WITHDRAWN: Antiurolithiatic activity of Alternanthera tenella Colla in ethylene glycol induced urolithiasis in rats

Adepu, Sahithi; Devkar, Raviraj Anand; Chaudhary, Shilpee; Setty, M. Manjunath

doi:10.1016/j.ajps.2015.11.003

Cited by 2 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The major antioxidant enzymes in mammals are SOD, catalase, and GPX, which are expressed in the testis (Maiorino et al, 2003;Ischi et al, 2005). Earlier study has marked the involvement of ROS in the infertility due to defective spermatozoa function (Aitken et al, 1987;Agarwal et al 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Rubia cardifolia protects the Ethylene glycol-induced nephrotoxicity. Adepu et al (2015) and Lulat et al (2016) studied the antiurolithiatic effect of Alternanthera tenella colla and lithocare against ethylene glycol-induced urolithiasis in rats, respectively. Antioxidant properties of biflavonoid kolaviron, from the seed of Garcinia kola has been reported against ethylene glycol monoethyl ether (EGEE)-induced reproductive toxicity in male rats by reducing the oxidative stress and improving the quality and quantity of spermatozoa (Adedara and Farombi, 2012).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Delayed response of epididymal sperm characteristics and testicular oxidative stress following EGME exposure: Ameliorating potential of Withania somnifera root extract

2018

J App Pharm Sci

View full text Add to dashboard Cite

Swiss strain male mice were administered orally with ethylene glycol monomethyl ether (EGME) for 6 and 10 days and studied the epididymal sperm characteristics and testicular oxidative stress 24 hours after each duration. Withdrawal study on the same parameters was carried out 20 and 45 days after the mice received EGME for 10 consecutive days. Efficacy of Withania somnifera (Ws) root extract was also studied in the mice received EGME for 10 days only, followed by oral administration of WS, from 11 th day to 30 th day. Treatment with Ws root extract was then terminated and studied the effects on 31 st day. EGME treatment for 6 and 10 consecutive days did not cause significant alterations in the percentage of motile, viable, count and abnormal spermatozoa in the epididymis as well as the oxidative stress in the testis. However significant reductions were noted in these sperm indices with a significant increase in abnormal spermatozoa in the epididymis of 20 days EGME-withdrawal group. Oxidative stress in the testis of the mice of the same group was also elevated as evidenced by significant reductions in the activities of antioxidant enzymes (SOD, catalase and GPX) and increase in lipid peroxidation. Forty five days after withdrawal of the treatment, as well as supplementation with Ws for 20 days in 10 days EGME-treated mice resulted in significant reinstatement in these parameters. The study suggested that the toxicity of EGME noticed during early treatment withdrawal period, may be prevented by Ws

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%