Wide range of chromosome abnormalities in the embryos of young egg donors

Prognostic factors in oocyte donation: an analysis through egg-sharing recipient pairs showing a discordant outcome

“…They concluded that aggressive ovarian stimulation protocols yield large oocyte cohorts that are prone to form embryos with a higher rate of chromosome abnormalities. A more recent study by Munn e et al (30) found similar aneuploidy rates of 57% in 124 egg donor cycles. Another interesting finding was the great variability between different egg donors that showed a normal distribution, with almost one third of the donors having fewer than 30% of normal embryos.…”

Is sperm dna damage associated with IVF embryo quality? A systematic review

“…There is a growing body of literature suggesting that the morphology-based embryo scoring systems (as reported in the analyzed studies) are imperfect. Indeed, one of the main drawbacks of these scoring systems is that they are poor predictors of the genetic integrity and chromosomal composition of the embryo [36]. Emerging techniques for evaluating the embryos might provide more accurate information on overall the quality and chromosomal integrity of the cultured embryo (e.g.…”

Preimplantation genetic screening: does it help or hinder IVF treatment and what is the role of the embryo?

“…It is well known that the rate of chromosome abnormalities is higher in patients with AMA and RPL. Also, PGS has been used in women with previous trisomic conceptions [36] who have partners with male factor infertility [37][38][39], and in egg donors [40]. Today, the use of PGS for healthy patients with no indications for the purpose of improving IVF outcomes is on the rise.…”