Wie Carl-Bertil Laurell und Sten Eriksson vor 50 Jahren den Alpha-1-Antitrypsin-Mangel entdeckten und was danach kam - ein etwas eigenwilliger persönlicher Rückblick

Konietzko, N

doi:10.1055/s-0033-1344745

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…In 1963, Laurell and Eriksson of Sweden proposed the hypothesis of protease-antiprotease imbalance, a classic mechanism of COPD, by discovering that α1-antitrypsin (α1-AT) deficiency is closely related to emphysema in youth [22]. It is suggested that the pathogenesis of COPD and emphysema is the result of an imbalance between the enzymes that degrade the extracellular matrix in the lung and the proteins that oppose this proteolytic activity [23].…”

Section: Regulation Of Protease/antiprotease Imbalancementioning

confidence: 99%

Progress in the Protective Mechanism of Salidroside in Chronic Obstructive Pulmonary Disease

Ruan¹,

Hu²

2023

IJCEMR

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Chronic obstructive pulmonary disease (COPD) is a heterogeneous lung disease that is persistent, repeatedly deteriorating airway obstruction due to respiratory abnormalities (bubuchitis, bronchiolitis) and/or alveolar abnormalities (emphysema). Salidroside, a widespread natural phenolic secondary metabolite found in Rhododiola, has several pharmacological effects. Relevant studies have shown that salidroside has protective effects in anti-diabetes, anti-cancer, anti-aging, heart and nerve protection, etc. Due to the limitations of clinical drug use in COPD, salidroside has multiple functions and low side effects, and its protective effect and mechanism of action on COPD have attracted increasing attention. By collecting relevant papers published in recent years, reviewed in the literature against oxidative stress, regulation of protease/anti-protease imbalance, anti-inflammatory, anti-bronchiolar and interstitial fibrosis, anti-telomere shortening, expounds the protective effect and mechanism of its effect in COPD, and provide reference for its clinical application. The clinical and experimental data are not sufficient, and the role and mechanism of salidroside need to be further studied.

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Section: Regulation Of Protease/antiprotease Imbalancementioning

confidence: 99%