Wireless capsule endoscopy

Wang, Amy; Banerjee, Subhas; Barth, Bradley; Bhat, Yasser M.; Chauhan, Shailendra S.; Gottlieb, Klaus; Konda, Vani J.; Maple, John T.; Murad, Faris; Pfau, Patrick R.; Pleskow, Douglas K.; Siddiqui, Uzma D.; Tokar, Jeffrey L.; Rodriguez, Sarah A.

doi:10.1016/j.gie.2013.06.026

Cited by 269 publications

(132 citation statements)

References 110 publications

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“…Some studies have shown that 2 L of PEG may be adequate for small bowel visualization in VCE [26]. However, current guidelines indicate that a full or partial bowel preparation may be used prior to VCE [17]; therefore, we opted to study both a 2 and 4 L PEG bowel preparation. While many trials have compared the efficacy of clear liquids versus purgative small bowel preparations prior to VCE, to our knowledge, our study is the largest prospective study comparing clear liquids to PEG preparations in a diverse patient population with various underlying comorbidities.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies support the use of purgative small bowel preparations, whereas others suggest that a clear liquids regimen may be sufficient. The most recent American Society for Gastrointestinal Endoscopy Report notes that standard practice for bowel preparation prior to VCE includes fasting or consumption of clear liquids for 10-24 h prior to VCE; data on the use of a partial or full bowel preparation prior to VCE are conflicting [17]. While the use of VCE has become more widespread, currently there remains a lack of consensus on guidelines for optimal small bowel preparation prior to VCE.…”

Section: Introductionmentioning

confidence: 99%

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Clear Liquids versus Polyethylene Glycol Preparation for Video Capsule Endoscopy of the Small Bowel: A Randomized Controlled Trial

2018

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Background: An effective bowel cleanse can improve the imaging quality of video capsule endoscopy (VCE). We aimed to further investigate the optimal small bowel cleanse method by comparing the efficacy of 4 L of clear liquids, 2 L of polyethylene glycol (PEG), and 4 L of PEG on the image quality of VCE. Methods: A randomized controlled, non-inferiority trial was performed comparing 4 L of clear liquids (Group A), 2 L of PEG (Group B), and 4 L of PEG (Group C). The primary endpoint was image quality between the groups. The secondary endpoints included patient tolerability and side effects. Results: Eighty-one patients were analyzed in group A, 84 patients were analyzed in group B, and 80 patients were analyzed in group C. Image quality scores revealed 4 L of clear liquids to be non-inferior to 2 L of PEG, and 2 L of PEG to be non-inferior to 4 L of PEG (p < 0.0167). Group A had a lower difficulty of completion rate than Group B and Group C and a lower rate of side effects when compared to Group C (p < 0.0167). Conclusion: Four liters of clear liquids should be considered a routine method for small bowel preparation prior to VCE.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clear Liquids versus Polyethylene Glycol Preparation for Video Capsule Endoscopy of the Small Bowel: A Randomized Controlled Trial

2018

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“…1 Despite sustained technical advancements, 2,3 VCE sequences are still manually reviewed, which is a timeconsuming task that typically lasts 45-90 min and requires the undivided concentration of the reviewer. 4 This process is prone to diagnostic errors as a result of the natural limitation of human capabilities.…”

Section: Introductionmentioning

confidence: 99%

Software for enhanced video capsule endoscopy: challenges for essential progress

Iakovidis

Koulaouzidis

2015

Nat Rev Gastroenterol Hepatol

182

108

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Video capsule endoscopy (VCE) has revolutionized the diagnostic work-up in the field of small bowel diseases. Furthermore, VCE has the potential to become the leading screening technique for the entire gastrointestinal tract. Computational methods that can be implemented in software can enhance the diagnostic yield of VCE both in terms of efficiency and diagnostic accuracy. Since the appearance of the first capsule endoscope in clinical practice in 2001, information technology (IT) research groups have proposed a variety of such methods, including algorithms for detecting haemorrhage and lesions, reducing the reviewing time, localizing the capsule or lesion, assessing intestinal motility, enhancing the video quality and managing the data. Even though research is prolific (as measured by publication activity), the progress made during the past 5 years can only be considered as marginal with respect to clinically significant outcomes. One thing is clear-parallel pathways of medical and IT scientists exist, each publishing in their own area, but where do these research pathways meet? Could the proposed IT plans have any clinical effect and do clinicians really understand the limitations of VCE software? In this Review, we present an in-depth critical analysis that aims to inspire and align the agendas of the two scientific groups.

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“…More recently, Kotwal et al [14] found a similar result as well as an improvement in the diagnostic yield in their analysis of ten studies utilizing purgative preparations. The American Society for Gastrointestinal Endoscopy has not issued a recommendation for or against preparation [23].…”

Section: Discussionmentioning

confidence: 99%

Single-Dose Linaclotide Is Equal in Efficacy to Polyethylene Glycol for Bowel Preparation Prior to Capsule Endoscopy

Stein

Copland

McDaniel

et al. 2019

Dig Dis

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Background: Video capsule endoscopy provides noninvasive visualization of the small bowel, but yield is often limited by debris. At our institution, preparation with polyethylene glycol (PEG) and simethicone is used to improve visualization. Aims: We hypothesized that linaclotide and simethicone would yield equal to better results. Methods: We enrolled 29 subjects for the experimental regimen of linaclotide and simethicone. We maintained standard NPO status, clear liquid period, and simethicone dose. Subjects received 290 μg of linaclotide 1 h prior to capsule. We randomly selected 30 historical PEG controls. Two blinded gastroenterologists graded visualization as ideal/excellent, good, fair, or poor and measured small bowel transit time. Results: Thirteen men and 16 women were enrolled with an average age of 61. There was no significant difference in exam quality between linaclotide and control. Preparation was rated as ideal/excellent or good in 19 of 28 of linaclotide and 18 of 28 PEG subjects when recorder entered the small bowel (p = 0.78, chi-square). Median small bowel transit was 192 min (linaclotide) versus 202 min (PEG), respectively (p = 0.93, t test). Three studies (1 linaclotide and 2 PEG) failed to leave the stomach; 1 linaclotide subject had recorder failure. Diagnostic yield was similar (18/29 for linaclotide and 16/30 for PEG, p = 0.50, chi-square). There were no serious side effects. No differences in age, sex, BMI, or frequency of diabetes, GERD, or gastroparesis were measured between the groups. Conclusions: Single-dose linaclotide 1 h before capsule endoscopy was equally effective when compared to PEG in terms of visualization and transit time. This trial was registered at ClincialTrials.gov, number NCT02465385.

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Wireless capsule endoscopy

Cited by 269 publications

References 110 publications

Clear Liquids versus Polyethylene Glycol Preparation for Video Capsule Endoscopy of the Small Bowel: A Randomized Controlled Trial

Clear Liquids versus Polyethylene Glycol Preparation for Video Capsule Endoscopy of the Small Bowel: A Randomized Controlled Trial

Software for enhanced video capsule endoscopy: challenges for essential progress

Single-Dose Linaclotide Is Equal in Efficacy to Polyethylene Glycol for Bowel Preparation Prior to Capsule Endoscopy

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