Studies on T-cell subsets in atopic dermatitis: Human T-cell subpopulations defined by specific monoclonal antibodies

Faure, M; Nicolas, Jean‐François; Thivolet, J; Gaucherand, M; Czernielewski, J.

doi:10.1016/0090-1229(82)90030-7

Cited by 25 publications

(11 citation statements)

References 30 publications

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“…The total number of T lymphocytes was estimated both by the standard E-rosette technique [14] and by OKTII and OKT3 monoclonal antibodies (Ortho Pharmaceutical Corp., Raritan, N.J.) which recog nize the E-rosette forming cells and the whole T-cell, population [15,16], respectively. In addition, OKT4 OKT6 and OK.T8 monoclonal antibodies (Ortho Pharmaceutical Corp., Raritan, N.J.) were used to re cognize T-cell subsets in which helper T cells, com mon thymocytes and cytotoxic-suppressor T cells are thought to be included [15], Indirect immunofluores- cence was used to assess binding of monoclonal an tibodies [15], and fluorescent cells were counted on a Leitz Orthoplan microscope (E. Leitz, Wetzlar, FRG) and compared to the total number of cells.…”

Section: T-cell Subsetsmentioning

confidence: 99%

“…In addition, OKT4 OKT6 and OK.T8 monoclonal antibodies (Ortho Pharmaceutical Corp., Raritan, N.J.) were used to re cognize T-cell subsets in which helper T cells, com mon thymocytes and cytotoxic-suppressor T cells are thought to be included [15], Indirect immunofluores- cence was used to assess binding of monoclonal an tibodies [15], and fluorescent cells were counted on a Leitz Orthoplan microscope (E. Leitz, Wetzlar, FRG) and compared to the total number of cells. Ab solute numbers of T-cell subsets were obtained by white cell and differential counts performed on ED-TA-treated peripheral blood.…”

Section: T-cell Subsetsmentioning

confidence: 99%

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Changes in Superoxide Anion Production in Neutrophils from Multitransfused β-Thalassemia Patients: Correlation with Ferritin Levels and Liver Damage

et al. 1984

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Superoxide anion production in resting and PMA- or zymosan-stimulated neutrophils was evaluated in 21 β-thalassemia patients. The results were correlated with ferritin values, hepatitis B virus serum markers, liver pathology, immunoglobulin levels and T-cell subsets. Superoxide anion generation from resting or PMA-stimulated neutrophils was significantly higher in patients than in controls. On the contrary, zymosan-stimulated neutrophils showed reduced superoxide anion production. Increased superoxide anion production in resting neutrophils showed a significant correlation to the values of ferritin. In addition, patients with biopsy-proven chronic liver disease showed significantly increased ferritin levels and superoxide anion production as compared to the remaining patients. No correlation was observed between superoxide anion production and the presence or the absence of hepatitis B virus serum markers, immunoglobulin levels and T-cell subsets. A possible role of interreactions between iron and oxygen radicals in determining liver damage in β-thalassemia patients is suggested.

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Section: T-cell Subsetsmentioning

confidence: 99%

Section: T-cell Subsetsmentioning

confidence: 99%

Changes in Superoxide Anion Production in Neutrophils from Multitransfused β-Thalassemia Patients: Correlation with Ferritin Levels and Liver Damage

et al. 1984

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“…In fact, a reduced percentage of T cells or of positive T8 lymphocytes was found in patients with atopic dermatitis and in those with E-hypergammaglobulin emia [Romagnani et al, 1978;Canonica et al, 1979;Faure et al, 1982;Leung et al, 1983;Chandra and Baker, 1983], A de pressed lymphoproliférative response to T-cell mitogens was also demonstrated [Grove et al, 1975;Rivlin et al, 1981;Romagnani et al, 1985].…”

Section: Discussionmentioning

confidence: 99%

“…Deficiency in T cells was more pronounced in certain subsets of T lym phocytes. In fact, no significant modifica tion of helper responsiveness has been found, while many data suggest the pres ence of a relative, selective suppressor Tcell deficiency in atopic patients with high serum levels of immunoglobulin E [Canonica et al, 1979;Bruno et al, 1983;Faure et al, 1982;Chandra and Baker, 1983;Kesarwala et al, 1984], Moreover, a signi ficant reduction in NK-cell activity has been shown in patients with atopic derma titis [Lever et al, 1984], Obviously, defects in the host defense system may predispose to greater than normal susceptibility to bacterial, viral and mycotic infections [Rosen et al, 1984], Conflicting results have been reported about the susceptibility of atopic patients to infections. It is well known that patients with severe atopic dermatitis [Jones et al, 1973;Hanifin and Lobitz, 1977;Minor et al, 1974] and atopic children less than 1 year of age frequently suffer from serious and recurrent infections.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Host Defense System in Asthmatic Patients

et al. 1986

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The efficiency of some components of the host defense system has been evaluated in 32 atopic patients with rhinitis, asthma or asthma and rhinitis. No alterations in components of complement (C3 and C4), serum immunoglobulins (IgG, IgA, and IgM) and neutrophil functional parameters were found. As expected, serum IgE values were higher than in controls. A decreased percentage of total circulating T lymphocytes, an increased percentage of la 1-positive cells, but normal values of OKT4- and OKT8-positive T lymphocytes were demonstrated. However, a greater heterogeneity in the distribution of the suppressor-cytotoxic subset was shown in atopic patients.

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“…(e) Patients with atopic dermatitis and those with E-hypergammaglobulinemia have in creased percentages of T4+ and reduced percentages of T8+ lymphocytes [16,17]. (f) The defect of T-cell subsets precedes clinical atopic disease and seems to be of primary pathogenetic importance, as well as of predictive value [18].…”

Section: Impairment O F Ige-specific Regulatory Tcells In Atopic Subjmentioning

confidence: 99%

New Trends on the Pathogenetic Aspects of Allergic Bronchial Asthma

Prete¹,

Maggi²,

Romagnani³

1986

Respiration

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The central role of IgE antibodies in allergic bronchial asthma (ABA) is not disputed any longer. Immunological mechanisms other than IgE-mediated reactions in the pathogenesis of ABA have not yet been definitely demonstrated. There is controversy as to whether IgG STS antibodies, probably IgG4, play a role in the disease process. There is no evidence to support the involvement of immune complexes. Anti-beta-2-adrenergic receptor autoimmune responses cannot be considered as responsible for the development of the disease at the present time. In the last few years a great effort has been made to understand the immunological mechanisms underlying the enhanced and long-standing IgE antibody production in atopic diseases. The results obtained in different laboratories, including our own, are in favor of a high responder status to allergen epitopes in a large proportion of atopies and suggest that a preferential expression of IgE isotype in the antibody responses may occur through different mechanisms. Of great interest is the recent demonstration of IgE-binding factors with IgE-potentiating and suppressive activity and of other related regulatory molecules and receptors. Progress has been recently achieved in the characterization of mediators responsible for the different pathological changes of ABA. A linkage between immediate IgE-mediated reactions, bronchial late-phase reactions (LPR) and chronic inflammation (CI) has been reported. It has been demonstrated that a cascade of mediators and cell interactions induce both LPR and CI. There is evidence of a close relationship between LPR-CI and nonspecific bronchial hyperreactivity. A better knowledge of pathogenetic mechanisms of ABA would open new perspectives in the therapy. A modulation of IgE antibody production can be attempted in different ways. At present a control of mediator release and of airway hyperreactivity can be achieved by several pharmacological interventions and by the avoidance of common and/or occupational allergens or pollutants.

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Studies on T-cell subsets in atopic dermatitis: Human T-cell subpopulations defined by specific monoclonal antibodies

Cited by 25 publications

References 30 publications

Changes in Superoxide Anion Production in Neutrophils from Multitransfused β-Thalassemia Patients: Correlation with Ferritin Levels and Liver Damage

Changes in Superoxide Anion Production in Neutrophils from Multitransfused β-Thalassemia Patients: Correlation with Ferritin Levels and Liver Damage

Evaluation of the Host Defense System in Asthmatic Patients

New Trends on the Pathogenetic Aspects of Allergic Bronchial Asthma

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