Wnt/β‐catenin and ERK pathway activation: A possible mechanism of photobiomodulation therapy with light‐emitting diodes that regulate the proliferation of human outer root sheath cells

Kim, Jung E.; Woo, Young Sup; Sohn, Ki Min; Jeong, Kwan; Kang, Hoon

doi:10.1002/lsm.22736

Cited by 50 publications

(35 citation statements)

References 20 publications

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“…Interestingly, several authors have reported the effects of PBM on signalling molecules involved in this pathway. In their study, Kim et al evaluated the response of human outer root sheath cells to PBM at wavelengths of 415 nm, 525 nm, 660 nm or 830 nm (142). Notably they found that PBM induced an increase in ERK phosphorylation.…”

Section: Extracellular-regulated Kinase (Erk) Signallingmentioning

confidence: 99%

“…Several authors have reported the effects of PBM on p38 MAPK signalling. Interestingly, both Kim et al and Chu et al concluded that red light PBM induced increased p38 phosphorylation and therefore increases in the activity of this pathway (142,144). However, a further study concluded that following application of red light, there was a decrease in p38 phosphorylation (145).…”

Section: P38 Mapksmentioning

confidence: 99%

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Under the spotlight: mechanisms of photobiomodulation concentrating on blue and green light

Serrage

Heiskanen

Palin

et al. 2019

Photochem Photobiol Sci

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Section: Extracellular-regulated Kinase (Erk) Signallingmentioning

confidence: 99%

Section: P38 Mapksmentioning

confidence: 99%

Under the spotlight: mechanisms of photobiomodulation concentrating on blue and green light

Serrage

Heiskanen

Palin

et al. 2019

Photochem Photobiol Sci

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“…Low Level Laser Light Therapy (LLLT) is widely used as alternative medical treatment in wound healing and to relieve pain and inflammation. The effects of light therapy on hair growth have been investigated via DPCs . In addition, electromagnetic field resulted in stimulation of DPCs activity .…”

Section: Hair Growth Promoting Effectmentioning

confidence: 99%

Review of Hair Follicle Dermal Papilla cells asin vitroscreening model for hair growth

Madaan

Verma

Singh

et al. 2018

Intern J of Cosmetic Sci

113

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Hair disorders such as hair loss (alopecia) and androgen dependent, excessive hair growth (hirsutism, hypertrichosis) may impact the social and psychological well-being of an individual. Recent advances in understanding the biology of hair have accelerated the research and development of novel therapeutic and cosmetic hair growth agents. Preclinical models aid in dermocosmetic efficacy testing and claim substantiation of hair growth modulators. The in vitro models to investigate hair growth utilize the hair follicle Dermal Papilla cells (DPCs), specialized mesenchymal cells located at the base of hair follicle that play essential roles in hair follicular morphogenesis and postnatal hair growth cycles. In this review, we have compiled and discussed the extensively reported literature citing DPCs as in vitro model to study hair growth promoting and inhibitory effects. A variety of agents such as herbal and natural extracts, growth factors and cytokines, platelet-rich plasma, placental extract, stem cells and conditioned medium, peptides, hormones, lipid-nanocarrier, light, electrical and electromagnetic field stimulation, androgens and their analogs, stress-serum and chemotherapeutic agents etc. have been examined for their hair growth modulating effects in DPCs. Effects on DPCs' activity were determined from untreated (basal) or stress induced levels. Cell proliferation, apoptosis and secretion of growth factors were included as primary end-point markers. Effects on a wide range of biomolecules and mechanistic pathways that play key role in the biology of hair growth were also investigated. This consolidated and comprehensive review summarizes the up-to-date information and understanding regarding DPCs based screening models for hair growth and may be helpful for researchers to select the appropriate assay system and biomarkers. This review highlights the pivotal role of DPCs in the forefront of hair research as screening platforms by providing insights into mechanistic action at cellular level, which may further direct the development of novel hair growth modulators.

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“…Recent studies pointed out that INH could induce HepG2 cell injury by repressing SIRT1 expression . Extracellular signal‐regulated kinase (ERK) regulates various cellular processes, like cell proliferation, cell differentiation, and cell cycle progression in response to various extracellular signals . INH is believed to induce apoptosis by inhibiting ERK phosphorylation .…”

Section: Introductionmentioning

confidence: 99%

Quercetin protected against isoniazide‐induced HepG2 cell apoptosis by activating the SIRT1/ERK pathway

Zhang

Tao

et al. 2019

J Biochem & Molecular Tox

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Isoniazid (INH) is one of the most commonly used antituberculosis drugs, but its clinical applications have been limited by severe hepatic toxicity. Quercetin (Que), a natural flavonoid, has been proved to have many medicinal properties. This study aimed to clarify the possible protective effects of Que against INH‐induced hepatotoxicity using HepG2 cells. Our results indicated that Que significantly increased cell viability, superoxide dismutase, and GSH levels, while decreased alanine aminotransferase/aspartate aminotransferase levels. Besides, Que significantly abrogated INH‐induced cell apoptosis by upregulating the expression levels of Bcl‐2 and decreasing the levels of Bax, cleaved caspase‐3, and cleaved caspase‐9. Furthermore, Que obviously reversed the inhibition of INH on Sirtuin 1 (SIRT1) expression and extracellular signal‐regulated kinase (ERK) phosphorylation. Next, the SIRT1 inhibitor EX527 blocked the enhancement of Que upon ERK phosphorylation. Notably, EX527 partially abolished the beneficial effects of Que. In brief, our results provided the first evidence that Que protected against INH‐induced HepG2 cells by regulating the SIRT1/ERK pathway.

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Wnt/β‐catenin and ERK pathway activation: A possible mechanism of photobiomodulation therapy with light‐emitting diodes that regulate the proliferation of human outer root sheath cells

Cited by 50 publications

References 20 publications

Under the spotlight: mechanisms of photobiomodulation concentrating on blue and green light

Under the spotlight: mechanisms of photobiomodulation concentrating on blue and green light

Review of Hair Follicle Dermal Papilla cells asin vitroscreening model for hair growth

Quercetin protected against isoniazide‐induced HepG2 cell apoptosis by activating the SIRT1/ERK pathway

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