“…The median number of PEP prescriptions recorded per day was 8 (4-15) during the 1,117 days before NPIs (23 January, 2020), compared with 4 (2-7) during the 76 days of NPIs (23 January, 2020 to 7 April, 2020, the NPIs period), and 14 (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) during the 268 days post-NPIs (8 April, 2020 to 31 December, 2020, post-NPIs period). Poisson segmented regression analysis showed that the number of PEP prescriptions decreased by 71¢ 5% in the first week of the NPIs period (20-26 January, 2020) (incidence rate ratio [IRR] 0¢285; 95% confidence interval [CI] 0¢192-0¢423; Table 2 and Figure 2A; compared with counterfactual), then 71¢2% (0¢288, 0¢197-0¢ 423) and 70¢8% (0¢292, 0¢201-0¢424) in the second (27 January-2 February, 2020) and third week (3-9 February, 2020), respectively; the number of prescriptions showed an increasing trend of 2¢4% per week in the post-NPIs period (1¢024,1¢012-1¢037), and by the end of 2020 (28-31 December, 2020) the number of prescriptions still had not reached expected level (0¢523,0¢394-0¢696).…”