Why Gilgamesh failed: the mechanistic basis of the limits to human lifespan

Milholland, Brandon; Vijg, Jan

doi:10.1038/s43587-022-00291-z

Cited by 10 publications

(7 citation statements)

References 83 publications

(87 reference statements)

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“…We note that one of the key factors has been the decrease in infant mortality. That is why our population's life expectancy may stagnate for many scientists, among other reasons (seeDong et al, 2016;Milholland & Vijg, 2022). Therefore, we here show the reasons SENS has for its optimism.…”

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confidence: 50%

“…Our point of view is also justified by the idea, increasingly accepted in the scientific community, that there is a limit to maximum human lifespan. For a recent study, seeMilholland & Vijg, 2022. 10 Hauskeller (2014) also shares this opinion that goes to the core of the SENS agenda: "the aim is not the preservation of life as such, but rather the preservation or restoration of youthful life".…”

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confidence: 97%

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The machine-like repair of aging. Disentangling the key assumptions of the SENS agenda

García-Barranquero

Bertolaso

2022

THEORIA

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The possibility of curing aging is currently generating hopes and concerns among entrepreneurs, experts, and the general public. This article aims to clarify some of the key assumptions of the Strategies for Engineered Negligible Senescence agenda, one of the most prominent paradigms for rejuvenation. To do this, we present the three fundamental claims of this research program: (1) aging can be repaired; (2) rejuvenation is possible through the reversal of all molecular damage; (3) and the human organism is a sophisticated machine. Secondly, we argue that this agenda fits with a machine conception of the organism (described by Daniel Nicholson); we show that, if aging is understood from this philosophical approach, there is an internal confusion in the research program between what is repair and what is rejuvenation. Finally, we state that this theoretical viewpoint connects with scientific criticism and reinforces the idea that there are limits to the aspirations to live indefinitely young.

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confidence: 50%

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confidence: 97%

The machine-like repair of aging. Disentangling the key assumptions of the SENS agenda

García-Barranquero

Bertolaso

2022

THEORIA

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“…Set in modern-day Iraq, it tells the story of Gilgamesh, who undertook a perilous journey to search for an antidote to death. 2 An example of eternal youth in Indian history is Markandeya, son of the sage Mrikanda. The sage had chosen a boon in which Lord Shiva offered him a virtuous and pious son, with the rider that the son would die at a young age.…”

Section: Yayati's Eldest Son; Mahabharatamentioning

confidence: 99%

Elegant Aging Through Endocrine Optimization

Sanjay Kalra,

Saurabh Arora,

Nitin Kapoor

2023

IJCP

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“…It remains unclear how organisms evolve their lifespans [4][5][6] . For instance, humans can live over 100 years, but mice can only live < 5 years 4 although they share more than 80% of orthologous proteincoding genes 7 .…”

Section: Introductionmentioning

confidence: 99%

Noncoding RNAs evolutionarily extend animal lifespan

Wang

2023

Preprint

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The mechanisms underlying lifespan evolution in organisms have long been mysterious. However, recent studies have demonstrated that organisms evolutionarily gain noncoding RNAs (ncRNAs) that carry endogenous profound functions in higher organisms1,2, including lifespan3. This study unveils ncRNAs as crucial drivers driving animal lifespan evolution. Species in the animal kingdom evolutionarily increase their ncRNA length in their genomes, coinciding with trimming mitochondrial genome length. This leads to lower energy consumption and ultimately lifespan extension. Notably, during lifespan extension, species exhibit a gradual acquisition of long-life ncRNA motifs while concurrently losing short-life motifs. These longevity-associated ncRNA motifs, such as GGTGCG, are particularly active in key tissues, including the endometrium, ovary, testis, and cerebral cortex. The activation of ncRNAs in the ovary and endometrium offers insights into why women generally exhibit longer lifespans than men. This groundbreaking discovery reveals the pivotal role of ncRNAs in driving lifespan evolution and provides a fundamental foundation for the study of longevity and aging.

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Why Gilgamesh failed: the mechanistic basis of the limits to human lifespan

Cited by 10 publications

References 83 publications

The machine-like repair of aging. Disentangling the key assumptions of the SENS agenda

The machine-like repair of aging. Disentangling the key assumptions of the SENS agenda

Elegant Aging Through Endocrine Optimization

Noncoding RNAs evolutionarily extend animal lifespan

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