Wingless eliminates ommatidia from the edge of the developing eye through activation of apoptosis

Lin, Hua; Rogulja, Ana; Cadigan, Ken M.

doi:10.1242/dev.01104

Cited by 66 publications

(85 citation statements)

References 56 publications

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“…3 Each hexagonal lattice contains 12 IOCs, including six secondary pigment cells at the edges, three tertiary pigment cells and three bristle cells at the vertices. 5,6 The undetermined IOCs are then removed by apoptosis. 7 It has been shown that intercellular communication has an essential role in regulating IOC apoptosis.…”

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confidence: 99%

“…This process is mediated by the secretion of a glycoprotein, Wingless, which promotes its own expression in the periphery of the eye and activates the caspase-dependent apoptosis pathway. 6 The entire cell population of the perimeter ommatidia is eliminated, including the photoreceptor cells, cone cells, primary pigment cells and IOCs. 6 Apoptosis is an important variant of PCD and is executed by caspases.…”

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Tousled-like kinase mediated a new type of cell death pathway in Drosophila

et al. 2015

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Programmed cell death (PCD) has an important role in sculpting organisms during development. However, much remains to be learned about the molecular mechanism of PCD. We found that ectopic expression of tousled-like kinase (tlk) in Drosophila initiated a new type of cell death. Furthermore, the TLK-induced cell death is likely to be independent of the canonical caspase pathway and other known caspase-independent pathways. Genetically, atg2 RNAi could rescue the TLK-induced cell death, and this function of atg2 was likely distinct from its role in autophagy. In the developing retina, loss of tlk resulted in reduced PCD in the interommatidial cells (IOCs). Similarly, an increased number of IOCs was present in the atg2 deletion mutant clones. However, double knockdown of tlk and atg2 by RNAi did not have a synergistic effect. These results suggested that ATG2 may function downstream of TLK. In addition to a role in development, tlk and atg2 RNAi could rescue calcium overload-induced cell death. Together, our results suggest that TLK mediates a new type of cell death pathway that occurs in both development and calcium cytotoxicity.

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Tousled-like kinase mediated a new type of cell death pathway in Drosophila

et al. 2015

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“…During the pupal phase, the most peripheral ring of ommatidia is eliminated by apoptosis (59-61), while the surrounding secondary and tertiary pigment cells survive and contribute to the PR (61). Wg signaling at mid-pupation is required for the death of these 80-100 ommatidia that often lack the full complement of cells (60)(61)(62).…”

Section: Wg Surrounding the Eye Patterns The Peripheral Retinamentioning

confidence: 99%

“…Wg signaling at mid-pupation is required for the death of these 80-100 ommatidia that often lack the full complement of cells (60)(61)(62). This programmed cell death also requires the Snail group transcription factors Worniu (Wor), Escargot (Esg) and Snail (Sna), which are targets of the Wg signaling pathway (62).…”

Section: Wg Surrounding the Eye Patterns The Peripheral Retinamentioning

confidence: 99%

“…This programmed cell death also requires the Snail group transcription factors Worniu (Wor), Escargot (Esg) and Snail (Sna), which are targets of the Wg signaling pathway (62). Interestingly, wg overexpression or loss of the negative regulator of Arm activity Adenomatous polyposis coli 1 in the retinal lattice is sufficient to elicit arm-dependent apoptosis of all photoreceptors at mid-pupation (61,63,64).…”

Section: Wg Surrounding the Eye Patterns The Peripheral Retinamentioning

confidence: 99%

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Wingless Signaling in Drosophila Eye Development

Legent

Treisman

2008

Methods in Molecular Biology

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The Drosophila eye disc gives rise to both the retina and the surrounding head capsule. The secreted morphogen Wingless (Wg) plays an important role in subdividing the disc between these two tissues; wg is expressed in the anterior lateral margins, regions that will give rise to the head capsule, and high levels of Wg signaling promote this fate. Wg is expressed earlier and more strongly in the dorsal than the ventral margin, and also contributes to specifying dorsal identity. In addition, Wg signaling can cause overgrowth of eye disc cells. Finally, at pupal stages, wg expression surrounds the eye and a gradient of Wg establishes several distinct peripheral cell fates. We describe how to generate clones of cells mutant for genes encoding components of the Wg signaling pathway in the eye disc and examine their effects on photoreceptor differentiation by antibody staining.

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Canonical wingless signaling regulates cone cell specification in the Drosophila retina

Cordero¹,

Cagan²

2010

Developmental Dynamics

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Correct tissue patterning during development involves multiple morphogenetic events that include specification of different cell fates, cell proliferation, cell death, and coordinated changes in cell shape, position, and adhesion. Here, we use the Drosophila retina to explore the molecular mechanisms that regulate and integrate these various events. In a previous report, we found that wingless (wg) was required to induce a previously unknown surge of cell death (''early death'') in the pupal retina. Here, we show that wg is also required to induce the more widely studied mid-pupal cell death (''late death'') in a process that involves regulation of DIAP1. Furthermore, our data suggest that wg has a previously unreported role in specifying the glial-like cone cells. This activity requires canonical Wg signaling and is linked with Notch pathway activity. Our work broadens the role of canonical Wg signaling to encompass multiple patterning steps in the emerging Drosophila retina. Developmental Dynamics 239:875-884,

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Wingless eliminates ommatidia from the edge of the developing eye through activation of apoptosis

Abstract: SummaryWingless eliminates ommatidia from the edge of the developing eye through activation of apoptosis

Cited by 66 publications

References 56 publications

Tousled-like kinase mediated a new type of cell death pathway in Drosophila

Tousled-like kinase mediated a new type of cell death pathway in Drosophila

Wingless Signaling in Drosophila Eye Development

Canonical wingless signaling regulates cone cell specification in the Drosophila retina

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