Why it is necessary to translate curcumin into clinical practice for the prevention and treatment of metabolic syndrome?

Sahebkar, Amirhossein

doi:10.1002/biof.1130

Cited by 31 publications

(37 citation statements)

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“…Curcumin has documented anti‐inflammatory [Esmaily et al, ; Panahi et al, ], antioxidant [Panahi et al, ; Sahebkar et al, , ; Panahi et al, ] and immunomodulatory [Ganjali et al, ; Panahi et al, , , d; Derosa et al, ; Ghandadi and Sahebkar, ; Karimian et al, ; Mohammadi et al, ; Sahebkar et al, ] activities, and has been found to exert a number of pharmacological therapeutic benefits in a variety of human diseases. Diseases in which curcumin has been shown to produce positive health benefits include osteoarthritis [Panahi et al, ; Sahebkar and Henrotin, ], cancer [Abbas Momtazi and Sahebkar, ; Mirzaei et al, ; Sahebkar, ; Teymouri et al, ], dyslipidemia [Mohammadi et al, ; Panahi et al, ; Sahebkar, , ; Ganjali et al, ], the metabolic syndrome [Sahebkar, ], hyperuricemia [Panahi et al, ], non‐alcoholic fatty liver disease [Rahmani et al, ; Zabihi et al, ], anxiety and depression [Esmaily et al, ; Panahi et al, ], ischemia/reperfusion injury [Sahebkar, ], diabetes [Nabavi et al, ], pulmonary disorders [Panahi et al, , ; Lelli et al, ], and dermatological disturbances [Panahi et al, ]. This wide range of pharmacological effects has been proposed to be due to the numerous molecular targets of curcumin (Table ).…”

Section: Curcumin: Source Structure and Therapeutic Effectsmentioning

confidence: 99%

Curcumin: A Naturally Occurring Modulator of Adipokines in Diabetes

Hajavi

Momtazi

Johnston

et al. 2017

J of Cellular Biochemistry

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Curcumin, the bioactive component of turmeric, has been used for the treatment of several diseases including diabetes and its complications. Curcumin has been shown to exert pleiotropic effects by modulating different signaling molecules, including transcription factors, chemokines, cytokines, and adipokines. Disturbed regulation of adipokines, which include adiponectin, leptin, resistin, and visfatin, are implicated in the development of insulin resistance and Type 2 diabetes. Here, we review the findings of in vitro, in vivo, and clinical studies on the modulating effects that curcumin treatment exerts on adipokines. Additionally, we examine the potential beneficial effects of the activity of curcumin in the prevention and treatment of diabetes and its comorbidities. J. Cell. Biochem. 118: 4170-4182, 2017. © 2017 Wiley Periodicals, Inc.

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Section: Curcumin: Source Structure and Therapeutic Effectsmentioning

confidence: 99%

Curcumin: A Naturally Occurring Modulator of Adipokines in Diabetes

Hajavi

Momtazi

Johnston

et al. 2017

J of Cellular Biochemistry

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“…There is a strong pile of evidence indicating diverse biological activities and health benefits of plant phytochemicals, in particular phenolics and flavonoids (Hodgson and Croft, ; Sahebkar, , , Hu et al ., ; Xiao et al ., ; Huang et al ., ; Ikemura et al ., ; Mohammadi et al ., ; Panahi et al ., , b; Sahebkar, , ; Shin et al ., ). Large‐scale prospective cohorts have suggested an inverse association between consumption of fruits and vegetables rich in flavonoids and CVD mortality (Liu et al ., ; Mink et al ., ).…”

Section: Introductionmentioning

confidence: 99%

Clinical Evaluation of Blood Pressure Lowering, Endothelial Function Improving, Hypolipidemic and Anti‐Inflammatory Effects of Pomegranate Juice in Hypertensive Subjects

Asgary

Sahebkar

Afshani

et al. 2013

Phytotherapy Research

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Pomegranate (Punica granatum L.) juice (PJ) contains different types of antioxidants and bioactive polyphenols and has been reported to promote cardiovascular health through several mechanisms. The present study aimed to examine the effects of 2-week intake of fresh PJ on blood pressure, flow-mediated dilatation (FMD), serum lipid profile and concentrations of inflammatory and endothelial function biomarkers. Twenty-one hypertensive patients (aged 30-67 years) were recruited into the trial and assigned to receive either PJ (150 ml/day in a single occasion between lunch and dinner; n = 11) or the same amount of water (n = 10) for a period of 2 weeks. Systolic (SBP) and diastolic (DBP) pressures together with FMD and serum concentrations of lipid profile parameters, apolipoproteins A and B, intracellular adhesion molecule-1 (ICAM-1), vascular endothelial adhesion molecule 1 (VCAM-1), E-selectin, high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) were measured at baseline and at the end of trial. PJ consumption was associated with significant reductions in SBP (p = 0.002) and DBP (p = 0.038) but not FMD (p > 0.05). Serum levels of VCAM-1 (p = 0.008) were significantly reduced by PJ while those of E-selectin were elevated (p = 0.039). However, no significant effect was observed from PJ on serum levels of ICAM-1, hs-CRP, lipid profile parameters, apolipoproteins and IL-6 in any of the study groups (p > 0.05). Consumption of PJ for 2 weeks has effective hypotensive effects, and may improve endothelial function by decreasing serum concentrations of VCAM-1. These findings suggest PJ as a beneficial cardioprotective supplement for hypertensive subjects.

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“…Curcuminoids constitute about 5% of turmeric composition and comprise curcumin (65–80%; also referred to as curcumin I), demethoxycurcumin (15–25%; curcumin II), and bisdemethoxycurcumin (5–15%; curcumin III). Curcuminoids possess several medicinal properties, and their efficacy has been confirmed against a wide array of diseases (Ganjali et al ., ; Gupta et al ., , ; Iranshahi et al ., ; Panahi et al ., ; Sahebkar, , , , , ; Shehzad et al ., , ) 9. Most of the pharmacological properties of curcuminoids are due to their potent antiinflammatory (Panahi et al ., ; Shehzad et al ., ) and antioxidant (Ak and Gulcin, ; Panahi et al ., ; Sahebkar et al ., ) effects.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Efficacy of Adjunctive Therapy with Bioavailability‐Boosted Curcuminoids in Major Depressive Disorder

Panahi

Badeli

Karami

et al. 2014

Phytotherapy Research

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Current medications have limited efficacy in controlling the symptoms of major depressive disorder (MDD), and are associated with several adverse events on long-term use. Curcuminoids are extremely safe and multifunctional phytopharmaceuticals that have been shown to alleviate depressive symptoms in a variety of experimental models. The present study aimed to investigate the efficacy of curcuminoids as an add-on to standard antidepressants in patients with MDD. One hundred and eleven subjects were assigned to standard antidepressive therapy plus curcuminoids-piperine combination (1000-10 mg/day; n=61) or standard antidepressive therapy alone (n=50) for a period of 6 weeks. Efficacy measures were changes in the psychological status on the basis of the Hospital Anxiety and Depression Scale (HADS) and Beck Depression Inventory II (BDI-II). The BDI-II and HADS total and subscale scores were reduced by the end of trial in both study groups. There were significantly greater reductions in total HADS score and subscales of anxiety and depression in the curcuminoids versus control group (p<0.001). Likewise, reductions in BDI-II total score and scores of somatic and cognitive subscales were found to be greater in the curcuminoids compared with control group (p<0.001). Co-administration of curcuminoids with piperine may be used as a safe and effective add-on to standard antidepressants in patients with MDD.

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Why it is necessary to translate curcumin into clinical practice for the prevention and treatment of metabolic syndrome?

Cited by 31 publications

References 0 publications

Curcumin: A Naturally Occurring Modulator of Adipokines in Diabetes

Curcumin: A Naturally Occurring Modulator of Adipokines in Diabetes

Clinical Evaluation of Blood Pressure Lowering, Endothelial Function Improving, Hypolipidemic and Anti‐Inflammatory Effects of Pomegranate Juice in Hypertensive Subjects

Investigation of the Efficacy of Adjunctive Therapy with Bioavailability‐Boosted Curcuminoids in Major Depressive Disorder

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