreatic Cancer Activities Of Piperine In Panc-1 Human mentioning

confidence: 99%

In Vitro Inhibition of Piper nigrum and Piperine on Growth, Migration, and Invasion of PANC-1 Human Pancreatic Cancer Cells

Jeong

Ryu

Lee

2021

Natural Product Communications

View full text Add to dashboard Cite

Several dietary and medicinal herbs have been shown to be effective in the treatment and prevention of cancer. Although Piper nigrum has been shown to have anti-cancer activities against various cancer cells, its anti-pancreatic cancer properties have not been reported. In the present study, P. nigrum extract (PNE) inhibited proliferation of PANC-1 human pancreatic cancer cells. Flow cytometry showed G0/G1 arrest caused by PNE in PANC-1 cells. In addition, Western blot analysis showed that PNE suppressed the protein levels of cell cycle regulators such as cyclin B1, cyclin D1, survivin, and Forkhead box M1 (FoxM1). These findings suggested that the inhibitory activity of PNE against the growth of PANC-1 cells was correlated with cell cycle arrest and repression of cell cycle regulators. Wound healing and trans-well assays showed that PNE suppressed migration and invasion of PANC-1 cells. Piperine, a major alkaloid of Piper nigrum, was identified as the main component of PNE by HPLC analysis. Piperine also attenuated the cell growth, migration, and invasion of PANC-1 cells, suggesting its contribution to the anti-pancreatic cancer effects of PNE. These results demonstrate that PNE and its major constituent, piperine, have anti-pancreatic cancer properties such as growth-inhibition, anti-migration, and anti-invasion of cancer cells.

show abstract

Wnt/β‑catenin signaling modulates piperine‑mediated antitumor effects on human osteosarcoma cells

Cited by 10 publications

References 40 publications

Piperine: A Savor Inducer and a Cancer Reducer

Piperine: A Savor Inducer and a Cancer Reducer

Overview of the Anticancer Potential of the “King of Spices” Piper nigrum and Its Main Constituent Piperine

In Vitro Inhibition of Piper nigrum and Piperine on Growth, Migration, and Invasion of PANC-1 Human Pancreatic Cancer Cells

Contact Info

Product

Resources

About