Single‐carrier transmission with frequency domain equalisation (SC‐FDE) is one of the candidates for the next generation indoor wireless personal area networks operating at millimetre waves in the frequency band around 60 GHz. In this study, a 64.8 GHz SC‐FDE wireless mobile radio system is presented and its back‐to‐back performance verified. The transceiver employs fractionally spaced minimum mean‐square‐error frequency domain equalisation, that is, compliant with the IEEE 802.15.3c millimetre‐wave standard. Results of experiments, undertaken at 64.8 GHz in a number of indoor environments, to characterise the effectiveness of the SC‐FDE technique to mitigate the effects of multipath propagation are presented for line‐of‐sight and non‐line‐of‐sight scenarios. Bit‐error‐rate performance for 16‐quadrature amplitude modulation 100 Mb/s transmission is given as a function of signal‐to‐noise ratio for a combination of omnidirectional and directional antennas at both terminals and compared with that obtained in additive white Gaussian noise channel.