Willingness to Receive COVID-19 Vaccination Among People Living With HIV and AIDS in China: Nationwide Cross-sectional Online Survey

Huang, Xiaojie; Yu, Maohe; Fu, Gengfeng; Lan, Guanghua; Li, Linghua; Yang, Jianzhou; Qiao, Ying; Zhao, Jin; Qian, Han-Zhu; Zhang, Xiangjun; Liu, Xinchao; Jin, Xingming; Chen, Guohong; Jiang, Hui; Tang, Weiming; Wang, Zixin; Xu, Junjie

doi:10.2196/31125

Cited by 35 publications

(34 citation statements)

References 37 publications

(32 reference statements)

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“…We fitted a single logistic regression model to obtain adjusted odds ratios (AOR), which involved one of the independent variable of interest and all background characteristics with P values less than .05 in univariate analysis. The same approach to obtain AOR was commonly used in published studies [ 19 , 20 , 22 , 27 , 28 ]. There was no missing value for the participants who completed the survey.…”

Section: Methodsmentioning

confidence: 99%

“…At the individual level, the Theory of Planned Behavior (TPB) postulates that in order to perform a behavior, one would evaluate the pros and cons of the behavior (positive and negative attitudes), consider whether their significant others would support such behavior (perceived subjective norm), and appraise how much control one has over the behavior (perceived behavioral control) [ 19 ]. The TPB was commonly used to explain a health behavior and guide the behavioral intervention [ 20 , 21 ]; it has been used to explain willingness to receive COVID-19 vaccination among Chinese people [ 22 ]. Studies conducted among the Hong Kong general population identified the perceived pros and cons that were associated with the willingness to receive COVID-19 vaccination.…”

Section: Introductionmentioning

confidence: 99%

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Multilevel Determinants of COVID-19 Vaccine Uptake Among South Asian Ethnic Minorities in Hong Kong: Cross-sectional Web-Based Survey

Singh¹,

Lai²,

Wang³

et al. 2021

JMIR Public Health Surveill

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Background The COVID-19 pandemic continues to have a disproportionate effect on ethnic minorities. Across countries, greater vaccine hesitancy has been observed among ethnic minorities. After excluding foreign domestic helpers, South Asians make up the largest proportion of ethnic minorities in Hong Kong. It is necessary to plan for COVID-19 vaccination promotional strategies that cater to the unique needs of South Asians in Hong Kong. Objective This study investigated the prevalence of COVID-19 vaccine uptake among a sample of South Asians in Hong Kong. We examined the effects of sociodemographic data and factors at individual level (perceptions), interpersonal level (information exposure on social media), and sociostructural level (cultural) based on the socioecological model. Methods A cross-sectional web-based survey was conducted on May 1-31, 2021. Participants were South Asian people aged 18 years or older living in Hong Kong; able to comprehend English, Hindi, Nepali, or Urdu; and having access to a smartphone. Three community-based organizations providing services to South Asians in Hong Kong facilitated the data collection. The staff of the community-based organizations posted the study information in WhatsApp groups involving South Asian clients and invited them to participate in a web-based survey. Logistic regression models were fit for data analysis. Results Among 245 participants, 81 (33.1%) had taken at least one dose of the COVID-19 vaccine (one dose, 62/245, 25.2%; and both doses, 19/245, 7.9%). After adjusting for significant background characteristics, cultural and religious reasons for COVID-19 vaccine hesitancy were associated with lower COVID-19 vaccine uptake (adjusted odds ratio [AOR] 0.83, 95% CI 0.71-0.97; P =.02). At the individual level, having more positive attitudes toward COVID-19 vaccination (AOR 1.31, 95% CI 1.10-1.55; P =.002), perceived support from significant others (AOR 1.29, 95% CI 1.03-1.60; P =.03), and perceived higher behavioral control to receive COVID-19 vaccination (AOR 2.63, 95% CI 1.65-4.19; P <.001) were associated with higher COVID-19 vaccine uptake, while a negative association was found between negative attitudes and the dependent variable (AOR 0.73, 95% CI 0.62-0.85; P <.001). Knowing more peers who had taken the COVID-19 vaccine was also associated with higher uptake (AOR 1.39, 95% CI 1.11-1.74; P =.01). At the interpersonal level, higher exposure to information about deaths and other serious conditions caused by COVID-19 vaccination was associated with lower uptake (AOR 0.54, 95% CI 0.33-0.86; P =.01). Conclusions In this study, one-third (81/245) of our participants received at least one dose of the COVID-19 vaccine. Cultural or religious rea...

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Multilevel Determinants of COVID-19 Vaccine Uptake Among South Asian Ethnic Minorities in Hong Kong: Cross-sectional Web-Based Survey

Singh¹,

Lai²,

Wang³

et al. 2021

JMIR Public Health Surveill

Self Cite

View full text Add to dashboard Cite

show abstract

“…No study has compared PLWH and HIV-negative individuals when it comes to the immunogenicity and safety of the inactivated SARS-CoV-2 vaccines. Such evidence is important to address COVID-19 vaccine hesitancy among PLWH and to implement booster doses for this group [28]. Previous findings on mRNA/adenovirus vector vaccines might not be applicable to PLWH receiving inactivated SARS-CoV-2 vaccines [20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Comparing Immune Responses to Inactivated Vaccines against SARS-CoV-2 between People Living with HIV and HIV-Negative Individuals: A Cross-Sectional Study in China

Huang

Yan

et al. 2022

Viruses

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This study compared the immunogenicity of inactivated SARS-CoV-2 vaccines between people living with HIV (PLWH) and HIV-negative individuals. We recruited 120 PLWH and 53 HIV-negative individuals aged 18–59 years who had received an inactivated SARS-CoV-2 vaccine in two Chinese cities between April and June 2021. Blood samples were tested for immunogenicity of the inactivated SARS-CoV-2 vaccines. The prevalence and severity of adverse events associated with SARS-CoV-2 vaccines were similar between PLWH and HIV-negative individuals. The seropositivity of neutralizing activity against authentic SARS-CoV-2, of the total amount of antibody (total antibody) and of S-IgG were 71.3%, 81.9%, and 92.6%, respectively, among fully vaccinated PLWH. Among all participants, PLWH had lower neutralizing activity, total antibody, S-IgG, and T-cell-specific immune response levels, compared to HIV-negative individuals, after controlling for types of vaccine, time interval between first and second dose, time after receiving the second dose, and sociodemographic factors. PLWH with a longer interval since HIV diagnosis, who received their second dose 15–28 days prior to study commencement, and who had an interval of ≥21 days between first and second dose had higher neutralizing activity levels. The immunogenicity of the inactivated SARS-CoV-2 vaccines was lower among PLWH as compared to HIV-negative individuals. Vaccination guideline specific for PLWH should be developed.

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“…Alternative or substitute ways to access healthcare for HIV during the COVID-19 epidemic might be considered. For example, Jiang et al found that more MSM self-tested for HIV (52.1% vs. 41.6%) but fewer MSM used facility-based HIV testing (42.9% vs. 54.1%) during COVID-19 measures compared to before COVID-19 measures (68). Furthermore, as compared to PLWH in other countries and the general population in most parts of the world, PLWH in China reported a relatively low willingness to receive the COVID-19 vaccination (69).…”

Section: Hiv/aids During the Covid-19 Epidemicmentioning

confidence: 99%

“…For example, Jiang et al found that more MSM self-tested for HIV (52.1% vs. 41.6%) but fewer MSM used facility-based HIV testing (42.9% vs. 54.1%) during COVID-19 measures compared to before COVID-19 measures ( 68 ). Furthermore, as compared to PLWH in other countries and the general population in most parts of the world, PLWH in China reported a relatively low willingness to receive the COVID-19 vaccination ( 69 ). The internet and social media as well as interpersonal communications may be major sources of influence on PLWH’s perceptions and willingness to receive COVID-19 vaccination, which have important implications for immunization programs targeting PLWH.…”

Section: Hiv/aids During the Covid-19 Epidemicmentioning

confidence: 99%

Research Progress in the Epidemiology of HIV/AIDS in China

He¹

2021

China CDC Weekly

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After thirty-two years since the first domestic outbreak of human immunodeficiency virus (HIV)/ acquired immune deficiency syndrome (AIDS) among injection drug users (IDUs) and almost two decades of comprehensive response efforts by the Chinese government, HIV/AIDS remains a major public health problem. The increasing burden of HIV/AIDS and comorbidities, the emergence of new HIV subtypes and/or circulating recombinant forms and drug mutations, the changing transmission networks, and the urgency of immediate antiretroviral therapy initiation upon an HIV diagnosis are increasingly challenging and altogether likely to have significant impact on the HIV epidemic in China. Upon the call for the global AIDS response to end AIDS by 2030, China needs to develop an innovative and pragmatic roadmap to address these challenges. This review is intended to provide a succinct overview of what China has done in efforts to achieve the global goal of ending AIDS by 2030 and the recently proposed "95-95-95-95" target (95% combination prevention, 95% detection, 95% treatment, 95% viral suppression), and to summarize the most recent progresses in the epidemiological research of HIV/AIDS in China with the aim of providing insights on the next generation of HIV control and prevention approaches and to shed light on upgrading the national strategy to end AIDS in this country.

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Willingness to Receive COVID-19 Vaccination Among People Living With HIV and AIDS in China: Nationwide Cross-sectional Online Survey

Cited by 35 publications

References 37 publications

Multilevel Determinants of COVID-19 Vaccine Uptake Among South Asian Ethnic Minorities in Hong Kong: Cross-sectional Web-Based Survey

Multilevel Determinants of COVID-19 Vaccine Uptake Among South Asian Ethnic Minorities in Hong Kong: Cross-sectional Web-Based Survey

Comparing Immune Responses to Inactivated Vaccines against SARS-CoV-2 between People Living with HIV and HIV-Negative Individuals: A Cross-Sectional Study in China

Research Progress in the Epidemiology of HIV/AIDS in China

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