WNT signaling in atrial fibrillation

Abstract

The Wnt signaling pathway regulates physiological processes such as cell proliferation and differentiation, cell fate decisions, and stem cell maintenance and, thus, plays essential roles in embryonic development, but also in adult tissue homeostasis and repair. The Wnt signaling pathway has been associated with heart development and repair and has been shown to be crucially involved in proliferation and differentiation of progenitor cells into cardiomyocytes. The investigation of the role of the Wnt signaling pathway and the regulation of its expression/activity in atrial fibrillation has only just begun. The present minireview (I) provides original data regarding the expression of Wnt signaling components in atrial tissue of patients with atrial fibrillation or sinus rhythm and (II) summarizes the current state of knowledge of the regulation of Wnt signaling components’ expression/activity and the contribution of the various levels of the Wnt signal transduction pathway to the processes of the development, maintenance, and progression of atrial fibrillation.

Screening and Bioinformatics Analysis of Crucial Gene of Heart Failure and Atrial Fibrillation Based on GEO Database

“…Moreover, our study found that despite the upregulation of the expression of FRZB in the heart tissue of patients with HF and AF, the gene expression of β-catenin downstream of the Wnt pathway was still upregulated. A similar phenomenon was also found in a previous study [ 28 ]. Wolke et al [ 28 ] considered that the up-regulation of FRZB cuts off any potentially harmful signal factor input through the Wnt pathway.…”

The Role of microRNA in the Development, Diagnosis, and Treatment of Cardiovascular Disease: Recent Developments

“…However, miR-200b-3p was upregulated in serum only at baseline and at 12 months. Targets of miR-200b-3p are involved in Wnt signaling pathway, whose dysregulation is known to contribute to the development of AF (Wolke et al, 2021). On the other hand, miR-34a-5p was upregulated at 12 and 24 months, while miR-125b-5p was downregulated at baseline.…”

Dynamic Involvement of Telocytes in Modulating Multiple Signaling Pathways in Cardiac Cytoarchitecture

“…Double GSK3 deletion is associated with mitotic catastrophe, ventricular dysfunction and immoderate cardiac remodeling, finally leading to lethal DCM [ 80 ]. Notably, WNT signaling has been documented to hand out to atrial fibrosis as a hallmark of architectural remodeling during atrial fibrillation [ 81 ]. WNT3a, except for WNT5a, has been revealed to switch on WNT/beta-catenin signaling by expressing the profibrotic target genes within cardiac fibroblasts [ 82 ].…”