Wnt-4 Expression Is Increased in Fibroblasts after TGF-??1 Stimulation and during Fetal and Postnatal Wound Repair

Abstract

The authors' data suggest that TGF-beta directly increases Wnt-4 expression in fetal and postnatal fibroblasts and that Wnt-4 is increased in both fetal and postnatal repair.

MicroRNA Profiling in Mid- and Late-Gestational Fetal Skin: Implication for Scarless Wound Healing

“…Furthermore, the antifibrotic TGF-β 3 with established roles in scarless healing was identified as a direct target of miR-29 (Li et al 2009), thus possibly forming complex regulatory networks between miRNAs and TGF-β signaling. Additionally, canonical Wnt and MAPK signaling pathways were recently revealed to be implicated in fetal scarless repair with uncharacterized roles (Colwell et al 2006b;Goldberg et al 2008;Carre et al 2010). These findings support the notion that sophisticated regulatory networks comprised of miRNAs and multiple signaling cascades might modulate scarless phenotypic transition and wound healing.…”

SNPs Previously Associated with Dupuytren's Disease Replicated in a North American Cohort

“…29 The Wnt family of proteins regulates cell growth, proliferation and differentiation and has been linked to abnormal proliferation of fibroblasts, and appears necessary for TGF-β-mediated fibrosis seen in fibrotic diseases. 30,31,32 Modulation of Wnt signaling ultimately leads to changes in gene expression that impact cell proliferation and survival.…”

Minimizing Skin Scarring through Biomaterial Design

“…For instance, major developmental signaling molecules such as Wnt (wingless protein) reveal a role for using embryonic signals in adult wound healing. Wnt3a and fibroblast growth factor 9 (FGF9), both present in some quantities in adult tissue, are being developed as vulnerary agents capable of regenerating dermal appendages in adult scars [50,120,121]. …”