Wnt Pathway Inhibitors Are Strongly Down-Regulated in Pituitary Tumors

Elston, Marianne S.; Gill, Anthony J.; Conaglen, John V.; Clarkson, Adele; Shaw, Janet M.; Law, Andrew; Cook, Raymond; Little, Nicholas; Clifton‐Bligh, Roderick; Robinson, Bruce G.; McDonald, Kerrie L.

doi:10.1210/en.2007-0542

Cited by 93 publications

(63 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…the sFRP family is comprised of five sFRPs and Wnt inhibitory factor 1 (WiF1). Elston et al (29) used microarray analysis to compare pituitary tumors to healthy pituitary glands, demonstrating that WIF1 mrna expression is markedly underexpressed in all pituitary tumor subtypes. in addition, they found significantly reduced mRNA expression of two other Wnt pathway inhibitors, sFRP2 and sFRP4, and suggested that the Wnt pathways are important in pituitary tumorigenesis.…”

Section: Btg2 (Btg Family Member 2)mentioning

confidence: 99%

Analysis of differential gene expression by bead-based fiber-optic array in growth-hormone-secreting pituitary adenomas

Jiang

Gui

Zhang

2010

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. Growth-hormone-secreting pituitary adenomas (Ghomas) account for approximately 20% of all pituitary neoplasms. however, the pathogenesis of Ghomas remains to be elucidated. to explore the possible pathogenesis of Ghomas, we used bead-based fiber-optic arrays to examine the gene expression in five GHomas and compared them to three healthy pituitaries. Four differentially expressed genes were chosen randomly for validation by quantitative real-time reverse transcription-polymerase chain reaction. We then performed pathway analysis on the identified differentially expressed genes using the Kyoto Encyclopedia of Genes and Genomes. Array analysis showed significant increases in the expression of 353 genes and 206 expressed sequence tags (ESts) and decreases in 565 genes and 29 ESts. Bioinformatic analysis showed that the genes HIGD1B, HOXB2, ANGPT2, HPGD and BTG2 may play an important role in the tumorigenesis and progression of Ghomas. pathway analysis showed that the wingless-type signaling pathway and extracellular-matrix receptor interactions may play a key role in the tumorigenesis and progression of Ghomas. Our data suggested that there are numerous aberrantly expressed genes and pathways involved in the pathogenesis of GHomas. Bead-based fiber-optic arrays combined with pathway analysis of differentially expressed genes appear to be a valid method for investigating the pathogenesis of tumors.

show abstract

Section: Btg2 (Btg Family Member 2)mentioning

confidence: 99%

Analysis of differential gene expression by bead-based fiber-optic array in growth-hormone-secreting pituitary adenomas

Jiang

Gui

Zhang

2010

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

show abstract

“…RNA was extracted from the A172 cell line to assess endogenous PGDS mRNA levels using TRIzol according to the manufacturer's protocol (Invitrogen) and as described previously (16). Low PGDS mRNA expression levels were measured and confirmed using quantitative PCR as described earlier.…”

Section: Survival Analysismentioning

confidence: 99%

Loss of prostaglandin D2 synthase: a key molecular event in the transition of a low-grade astrocytoma to an anaplastic astrocytoma

Payne

Maleki

Messina

et al. 2008

Molecular Cancer Therapeutics

Self Cite

View full text Add to dashboard Cite

Reduction in the mRNA and protein expression of lipocalin-like prostaglandin D 2 (PGD 2 ) synthase (PGDS), the main arachidonic acid metabolite produced in neurons and glial cells of the central nervous system, is a significant biological event involved in the malignant progression of astrocytomas and is predictive of poor survival. In vitro, the addition of the main PGDS metabolite, PGD 2 , to A172 glioblastoma cells devoid of PGDS resulted in antiproliferative activity and cell death. In vitro PGD 2 substitution also enhanced the efficacy of cyclo-oxygenase-2 inhibitors. This finding has exciting implications for early interventional efforts for the grade 2 and 3 astrocytomas. [Mol Cancer Ther 2008;7(10):3420 -8]

show abstract

“…Several studies have used microarraybased, high-throughput gene profiling for identification of candidate genes and pituitary-specific signaling pathways that may be participate in pituitary tumorigenesis, including studies analyzing GH-secreting adenomas. 19,20,36,43 Except for genes linked to adenoma subtype, including GH and GHRH-R, 36,43 the majority of identified genes with potential tumorigenic effect are not unique to GH-secreting adenomas and seem to contribute to the pathogenesis of most adenomas (Table 1).…”

mentioning

confidence: 99%

Growth hormone-secreting adenomas: pathology and cell biology

Lopes¹

2010

FOC

View full text Add to dashboard Cite

The majority of patients with acromegaly harbor a functioning growth hormone (GH) pituitary adenoma. Growth hormone–secreting adenomas correspond to about 20% of all pituitary adenomas. From the histopathological point of view, a variety of adenomas may present with clinical signs and symptoms of GH hypersecretion including pure GH cell adenomas (densely and sparsely granulated GH adenomas), mixed GH and prolactin cell adenomas, and monomorphous adenomas with primitive cells able to secrete GH and prolactin including the acidophilic stem cell adenoma and the mammosomatotroph cell adenoma. In this article, the author reviews the main pathological features of the GH-secreting adenomas and some of the molecular genetics mechanisms involved in their pathogenesis.

show abstract

Wnt Pathway Inhibitors Are Strongly Down-Regulated in Pituitary Tumors

Cited by 93 publications

References 38 publications

Analysis of differential gene expression by bead-based fiber-optic array in growth-hormone-secreting pituitary adenomas

Analysis of differential gene expression by bead-based fiber-optic array in growth-hormone-secreting pituitary adenomas

Loss of prostaglandin D2 synthase: a key molecular event in the transition of a low-grade astrocytoma to an anaplastic astrocytoma

Growth hormone-secreting adenomas: pathology and cell biology

Contact Info

Product

Resources

About