Wiskott–Aldrich syndrome with partial response to transfer factor

Abstract

A male infant presented with dermatitis, purpura and susceptibility to bacterial infections. The clinical diagnosis of Wiskott-Aldrich syndrome was confirmed and after full immunological assessment, treatment with transfer factor was commenced. This has resulted in a rise in the platelet count and improvement in the bleeding tendency. This improvement in the haematological aspect of the disease has, however, been accompanied by exacerbations of the cutaneous lesions.

Immune deficiency and multiple viral warts: a possible variant of the Wiskott-Aldrich syndrome

“…Our patient does not have a compatible sibling donor and was considered unsuitable for transplantation because of the severity of his lung disease. An alternative treatment is with transfer factor, a dialysable extract of leukocytes which has been shown to increase the platelet count and improve the bleeding tendency in the Wiskott-Aldrich syndrome (Mackie et a/., 1978). Spitler (1979) treated thirty-two patients with transfer factor and observed clinical benefit with improved survival in 44",,.…”