Wilt-inducing antibiotic compounds produced by Cephalosporium gregatum

Kobayashi, Kiroku; Ui, Tadao

doi:10.1016/0048-4059(77)90087-x

Cited by 37 publications

(22 citation statements)

References 6 publications

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“…Aspertetronin A (3) and aspertetronin B (4) were firstly reported in 1969 [12] [13]. Gregatin A (the enantiomer of 3) and gregatins C and D, which were also 5-methoxyfuran-3(2H)-one derivatives, can cause wilting, death of leaves, and vascular browning of adzuki-bean and mung-bean cuttings, and had also an inhibitory action on a wide range of fungi and bacteria in antibiotic tests [15] [16]. Besides, recent research revealed that a class of 5-methoxyfuran-3(2H)-one derivatives including penicilliol A (6) exhibited selective inhibitory activity on eukaryotic Y-family DNA polymerases, a target for antitumor and anti-HIV [11].…”

mentioning

confidence: 99%

Furanone Derivatives from Aspergillus sp. XW‐12, an Endophytic Fungus in Huperzia serrata

Zhan

Jin

Ying

et al. 2011

Helvetica Chimica Acta

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Two new 5-methoxyfuran-3(2H)-one derivatives, huaspenone A (1) and B (2), together with four known ones, i.e., aspertetronin A (3), aspertetronin B (4) , gregatin E (5), and penicilliol A (6), were isolated from the cultures of an endophytic fungus Aspergillus sp. XW-12, derived from the stems of Huperzia serrata. The structures of the new isolates were established by detailed interpretation of the 1D-and 2D-NMR and HR-ESI-MS data.

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mentioning

confidence: 99%

Furanone Derivatives from Aspergillus sp. XW‐12, an Endophytic Fungus in Huperzia serrata

Zhan

Jin

Ying

et al. 2011

Helvetica Chimica Acta

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“…It is also worth noting that the foliar severity measurement was not strongly correlated to either stem measurement. If there were a toxin produced by P. gregata causing leaf necrosis and chlorosis, as has been previously suggested (Gray and Chamberlain, 1975;Kobayashi and Ui, 1977), stem measurements would not account for the damage caused by the toxin. Therefore, for the most accurate characterization of soybean resistance or susceptibility, both foliar severity and recovery of P. gregata measurements need to be recorded.…”

Section: Determination Of Appropriate Brown Stem Rot Screening Methodsmentioning

confidence: 99%

Identifying New Sources of Resistance to Brown Stem Rot in Soybean

et al. 2016

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Brown stem rot (BSR), caused by the fungus Phialophora gregata f. sp. sojae (Allington & D.W. Chamberlain) W. Gams (syn. Cadophora gregata), causes yield losses up to 38%. Three dominant BSR‐resistant genes have been identified: Rbs1, Rbs2, and Rbs3. Additional BSR resistance loci will complement breeding efforts by expanding the soybean [Glycine max (L.) Merr.] genetic base. The objective of this research was to determine if PI 594637, PI 594638B, PI 594650A, and PI 594858B contained novel BSR resistance genes. The accessions were crossed to three genotypes with known BSR resistance genes and populations were developed for allelism studies. A minimum of 60 F2:3 families tracing to individual F2 plants in each population were used, and six seeds from each F2:3 family were tested. Resistant and susceptible controls and parents were also included. The BSR symptoms were assessed under growth chamber conditions 5 wk after inoculation by measuring foliar and stem severities and recovery of P. gregata from stem sections. Allelism tests of F2:3 plants from crosses of PI 594638B, PI 594858B, and PI 594650A with the resistant sources fit a 15:1 ratio, indicating that the resistant gene possessed by each of the PIs was nonallelic to Rbs1, Rbs2, and Rbs3. The three PIs contain at least one novel BSR resistance gene and have the potential to serve as donors to elite germplasm, increasing stability of host resistance to P. gregata. Allelism tests of PI 594637 segregated in a 3:1 ratio and no significant difference was found between PI 594637 and the susceptible controls, indicating that PI 594637 is susceptible to BSR.

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“…These results led to two hypotheses concerning the pathogenic role of gregatins: gregatins play a very small role in pathogenicity and gregatins show phytotoxic effects at extremely low concentrations during in the natural disease. Gregatins also have antimicrobial activity (Kobayashi and Ui 1977) and may contribute more to saprophytic survival of P. gregata rather than to phytotoxicity. Further examination will be essential to reveal whether gregatins are involved in pathogenicity and how they function in this context.…”

Section: Condition Amentioning

confidence: 99%

“…1) (Kobayashi andUi 1975, 1980). Gregatins A, C, and D cause vascular browning and wilting in adzuki beans, which resemble symptoms of disease (Kobayashi and Ui 1977). Spontaneous and induced gregatin-deficient mutants have reduced pathogenicity (Kobayashi 1984), suggesting that gregatins may play a role in pathogenicity.…”

Section: Introductionmentioning

confidence: 99%