Abstract:Spices have been used for many decades, and although new and improved culinary spices have been developed, black pepper (<em>Piper nigrum</em>) continues to retain its distinguished title as the <em>“King of spices”</em> due to its particular pungent taste. An alkaloid called piperine is the main component in black pepper that, besides generating the well-known taste, imparts well-documented immunomodulatory, anti-inflammatory, antimicrobial, antioxidant, and even anti-cancer properties… Show more
“…In addition, piperine has been found to have chemopreventive properties, interfering with the development and progression of cancer [145]. It stimulates the immunomodulatory activities of mononuclear cells by producing anti-inflammatory cytokines and inhibiting pro-inflammatory activities, thereby exerting a pronounced anti-cancer effect [146]. Piperine affects cancer cells via several mechanisms, including the modulation of redox homeostasis, inhibition of cancer stem cell (CSC) self-renewal and the modulation of ER The results of the study highlight the therapeutic potential of these alkaloids in fighting breast cancer by targeting the activation of STAT3, a crucial signaling pathway that plays a role in cancer development [141].…”
Michael acceptors represent a class of compounds with potential anti-cancer properties. They act by binding to nucleophilic sites in biological molecules, thereby disrupting cancer cell function and inducing cell death. This mode of action, as well as their ability to be modified and targeted, makes them a promising avenue for advancing cancer therapy. We are investigating the molecular mechanisms underlying Michael acceptors and their interactions with cancer cells, in particular their ability to interfere with cellular processes and induce apoptosis. The anti-cancer properties of Michael acceptors are not accidental but are due to their chemical structure and reactivity. The electrophilic nature of these compounds allows them to selectively target nucleophilic residues on disease-associated proteins, resulting in significant therapeutic benefits and minimal toxicity in various diseases. This opens up new perspectives for the development of more effective and precise cancer drugs. Nevertheless, further studies are essential to fully understand the impact of our discoveries and translate them into clinical practice.
“…In addition, piperine has been found to have chemopreventive properties, interfering with the development and progression of cancer [145]. It stimulates the immunomodulatory activities of mononuclear cells by producing anti-inflammatory cytokines and inhibiting pro-inflammatory activities, thereby exerting a pronounced anti-cancer effect [146]. Piperine affects cancer cells via several mechanisms, including the modulation of redox homeostasis, inhibition of cancer stem cell (CSC) self-renewal and the modulation of ER The results of the study highlight the therapeutic potential of these alkaloids in fighting breast cancer by targeting the activation of STAT3, a crucial signaling pathway that plays a role in cancer development [141].…”
Michael acceptors represent a class of compounds with potential anti-cancer properties. They act by binding to nucleophilic sites in biological molecules, thereby disrupting cancer cell function and inducing cell death. This mode of action, as well as their ability to be modified and targeted, makes them a promising avenue for advancing cancer therapy. We are investigating the molecular mechanisms underlying Michael acceptors and their interactions with cancer cells, in particular their ability to interfere with cellular processes and induce apoptosis. The anti-cancer properties of Michael acceptors are not accidental but are due to their chemical structure and reactivity. The electrophilic nature of these compounds allows them to selectively target nucleophilic residues on disease-associated proteins, resulting in significant therapeutic benefits and minimal toxicity in various diseases. This opens up new perspectives for the development of more effective and precise cancer drugs. Nevertheless, further studies are essential to fully understand the impact of our discoveries and translate them into clinical practice.
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