Widespread Occurrence and Distribution of Bisphenol A Diglycidyl Ether (BADGE) and its Derivatives in Human Urine from the United States and China

Wang, Lei; Wu, Yinghong; Zhang, Wei

doi:10.1021/es304050f

Cited by 47 publications

(46 citation statements)

References 32 publications

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“…According to the human exposure studies available on BPA-A, equivalent values to those of BPA were found in urine for BPS and BPF, at average levels of about 10 -9 -10 -10 M, (Zhou et al, 2014). BPB and BADGE were detected infrequently and their levels were around 10 -9 M (Cobellis et al, 2009;Cunha and Fernandes, 2010;Wang et al, 2012Wang et al, , 2015Asimakopoulos et al, 2014). The significant BPA-A-induced suppression of testosterone found here occurred for exposure at lower concentrations (generally 10 -6 -10 -8 M) than that observed for BPA.…”

Section: Inhibin Bmentioning

confidence: 99%

Parallel assessment of the effects of bisphenol A and several of its analogs on the adult human testis

et al. 2017

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WHAT IS KNOWN ALREADY:The few epidemiologic studies performed suggest that bisphenols have potential endocrine disruptive properties, but they did not identify clear and direct patterns of endocrine disruption. STUDY DESIGN, SIZE, DURATION:Adult human testis explants in culture were exposed to BPA and the analogs bisphenol F (BPF), bisphenol S (BPS), bisphenol E (BPE), bisphenol B (BPB), and bisphenol A diglycidyl ether (BADGE) at 10 -9 to 10 -5 M for 24 h or 48h.PARTICIPANTS/MATERIALS, SETTING, METHODS: Human adult testes were obtained from prostate cancer patients who had no hormone therapy, or from multiorgan donors. After ex vivo exposure to the investigated bisphenols, the measured outcomes were related to histopathology (gross morphology and germ cell viability determined by anti-caspase 3 immunohistochemistry), and the levels of testosterone, insulin-like fator 3 and inhibin B were measured using immunoassays. The levels of mRNA encoding key enzymes of bisphenol biotransformation were investigated by quantitative PCR: UGT2B15 UDP (glucuronosyltransferase two family, polypeptide B15), GUSB (glucuronidase beta), SULT1A1 and 3 (sulfotransferase family 1 A member 1 and 3) and STS (steroid sulfatase). MAIN RESULTS AND THE ROLE OF CHANCE: A significant dose-dependent inhibition wasfound between testosterone levels measured in the culture medium and concentrations of BPA The active concentrations of BPA and BPA-A used in the study were higher than those found in human biological fluids. WIDER IMPLICATIONS OF THE FINDINGS:Under our experimental conditions, direct exposure to BPA or BPA-A can result in endocrine disturbance in the adult human testis.

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Section: Inhibin Bmentioning

confidence: 99%

Parallel assessment of the effects of bisphenol A and several of its analogs on the adult human testis

et al. 2017

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“…It is clearly established by empirical data that FCCs can migrate from food contact materials and articles into food, indicating a high probability that a large majority of the human population is exposed to some or many of these chemicals [3]. Indeed, for some FCCs there is evidence for human exposure from biomonitoring [4][5][6][7][8][9][10][11], although some FCCs may have multiple uses and also non-food contact exposure pathways.…”

Section: Introductionmentioning

confidence: 99%

Impacts of food contact chemicals on human health: a consensus statement

et al. 2020

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Food packaging is of high societal value because it conserves and protects food, makes food transportable and conveys information to consumers. It is also relevant for marketing, which is of economic significance. Other types of food contact articles, such as storage containers, processing equipment and filling lines, are also important for food production and food supply. Food contact articles are made up of one or multiple different food contact materials and consist of food contact chemicals. However, food contact chemicals transfer from all types of food contact materials and articles into food and, consequently, are taken up by humans. Here we highlight topics of concern based on scientific findings showing that food contact materials and articles are a relevant exposure pathway for known hazardous substances as well as for a plethora of toxicologically uncharacterized chemicals, both intentionally and non-intentionally added. We describe areas of certainty, like the fact that chemicals migrate from food contact articles into food, and uncertainty, for example unidentified chemicals migrating into food. Current safety assessment of food contact chemicals is ineffective at protecting human health. In addition, society is striving for waste reduction with a focus on food packaging. As a result, solutions are being developed toward reuse, recycling or alternative (non-plastic) materials. However, the critical aspect of chemical safety is often ignored. Developing solutions for improving the safety of food contact chemicals and for tackling the circular economy must include current scientific knowledge. This cannot be done in isolation but must include all relevant experts and stakeholders. Therefore, we provide an overview of areas of concern and related activities that will improve the safety of food contact articles and support a circular economy. Our aim is to initiate a broader discussion involving scientists with relevant expertise but not currently working on food contact materials, and decision makers and influencers addressing single-use food packaging due to environmental concerns. Ultimately, we aim to support science-based decision making in the interest of improving public health. Notably, reducing exposure to hazardous food contact chemicals contributes to the prevention of associated chronic diseases in the human population.

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“…Especially, it mimics estrogen. Moreover, BPA can arouse many additional health problems, including weight gain, early-onset of puberty, infertility, behavioral changes, cardiovascular effects and diabetes (Morgan et al, 2011;Johnson et al, 2012;Wang et al, 2012).…”

Section: Health Effects Of Bpamentioning

confidence: 99%