Wild Carrot Oil Extract is Selectively Cytotoxic to Human Acute Myeloid Leukemia Cells

Tawil, Mirna; Bekdash, Amira; Mroueh, Mohammad; Daher, Costantine F.; Abi-Habib, Ralph J.

doi:10.7314/apjcp.2015.16.2.761

Cited by 30 publications

(27 citation statements)

References 25 publications

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“…This phenomena is similar to earlier observations by us and others [13,38,43]. It is, thus, repeatedly evident that while free Dox is internalized by passive diffusion through the cell membrane, the uptake of Dox@PMNPs is rather directed by one type of endocytic trafficking mechanisms, specifically micropinocytosis [44,45]. Taking into consideration the distinctive mechanistic cellular uptake between the free drug and drug-loaded NPs (fast diffusion vs vesicular trafficking), our results strongly suggest that Dox@PMNPs can be a promising potential platform for selective drug delivery to human leukemic patients.…”

Section: Resultssupporting

confidence: 76%

Magnetic Nanocarriers Enhance Drug Delivery Selectively to Human Leukemic Cells

El‐Boubbou¹,

Ali²,

Bahhari³

et al. 2017

J Nanomed Nanotechnol

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Section: Resultssupporting

confidence: 76%

Magnetic Nanocarriers Enhance Drug Delivery Selectively to Human Leukemic Cells

El‐Boubbou¹,

Ali²,

Bahhari³

et al. 2017

J Nanomed Nanotechnol

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“…Inhibition of the MAPK pathway decreased sensitivity of AML cells to DCOE, indicating that cytotoxicity may be dependent on its activity. The authors concluded that, DCOE induced selective apoptosis in AML cells, possibly through a MAPK-dependent mechanism [101].The chemopreventive effects of oil extract from Daucus carota umbels was investigated on 7,12-dimethyl benz(a)anthracene (DMBA)-induced skin papilloma in mice. The extract was administered to animals via gavage (0.02 ml of 100% oil), intraperitoneal (0.3 ml of 2% oil), and topical (0.2 ml of 5, 50, and 100% oil) routes for 20 weeks.…”

Section: Pharmacological Effects: Cytotoxic Effectsmentioning

confidence: 99%

Nutritional and therapeutic importance of Daucus carota- A review

Al-Snafi¹

2017

IOSRPHR

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Abstract:-Phytochemical analysis showed that the root of Daucus carota contained alkaloids, carbohydrates, chlorogenic acid, flavonoids, phenols, essential oil, terpenoid and coumarin. The nutritional analysis of carrot juice showed that the juice contained: protein 1.067 ± 0.058%, crude fat 0.367 ± 0.089%, crude fibre 1.167 ± 0.153%, carbohydrates 6.100 ± 0.346%, many vitamins and minerals. The pharmacological studies revealed that the plant possessed cytotoxic, antioxidant, antidiabetic, antimicrobial, smooth muscle relaxant, hypotensive effect and decrease intraocular pressure, gastro-protective, nephro-protective, hepato-protective, cardioprotective antidepressant memory enhancement, anti-inflammatory, reproductive, wound healing and hear induction and many other effects. The current review highlights the chemical constituents, nutritional and pharmacological effects of Daucus carota.

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“…Previous studies in our laboratory have shown that DC crude oil extract and its fractions demonstrated anti-inflammatory [15], antioxidant [15,16] and anticancerous [15,16,17,18,19,20] activities. However, there are no studies conducted to assess its effect on cancer cell motility and metastasis.…”

Section: Discussionmentioning

confidence: 99%

“…Also, it has been reported to possess antilithic, diuretic [10,11], antibacterial and antifungal activities [12,13,14]. Recent studies conducted in our laboratories showed that D. carota (DC) oil extract exhibited anti-inflammatory, antiulcer [15], antioxidant [16] and anticancer activities [16,17,18]. The DC oil was further fractionated using chromatography, and the various fractions were tested for 2 important factors in cancer malignancy, proliferation and apoptosis [19,20].…”

Section: Introductionmentioning

confidence: 99%

<b><i>Daucus carota</i></b> Pentane/Diethyl Ether Fraction Inhibits Motility and Reduces Invasion of Cancer Cells

Zgheib

Daher²,

Mroueh³

et al. 2014

Chemotherapy

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Daucus carota (DC) is a herb used in folklore medicine in Lebanon to treat numerous diseases including cancer. Recent studies in our laboratory on DC oil and its fractions revealed potent anticancer activities in vitro and in vivo. The present study aims to investigate the effect of the most potent DC fraction, pentane/diethyl ether (50:50), on lung, skin, breast and glioblastoma cancer cell motility and invasion. Upon treatment, a pronounced decrease in cancer cell motility was observed in the 4 cell lines. The treatment also led to a decrease in cancer cell invasion and an increased cell adhesion. Additionally, the DC fraction caused a decrease in the activation of the ρ-GTPases Rac and CDC42, a finding that may partially explain the treatment-induced decrease in cell motility. The current study demonstrates a crucial effect of the DC pentane/diethyl ether fraction on cancer cell motility and metastasis, making it a potential candidate for cancer therapy specifically targeting cancer motility and metastasis.

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Wild Carrot Oil Extract is Selectively Cytotoxic to Human Acute Myeloid Leukemia Cells

Cited by 30 publications

References 25 publications

Magnetic Nanocarriers Enhance Drug Delivery Selectively to Human Leukemic Cells

Magnetic Nanocarriers Enhance Drug Delivery Selectively to Human Leukemic Cells

Nutritional and therapeutic importance of Daucus carota- A review

<b><i>Daucus carota</i></b> Pentane/Diethyl Ether Fraction Inhibits Motility and Reduces Invasion of Cancer Cells

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