Widespread cutaneous necrosis associated with the lupus anticoagulant

Abstract

Summary We describe a patient who presented with large painful areas of cutaneous necrosis and in whom the presence of the lupus anticoagulant was demonstrated. This abnormality is associated with a tendency to spontaneous thrombosis but widespread cutaneous necrosis has not been reported previously. The response to systemic steroids was dramatic whereas heparin proved ineffective.

Scabies presenting as a necrotizing vasculitis in the presence of lupus anticoagulant

“…Vasculitis is occasionally reported in histopathological studies. [8][9][10][11][12] The typical histopathology of patients with cutaneous lesions associated with circulating lupus anticoagulant shows non-inflammatory thrombosis of dermal and subcutaneous vessels, with no significant vasculitis. 7 The antiphospholipid antibodies (i.e.…”

Thrombophilia: the dermatological clinical spectrum

“…Histopathology analyses reveal damage to the microvasculature with fibrin thrombi in the post-capillary venules and small veins and diffuse but non-specific necrosis of the dermis and subcutaneous tissues [36,[52][53][54][55][56][57].…”

Manifestações cutâneas das trombofilias

“…34 A histopatologia revela dano da microvasculatura com trombos de fibrina nas vênulas pós-capilares e pequenas veias, necrose difusa de derme e subcutâneo. 34 Achados microscópicos idênticos têm sido observados na doença renal terminal com calcifilaxia, 48 na embolia por colesterol, 49 criofibrinogenemia, 50 necrose cutânea pela SAAF 51,52 ou mesmo no pioderma gangrenoso. 53 Após o início da varfarina, tanto os níveis como a atividade da PC caem abruptamente, comparados aos níveis de outros fatores da coagulação vitamina Kdependentes, como os fatores IX e X, e a protrombina, levando a oclusões trombóticas e à necrose.…”