Dynamic Involvement of Telocytes in Modulating Multiple Signaling Pathways in Cardiac Cytoarchitecture

Cucu, Ioana; Nicolescu, Mihnea Ioan; Busnatu, Ștefan; Manole, Catalin G.

doi:10.3390/ijms23105769

Cited by 10 publications

(7 citation statements)

References 148 publications

(203 reference statements)

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“…TCs had a particular infrastructural phenotype and expressed abilities to establish homo‐ and heterocellular contacts, and performed three‐dimensional stromal networks inside of tissues/organs such as in lung tissue and thyroid follicles 6 . Cell–cell communication mediated by TCs with various cell types was dependent on crucial modulators of intercellular signaling 45–47 . TCs could interact with stem cells, epithelial cells, fibroblasts, immune cells, neural cells, smooth muscle cells, and endothelial cell types by establishing cell membrane contacts 48 .…”

Section: Discussionmentioning

confidence: 99%

“…6 Cell-cell communication mediated by TCs with various cell types was dependent on crucial modulators of intercellular signaling. [45][46][47] TCs could interact with stem cells, epithelial cells, fibroblasts, immune cells, neural cells, smooth muscle cells, and endothelial cell types by establishing cell membrane contacts. 48 Cell junction had been observed in previously studies.…”

Section: F I G U R Ementioning

confidence: 99%

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Single‐cell RNA sequencing reveals telocytes subsets of human lung

Dai,

Cai,

Wang

et al. 2024

Clinical and Translational Dis

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BackgroundTelocyte (TC) is a recently defined renewed cell and its dominant intercommunication with other cells displays multiple functions in tissue homeostasis and diseases. Alveolar epithelial cells and immune cells were in the lung cancer heterogeneity, progression, and metastasis, and further associated with antitumor therapeutic strategies. However, few studies focus on the roles of TCs in lung cancer.MethodsIn this article, we used the public scRNA‐Seq data (including healthy control, chronic obstructive pulmonary disease, non–small cell lung cancer, lymph node metastases from non–small cell lung cancer, and systemic sclerosis–associated interstitial lung disease patients) to analyze the cellular dynamics in human lung and distinct types of TCs and their communication networks with the variety of cell types.ResultsSix subclusters of TCs were identified by expression of specific biological function markers, which demonstrated the diversity of TCs subsets in lung tissue. Further results showed TCs had communication with epithelial cells or immune cells subsets by the ligand–receptor interaction, including TIMP metallopeptidase inhibitor 1CD63, fibulin 1integrin subunit beta 1, vimentinCD44, macrophage migration inhibitory factorCD74, and amyloid beta precursor proteinCD74. Ligand–receptor interaction heterogeneity was revealed in lung tissue of healthy or diseases. Enhanced specific signals in ligandreceptor interaction were revealed, including integrin beta 1 and CD44 were appraised in the communication of TCs with epithelial cells, NK cells, NKT cells, CD4+ exhausted T cells, CD4+ memory/effector T cells, CD4+ naïve T cells, CD8+ exhausted T cells, CD8+ memory/effector T cells, and CD8+ naïve T cells. CD63, a marker identified in TCs exosomes was emphasized in our current analysis which is closely related to communication of TCs with other cell types.ConclusionThese results will provide us with new insight into the mechanisms of TCs‐dominated communication and promise therapy of TC exosomes in lung diseases.

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Section: Discussionmentioning

confidence: 99%

Section: F I G U R Ementioning

confidence: 99%

Single‐cell RNA sequencing reveals telocytes subsets of human lung

Dai,

Cai,

Wang

et al. 2024

Clinical and Translational Dis

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“…TCs orchestrated cell‐cell communication was crucial modulators of intercellular signalling through adjacent epithelial, nervous, vascular and immune cells or long‐distance communication by direct contacts or releasing cytokines/EVs for modulation at long remoteness (Figures 1 and 2). 15–17 …”

Section: Structure Of Tc‐mediated Cell Communicationmentioning

confidence: 99%

Roles of telocytes dominated cell–cell communication in fibroproliferative acute respiratory distress syndrome

Zheng,

Cai,

Zhao

et al. 2024

Clinical and Translational Dis

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Telocytes (TCs) are a new type of interstitial cell identified in multiple tissues of mammals, including the human lung, and mediate homocellular or heterocellular cell‐cell communication. Acute respiratory distress syndrome (ARDS) is characterized by acute hypoxemia respiratory failure and combined with direct and indirect lung injury, which is induced by pneumonia, sepsis, burns, etc. Pulmonary fibrosis is a progressive lung disease that occurs due to increased fibrosis of lung tissue in response to chronic injury of the epithelium and gets more and more attention as a well‐recognized sequela of ARDS or mechanical ventilation. However, the existing intervention measures could not prevent the progression of pulmonary fibrosis. Although the protective effect of TCs in acute lung injury had been demonstrated in both cellular and animal models in previous studies by our or other researchers, the roles of TCs mediated cell‐cell communication in fibroproliferative ARDS is unclear. This review is aimed at integrating our understanding of TC‐mediated cell–cell communication in lung diseases with pulmonary fibrosis after ARDS.

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“…On the other hand, in the heart, TCs regulation of the WNT signaling pathway (and concomitantly other pathways) conducts cardiomyocyte differentiation and maturation, helping the integration of young cardiac muscle cells into adult heart architecture [ 72 ]. However, the impairment of maturation of Wnt proteins is followed by the decrease of stem cell activity, subsequently undermining digestive epithelial renewal [ 70 ].…”

Section: Skin Tcsmentioning

confidence: 99%

Dermal Telocytes: A Different Viewpoint of Skin Repairing and Regeneration

Manole

Gherghiceanu

Ceafalan

et al. 2022

Cells

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Fifteen years after their discovery, telocytes (TCs) are yet perceived as a new stromal cell type. Their presence was initially documented peri-digestively, and gradually throughout the interstitia of many (non-)cavitary mammalian, human, and avian organs, including skin. Each time, TCs proved to be involved in diverse spatial relations with elements of interstitial (ultra)structure (blood vessels, nerves, immune cells, etc.). To date, transmission electron microscopy (TEM) remained the single main microscopic technique able to correctly and certainly attest TCs by their well-acknowledged (ultra)structure. In skin, dermal TCs reiterate almost all (ultra)structural features ascribed to TCs in other locations, with apparent direct implications in skin physiology and/or pathology. TCs’ uneven distribution within skin, mainly located in stem cell niches, suggests involvement in either skin homeostasis or dermatological pathologies. On the other hand, different skin diseases involve different patterns of disruption of TCs’ structure and ultrastructure. TCs’ cellular cooperation with other interstitial elements, their immunological profile, and their changes during remission of diseases suggest their role(s) in tissue regeneration/repair processes. Thus, expanding the knowledge on dermal TCs could offer new insights into the natural skin capacity of self-repairing. Moreover, it would become attractive to consider that augmenting dermal TCs’ presence/density could become an attractive therapeutic alternative for treating various skin defects.

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Dynamic Involvement of Telocytes in Modulating Multiple Signaling Pathways in Cardiac Cytoarchitecture

Cited by 10 publications

References 148 publications

Single‐cell RNA sequencing reveals telocytes subsets of human lung

Single‐cell RNA sequencing reveals telocytes subsets of human lung

Roles of telocytes dominated cell–cell communication in fibroproliferative acute respiratory distress syndrome

Dermal Telocytes: A Different Viewpoint of Skin Repairing and Regeneration

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