Withanolides from Physalis peruviana showing nitric oxide inhibitory effects and affinities with iNOS

Dong, Bangjian; An, Li; Yang, Xueyuan; Zhang, Xuke; Zhang, Jie; Tuerhong, Muhetaer; Jin, Da Qing; Ohizumi, Yasushi; Lee, Dong‐Ho; Xu, Jing; Guo, Yuanqiang

doi:10.1016/j.bioorg.2019.03.051

Cited by 39 publications

(26 citation statements)

References 33 publications

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“…Peruvianolide C ( 29 ) is a novel withanolide purified from the whole plants of P . peruviana , and the absolute configuration of 29 has been confirmed by comparison of experimental and calculated ECD spectra . (20 S ,22 R ,24 S ,25 S ,26 R )‐15α‐Acetoxy‐5,6β:22,26:24,25‐triepoxy‐26‐methoxy‐4βhydroxyergost‐2‐en‐1‐one ( 30 ) and physapubescin I ( 31 ) having an additional 24β,25β‐epoxy group in ring E were purified from P .…”

Section: The Phytochemical Classificationmentioning

confidence: 89%

“…Withaneomexolide B ( 5 ) is a novel withanolide isolated from the aerial parts of P. neomexicana , and its structure was elucidated by the analysis of the spectroscopic data . Recently, peruvianolide D ( 7 ) was obtained from the whole plants of P. peruviana …”

Section: The Phytochemical Classificationmentioning

confidence: 99%

“…angulata . Peruvianolide E ( 47 ) was obtained from P. peruviana , and the NOESY spectra and Chem3D modelling were utilized to deduce the relative configuration . (17 S ,20 R ,22 R )‐5β,6β‐Epoxy‐18,20‐dihydroxy‐1‐oxowitha‐24‐enolide ( 48 ) was a undescribed withanolide, which was isolated from the whole plant of P. angulata (Figure ) …”

Section: The Phytochemical Classificationmentioning

confidence: 99%

“…Peruvianolide A ( 87 ) is a 24,25‐epoxy withanolide, which has been isolated from the whole plants of P . peruviana …”

Section: The Phytochemical Classificationmentioning

confidence: 99%

“…Withahisolide F ( 349 ) was purified from the aerial parts of P. hispida , which was accompanied by an unusual six‐membered ring‐D moiety . Peruvianolide A ( 351 ) was a novel withanolide isolated from P. peruviana …”

Section: Othersmentioning

confidence: 99%

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Withanolides from the genus Physalis: a review on their phytochemical and pharmacological aspects

Huang

et al. 2019

Journal of Pharmacy and Pharmacology

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Objectives Withanolides are a group of modified C28 ergostane‐type steroids with a C‐22, C‐26 δ‐lactone side chain or a C‐23, C‐26 γ‐lactone side chain. They enjoy a limited distribution in the plant kingdom and predominantly occur in several genera of Solanaceae. Of which, the genus Physalis is an important resource for this type of natural molecules. The present review aims to comprehensively illustrate the structural characteristics and classification of withanolides, and particularly focus on the progression on phytochemical and pharmacological aspects of withanolides from Physalis ranging from January 2015 to June 2019. Key findings Approximately 351 natural withanolides with novel and unique structures have so far been identified from genus Physalis, mainly isolated from the species of P. angulata and P. peruviana. Withanolides demonstrated diverse biological activity, such as anticancer, anti‐inflammatory, antimicrobial, immunoregulatory, trypanocidal and leishmanicidal activity. Their observed pharmacological functions supported the uses of Physalis species in traditional or folk medicines. Summary Due to their unique structure skeleton and potent bioactivities, withanolides are regarded to be promising drug candidates, particularly for developing anticancer and anti‐inflammatory agents. Further investigations for discovering novel withanolides of genus Physalis, exploiting their pharmacological values and evaluating their potency as therapeutic agents are significant work.

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Section: The Phytochemical Classificationmentioning

confidence: 89%

Section: The Phytochemical Classificationmentioning

confidence: 99%

Section: The Phytochemical Classificationmentioning

confidence: 99%

“…Peruvianolide A ( 87 ) is a 24,25‐epoxy withanolide, which has been isolated from the whole plants of P . peruviana …”

Section: The Phytochemical Classificationmentioning

confidence: 99%

Section: Othersmentioning

confidence: 99%

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Withanolides from the genus Physalis: a review on their phytochemical and pharmacological aspects

Huang

et al. 2019

Journal of Pharmacy and Pharmacology

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Cytotoxic withanolides from the leaves of Datura stramonium L.

Pan,

Liu,

et al. 2024

Chemistry & Biodiversity

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Six novel withanolides, along with nine known related compounds were isolated from the leaves of Datura stramonium L. The structures and absolute configurations of the new withanolides were elucidated by employing various spectral techniques and comparing them with those previously reported in the literature. In addition, four withanolides demonstrated interesting cytotoxic activity on LN229 cells with IC50<20 μM.

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Composition and biological effects of goldenberry byproducts: an overview

et al. 2020

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Goldenberry is a wild fruit that has been widely used for centuries, mainly in folk medicine. Most studies of goldenberry have focused on the fruit, but new research has studied its byproducts, which were considered to be waste until recently. The main objective of our study was to systematize the published information regarding the composition of goldenberry byproducts (calyces, leaves, seeds, and pomace) and their effects on biological systems. Goldenberry byproducts contain minerals, amino acids, withanolides, flavonoids, and essential fatty acids, thus representing good sources of these compounds. Some of their major biological effects include anti‐inflammatory, antioxidant, antidiabetic, and antiproliferative effects. Information regarding their toxicity is also presented here. To determine the optimal dosage, further safety studies would be recommended to ensure the best health benefits of these compounds. The available evidence has demonstrated the nutritional value of different byproducts of goldenberry, suggesting them to be potential candidates for use in the cosmetic industry, in the preparation of functional foods, and in phytomedicine for the prevention and adjuvant treatment of some diseases. © 2020 Society of Chemical Industry

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Withanolides from Physalis peruviana showing nitric oxide inhibitory effects and affinities with iNOS

Cited by 39 publications

References 33 publications

Withanolides from the genus Physalis: a review on their phytochemical and pharmacological aspects

Withanolides from the genus Physalis: a review on their phytochemical and pharmacological aspects

Cytotoxic withanolides from the leaves of Datura stramonium L.

Composition and biological effects of goldenberry byproducts: an overview

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