Widespread Environmental Presence of Multidrug-Resistant Salmonella in an Equine Veterinary Hospital That Received Local and International Horses

Soza-Ossandón, Paula; Rivera, Dácil; Tardone, Rodolfo; Riquelme-Neira, Roberto; García, Patricia; Hamilton‐West, Christopher; Adell, Aiko D.; González-Rocha, Gerardo; Switt, Andrea I. Moreno

doi:10.3389/fvets.2020.00346

Cited by 14 publications

(24 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Seventeen (17/27, 63%) studies were from either the small animal or companion animal clinics/hospitals ( 3 , 9 , 17 , 20 , 27 – 33 , 37 , 41 – 44 , 48 ). followed by both bovine ( 38 , 42 , 49 , 50 ) (4/27, 15%) and equine medicine ( 19 , 46 , 47 ). Three (3/27, 11%) studies were a combination of small animals, large animals, and poultry ( 35 , 36 , 40 ).…”

Section: Resultsmentioning

confidence: 99%

“…The antimicrobial resistance profile of the different organisms was provided in eighteen (17/27, 63%) studies ( 3 , 9 , 17 , 20 , 28 , 31 , 33 – 37 , 39 , 40 , 42 , 43 , 46 , 47 ), while nine (9/27, 33%) studies did not report on the antimicrobial resistance patterns ( 19 , 27 , 29 , 30 , 32 , 38 , 41 , 44 , 48 ). Thirteen studies (13/27, 48%) further characterized the microorganisms using pulsed-field gel electrophoresis (PFGE) and polymerase chain reaction (PCR) assays ( 3 , 19 , 20 , 28 , 31 , 33 – 35 , 37 , 40 , 45 – 47 ).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Hospital-acquired and zoonotic bacteria from a veterinary hospital and their associated antimicrobial-susceptibility profiles: A systematic review

et al. 2023

View full text Add to dashboard Cite

BackgroundHospital-acquired infections (HAIs) are associated with increased mortality, morbidity, and an economic burden due to costs associated with extended hospital stays. Furthermore, most pathogens associated with HAIs in veterinary medicine are zoonotic. This study used published data to identify organisms associated with HAIs and zoonosis in veterinary medicine. Furthermore, the study also investigated the antimicrobial-susceptibility profile of these bacterial organisms.MethodsA systematic literature review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Search terms and five electronic databases were used to identify studies published over 20 years (2000–2020). The risk of bias was assessed using the “Strengthening the Reporting of Observational Studies in Epidemiology-Vet” (STROBE-Vet) checklist.ResultsOut of the identified 628 papers, 27 met the inclusion criteria for this study. Most studies (63%, 17/27) included were either from small animal or companion animal clinics/hospitals, while 5% (4/27) were from large animal clinics/hospitals inclusive of bovine and equine hospitals. Hospital-acquired bacteria were reported from environmental surfaces (33%, 9/27), animal clinical cases (29.6%, 8/27), and fomites such as cell phones, clippers, stethoscopes, and computers (14.8%, 4/27). Staphylococcus spp. was the most (63%; 17/27) reported organism, followed by Escherichia coli (19%; 5/27), Enterococcus spp. (15%, 4/27), Salmonella spp. (15%; 4/27), Acinetobacter baumannii (15%, 4/27), Clostridioides difficile (4%, 1/27), and Pseudomonas aeruginosa (4%; 1/27). Multidrug-resistant (MDR) organisms were reported in 71% (12/17) of studies linked to Methicillin-resistant Staphylococcus aureus (MRSA), Methicillin-resistant Staphylococcus pseudintermedius (MRSP), Enterococcus spp., Salmonella Typhimurium, A. baumannii, and E. coli. The mecA gene was identified in both MRSA and MRSP, the blaCMY-2 gene in E. coli and Salmonella spp., and the vanA gene in E. faecium isolate. Six studies reported organisms from animals with similar clonal lineage to those reported in human isolates.ConclusionOrganisms associated with hospital-acquired infections and zoonosis have been reported from clinical cases, environmental surfaces, and items used during patient treatment and care. Staphylococcus species is the most reported organism in cases of HAIs and some isolates shared similar clonal lineage to those reported in humans. Some organisms associated with HAIs exhibit a high level of resistance and contain genes associated with antibiotic resistance.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Hospital-acquired and zoonotic bacteria from a veterinary hospital and their associated antimicrobial-susceptibility profiles: A systematic review

et al. 2023

View full text Add to dashboard Cite

show abstract

“…stalls, surgery room and waterers), with 41% of isolates being MDR (Soza‐Ossandón et al . 2020), which highlights the importance of good hospital biosecurity to prevent disease in horses and hospital personnel. There are limited reports of outbreaks of Salmonella spp.…”

Section: Bacteria Of Concernmentioning

confidence: 99%

Improving clinical outcomes via responsible antimicrobial use in horses

Isgren

2021

Equine Veterinary Education

View full text Add to dashboard Cite

The growing problem of antimicrobial resistance affects veterinarians on a daily basis. Antimicrobial stewardship and responsible prescribing are essential for a future with effective antimicrobials, as it is unlikely that new antimicrobials will become available for use in horses in the near future. Extended-spectrum b-lactamase (ESBL) producing Enterobacteriaceae, methicillin-resistant Staphylococcus aureus (MRSA) and Salmonella spp. are pathogens of significant concern but there are also other opportunistic pathogens such as Pseudomonas spp., a-haemolytic Streptococcus spp., Enterococcus spp. and Acinetobacter spp. which, due to their high intrinsic resistance, have limited treatment options in adult horses. It is essential that highest priority critically important antimicrobials such as ceftiofur, enrofloxacin, rifampicin and polymyxin B are used prudently in horses and ideally based on culture and antimicrobial susceptibility testing (AST). For example, the use of polymyxin B at a low anti-endotoxic dose rather than at a higher antimicrobial dose in horses for the treatment of systemic inflammatory response syndrome is a potential driver for resistance to colistin (polymyxin E), an antimicrobial used as a last resort in the treatment of multidrug resistant (MDR) Enterobacteriaceae infections in humans. Serum procalcitonin levels are used in humans to distinguish noninfectious inflammatory conditions from inflammation caused by bacteria and other infectious agents and are also used to guide cessation of antimicrobial treatment. Although no such studies have been performed in horses, this or other markers may prove to be helpful in guiding antimicrobial treatment decisions in the future. Optimising sampling techniques and good communication with the microbiology laboratory are essential for generating the accurate culture and AST results that underpin appropriate antimicrobial use. Additionally, there is clearly a need for national and international harmonisation of laboratory methods in order to improve the reliability and consistency of results reported by different laboratories.

show abstract

“…Fourth of the categories were classified as closed systems where animals have restricted movement, limited contact with other animal species and are feed by humans. The closed system category is composed of food production animals from eight industrial dairy farms (160 samples) [ 20 ] and 10 swine farms (182 samples), domestic animals from an equine veterinary hospital (545 samples) [ 21 ] and wild animals from three wildlife rehabilitation centers (405 samples) [ 19 ]. Samples were also obtained from animals living free-range outdoors, which were potentially being fed with unsafe remains of food, such as human waste [ 22 ].…”

Section: Methodsmentioning

confidence: 99%

“…The microbiology isolation method used in this study has been previously described [ 21 ]. Samples were cultured in buffered peptone water (Beckton-Dickinson, Franklin Lakes, NJ, USA) at 37 °C for 24 h. One-hundred microliters were transferred into Rappaport Vassiliadis (RV) media (Beckton-Dickinson) supplemented with novobiocin (20 mg/mL), and 1 mL was transferred into tetrathionate (TT) (Beckton-Dickinson) supplemented with iodine.…”

Section: Methodsmentioning

confidence: 99%

Screening the Presence of Non-Typhoidal Salmonella in Different Animal Systems and the Assessment of Antimicrobial Resistance

Rivera

Allel

Dueñas

et al. 2021

Animals

Self Cite

View full text Add to dashboard Cite

Salmonella is a major bacterial foodborne pathogen that causes the majority of worldwide food-related outbreaks and hospitalizations. Salmonellosis outbreaks can be caused by multidrug-resistant (MDR) strains, emphasizing the importance of maintaining public health and safer food production. Nevertheless, the drivers of MDR Salmonella serovars have remained poorly understood. In this study, we compare the resistance profiles of Salmonella strains isolated from 4047 samples from domestic and wild animals in Chile. A total of 106 Salmonella strains (2.61%) are isolated, and their serogroups are characterized and tested for susceptibility to 16 different antimicrobials. The association between antimicrobial resistance (AMR) and a subset of independent variables is evaluated using multivariate logistic models. Our results show that 47 antimicrobial-resistant strains were found (44.3% of the total strains). Of the 47, 28 correspond to single-drug resistance (SDR = 26.4%) and 19 are MDR (17.9%). S. Enteritidis is highly persistent in animal production systems; however, we report that serogroup D strains are 18 times less likely to be resistant to at least one antimicrobial agent than the most common serogroup (serogroup B). The antimicrobials presenting the greatest contributions to AMR are ampicillin, streptomycin and tetracycline. Additionally, equines and industrial swine are more likely to acquire Salmonella strains with AMR. This study reports antimicrobial-susceptible and resistant Salmonella in Chile by expanding the extant literature on the potential variables affecting antimicrobial-resistant Salmonella.

show abstract

Widespread Environmental Presence of Multidrug-Resistant Salmonella in an Equine Veterinary Hospital That Received Local and International Horses

Cited by 14 publications

References 31 publications

Hospital-acquired and zoonotic bacteria from a veterinary hospital and their associated antimicrobial-susceptibility profiles: A systematic review

Hospital-acquired and zoonotic bacteria from a veterinary hospital and their associated antimicrobial-susceptibility profiles: A systematic review

Improving clinical outcomes via responsible antimicrobial use in horses

Screening the Presence of Non-Typhoidal Salmonella in Different Animal Systems and the Assessment of Antimicrobial Resistance

Contact Info

Product

Resources

About