Why Is Sex/Gender-Specific Medicine Needed?

Kim, Nayoung; Schiebinger, Londa

doi:10.1007/978-981-19-0120-1_1

Cited by 4 publications

(4 citation statements)

References 38 publications

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“…Notably, sex hormones, including estrogen and testosterone, play intricate roles in modulating cardiovascular and neuroendocrine system functions. 25 Consequently, the observed discrepancies regarding the influence of HP eradication on ischemic stroke incidence could stem from sex-specific dynamics. Recent data have underscored a decline in coronary heart disease incidence, predominantly among young men and elderly women, post-HP eradication.…”

Section: Introductionmentioning

confidence: 99%

Risk of Ischemic Stroke in Relation to Helicobacter pylori Infection and Eradication Status: A Large-Scale Prospective Observational Cohort Study

Jeon,

Kim,

Kim

et al. 2024

Gut and Liver

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Background/Aims: A few studies have suggested the association between Helicobacter pylori (HP) infection and ischemic stroke. However, the impact of HP eradication on stroke risk has not been well evaluated. This study aimed to assess the influence of HP eradication on the incidence of ischemic stroke, considering the potential effect of sex.Methods: This prospective observational cohort study was conducted at Seoul National University Bundang Hospital, from May 2003 to February 2023, and involved gastroscopy-based HP testing. Propensity score (PS) matching was employed to ensure balanced groups by matching patients in the HP eradicated group (n=2,803) in a 3:1 ratio with patients in the HP non-eradicated group (n=960). Cox proportional hazard regression analysis was used to evaluate the risk of ischemic stroke.Results: Among 6,664 patients, multivariate analysis after PS matching indicated that HP eradication did not significantly alter the risk of ischemic stroke (hazard ratio, 0.531; 95% confidence interval, 0.221 to 1.270; p=0.157). Sex-specific subgroup analyses, both univariate and multivariate, did not yield statistically significant differences. However, Kaplan-Meier analysis revealed a potential trend: the females in the HP eradicated group exhibited a lower incidence of ischemic stroke than those in the HP non-eradicated group, although this did not reach statistical significance (p=0.057). Conclusions:This finding suggests that HP eradication might not impact the risk of ischemic stroke. However, there was a trend showing that females potentially had a lower risk of ischemic stroke following HP eradication, though further investigation is required to establish definitive evidence.

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Section: Introductionmentioning

confidence: 99%

Risk of Ischemic Stroke in Relation to Helicobacter pylori Infection and Eradication Status: A Large-Scale Prospective Observational Cohort Study

Jeon,

Kim,

Kim

et al. 2024

Gut and Liver

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“…There has been growing interest in sex differences in medical conditions both in Korea and around the world [1,2]. Additionally, Korea has established its first institute focusing on sex differences in medicine, mirroring a global trend towards increased awareness of these differences.…”

Section: Introductionmentioning

confidence: 99%

Sex differences in metabolic dysfunction-associated steatotic liver disease: a narrative review

Joo,

Kim

2024

Ewha Med J

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Understanding the effects of sex and sex differences on liver health and disease is crucial for individualized healthcare and informed decision-making for patients with liver disease. The impact of sex on liver disease varies according to its etiology. Women have a lower prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) than men. However, postmenopausal women face a higher risk of advanced liver fibrosis due to hormonal influences. Sex differences affect the pathogenesis of MASLD, which involves a complex process involving several factors such as hormones, obesity, and the gut microbiome. Furthermore, sex-related differences in the development of MASLDrelated hepatocellular carcinoma have been observed. The sex-specific characteristics of MASLD necessitate an individualized management approach based on scientific evidence. However, research in this area has been lacking. This article reviews the current understanding of sex differences in MASLD.

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“…The "Sex and Gender Research in Medical Science" classes held in 2017 and 2019 at the Graduate School of Translational Medicine at Seoul National University College of Medicine received positive feedback from medical students. Later, Sex/Gender-Specific Medicine in Clinical Areas was published [3] with 33 experts in each clinical area. In this paper, I aim to review the concept and necessity of SGM and the challenges and implications it presents to healthcare, practitioners, researchers, and students within the sex/gender-specific framework.…”

Section: Introductionmentioning

confidence: 99%