Isolation of pathogenicity- and gregatin-deficient mutants of Phialophora gregata f. sp. adzukicola through Agrobacterium tumefaciens-mediated transformation

Miniolins A–C, novel isomeric furanones induced by epigenetic manipulation of Penicillium minioluteum

“…Members of the furanone structural class of natural oxygenated heterocycles have been reported from fungi of the genera Cephalosporium (for example, gregatins and graminin A), Aspergillus (aspertetronins, huaspenones A and B), [18][19][20] Penicillium (penicilliol) and Paraconiothyrium (graminin B), 31 and they show a wide range of bioactivities, such as phytotoxic 32 and DNA polymerase inhibitory effects. 33 To the best of our knowledge, miniolins A-C (1-3) represent the rst instances of aspertetronin dimers in nature.…”

Recent Applications of Phosphane-based Palladium Catalysts in Suzuki-Miyaura Reactions Involved in Total Syntheses of Natural Products

“…umbraculifer (Fabaceae) seed extract[62a] and from Amorpha nana (Fabaceae)[62b] and was shown to exhibit antimicrobial [62b] and antidiabetic properties;[62c] cladoacetals A (27) and B (28), two benzofused dioxabicyclo[4.2.1]nonene derivatives isolated from fermentation cultures of an unidentified fungicolous isolate; [63] oteromycin (29), a novel antagonist of endothelin receptor first isolated from fungus strains MF 5810 and MF 5811; [64] isobongkreic acid [(E)-30], a fatty triacid which was obtained from the fermentation of Pseudomonas cocovenants; [65] bongkreic acid [(Z)-30], an anti-apoptotic agent produced by Burkholderia gladioli pathovar cocovenants (formerly Pseudomonas cocovenants) (Burkhoderiaceae); [66] vialinin A (terrestrin A) (31), a terphenyl compound isolated from the dry fruiting bodies of the mushroom Telephora vialis, which was shown to possess potent inhibitory activity of TNF-a production from RBL-2113 cells; [67] sauristolactam (32), an alkaloid first isolated from the extracts of the aquatic weed Saururus cernuus, [68a] which was found to be active against a variety of tumor cells;[68b] carbazomadurin A (33) a polysubstituted carbazole alkaloid isolated from the microorganism Actinomadura madurae 2808-SV1; [69] (+)-carbazomadirin B (40), a neuronal cell-protecting carbazole alkaloid isolated from A. madurae 2808-SV1; [69,76] the potent antimitotic agent leiodermatolide (34), a macrolide isolated from the deep-water marine sponge Leiodermatium sp. ; [70](R)trichostatin (35a), an antibacterial metabolite isolated from strains of the bacterial species Streptomyces hygroscopicus; [71a] (R)-trichostatic acid (35b), a compound isolated from S. sioyaensis, which was reported to induce differentiation of leukemia cells;[71b] prekinamycin (36), a metabolite produced by S. murayamensis mutant MC2; [72] 3-methoxy-2,5-diphenylcyclohexa-2,5-dien-1,4-dione (37), an ortho-quinone isolated from common coelomycetous soil fungi Phoma sp., which is an inhibitor of parasite cyclic GMP-dependent protein kinase;[73] ecteinascidin 743 (38), an extremely potent antitumor agent isolated from the Caribbean tunicate Ectinascidia turbinata;[74] (S,5Z,8E,10E)-12-hydroxyheptadeca-5,8,10-trienoic acid (39), a co-product of the pathway leading to thromboxane A2 from PGH2, a metabolite of cyclooxygenase; [75] (+)gregatin B (41), a phytotoxic metabolite produced by the Deuteromycete fungus Phialophora gregata adzukicola, a causal agent of brown stem rot in adzuki beans; [77] rodgersinol (42), a 2-arylpropanol isolated from the aerial parts of Rodgersia...…”

Characterization of nonpathogenic Cadophora gregata, a potential biological control agent, concomitantly isolated from soil infested with Cadophora gregata f. sp. adzukicola, the cause of adzuki bean brown stem rot

“…Consequently, the pathogen can cause susceptible plants to wilt and reduce adzuki bean yields. Although phytotoxic gregatins produced by CGA previously were thought to be associated with these symptoms (Kobayashi and Ui, 1977), Tanaka et al (2007) found that the toxins were unlikely to be essential for pathogenicity.…”