Curcumin: A Naturally Occurring Modulator of Adipokines in Diabetes

Abstract

Curcumin, the bioactive component of turmeric, has been used for the treatment of several diseases including diabetes and its complications. Curcumin has been shown to exert pleiotropic effects by modulating different signaling molecules, including transcription factors, chemokines, cytokines, and adipokines. Disturbed regulation of adipokines, which include adiponectin, leptin, resistin, and visfatin, are implicated in the development of insulin resistance and Type 2 diabetes. Here, we review the findings of in vitro, in vivo, and clinical studies on the modulating effects that curcumin treatment exerts on adipokines. Additionally, we examine the potential beneficial effects of the activity of curcumin in the prevention and treatment of diabetes and its comorbidities. J. Cell. Biochem. 118: 4170-4182, 2017. © 2017 Wiley Periodicals, Inc.

Highly Dispersible and Bioavailable Curcumin but not Native Curcumin Induces Brown‐Like Adipocyte Formation in Mice

“…Curcumin is a yellow pigment extracted from the rhizomes of Curcuma longa L. (turmeric) and has various biological functions, including anti‐obesity and antidiabetic properties . Some experimental animal and clinical trials have indicated that curcumin has a suppressive effect on the accumulation of body fat .…”

“…[10] Curcumin is a yellow pigment extracted from the rhizomes of Curcuma longa L. (turmeric) and has various biological functions, including anti-obesity and antidiabetic properties. [11,12] Some experimental animal and clinical trials have indicated that curcumin has a suppressive effect on the accumulation of body fat. [13][14][15] However, there is little evidence to indicate that curcumin induces the formation of brown-like adipocytes and the molecular mechanisms are unknown.…”

“…Relative protein levels are expressed as fold-changes relative to the control (= 1) after normalization using the β-actin protein. Data are presented as mean ± SEM (n =[10][11][12][13][14][15][16][17][18][19]. Mean values without a common letter were significantly different (p < 0.05).…”

The role of curcumin in liver diseases

“…So, curcumin has anti-diabetic effects that could be considered as valuable targets for diabetes mellitus [79].…”

Protective effects of curcumin against aflatoxicosis: A comprehensive review

“…Curcumin is the polyphenolic compound that has been traditionally used as a flavoring and coloring agent in most cuisines along with some medical applications to treat various human ailments (Goel, Kunnumakkara, & Aggarwal, 2008). Recently, multiple biological as well as pharmacological activities have been documented for curcumin, including antimicrobial (Jordan & Drew, 1996;Kim, Choi, & Lee, 2003;Mahady, Pendland, Yun, & Lu, 2001;Negi, Jayaprakasha, Jagan Mohan Rao, & Sakariah, 1999;Reddy, Vatsala, Keshamouni, Padmanaban, & Rangarajan, 2005), anti-inflammatory (Ganjali et al, 2014;Mohammadi et al, 2013;Panahi, Alishiri, Parvin, & Sahebkar, 2016;Panahi, Ghanei, Bashiri, Hajihashemi, & Sahebkar, 2015;Panahi, Rahimnia et al, 2014;Panahi, Saadat, Beiraghdar, & Sahebkar, 2014;Panahi, Sahebkar, Parvin, & Saadat, 2012;Sahebkar et al, 2013), antioxidant Esmaily et al, 2015;Panahi, Sahebkar, Amiri et al, 2012;Sahebkar et al, 2013;Sharma, 1976), antidiabetic (Ganjali et al, 2014;Hajavi et al, 2017;Na et al, 2013) and anticancer (Iranshahi et al, 2010;Kuttan, Bhanumathy, Nirmala, & George, 1985;Mahady et al, 2001;Valiahdi, Iranshahi, & Sahebkar, 2013) characteristics. Of note, curcumin is able to treat the toxicity caused by AFB1 (Poapolathep, Imsilp, Machii, Kumagai, & Poapolathep, 2015b).…”