Why are there so few effective treatments for pigmentary disorders of the skin?

Halder, Rebat M.; Rodney, Ife J.

doi:10.1586/edm.12.9

Cited by 4 publications

(4 citation statements)

References 27 publications

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“…This often results in more profound and long-lasting grayish brown hyperpigmentation. 4 PIH is also associated with adverse psychological effects. 5 To minimize this, the most crucial step lies in prevention using sunscreen, corticosteroid and epidermal cooling devices.…”

Section: Introductionmentioning

confidence: 99%

A Randomized, Double Blinded, Split-Face Study of the Efficacy of Using a Broad Spectrum Sunscreen with Anti-Inflammatory Agent to Reduce Post Inflammatory Hyperpigmentation After Picosecond Laser

Puaratanaarunkon¹,

Asawanonda²

2022

CCID

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Background Post inflammatory hyperpigmentation (PIH) is a sequela of laser procedures observed commonly in darker-skin individuals. In general, regular UV filters are beneficial in preventing PIH, but the comparison with sunscreen containing anti-inflammatory ingredients remains unexplored. Objective To compare the efficacy of a sunscreen with anti-inflammatory agent (sunscreen A) in the reduction of PIH after a picosecond laser with that of regular sunscreen (sunscreen B). Methods Fifty-nine acne vulgaris and acne scar patients with skin phototypes III and IV were treated with 1 session of picosecond laser with the microlens array to the whole face. Sunscreens A and B were randomized to be applied on either side of the face. Hyperpigmentation assessed by brown score mode on Visia ® , acne quantity, porphyrins and patient satisfaction were evaluated at baseline, weeks 1, 2, 4 and 6. Results Sunscreen A caused a higher reduction of the brown score compared to the other side but there was no statistically significant difference. Interestingly, a significant decrease of inflammatory acne lesions compared with baseline was observed as early as week 2 on the sunscreen A side (weeks 2, 4 and 6; P = 0.017, P = <0.001, and P = <0.001, respectively). Compared with sunscreen B, levels of porphyrins on sunscreen A side were significantly less at weeks 1 and 6 (weeks 1 and 6; P = 0.022 and P = 0.029, respectively). Conclusion This study demonstrated a tendency towards lower post-laser pigmentation when the sunscreen with anti-inflammatory agents was applied. This product also had an effective outcome as an adjunctive treatment option of acne vulgaris. Thai Clinical Trials Registry ID TCTR20210305004 (URL: http://www.thaiclinicaltrials.org/show/TCTR20210305004 ).

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Section: Introductionmentioning

confidence: 99%

A Randomized, Double Blinded, Split-Face Study of the Efficacy of Using a Broad Spectrum Sunscreen with Anti-Inflammatory Agent to Reduce Post Inflammatory Hyperpigmentation After Picosecond Laser

Puaratanaarunkon¹,

Asawanonda²

2022

CCID

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“…1 Deep learning algorithms based on convolutional neural networks can detect melanoma with sensitivity and specificity similar to expert dermatologists. 2,3 Such approaches are limited by the fact that perfect discrimination between benign and malignant lesions may not be achievable using visual information alone. Many lesions, particularly dysplastic naevi, require biopsy despite a low probability of melanoma in an individual lesion.…”

Section: Supporting Informationmentioning

confidence: 99%

“…1 Pigmentary disorders resulting in change of skin colour can impact patient quality of life and patient psychosocial identity due to the visibility of the cutaneous surface. 2 Disorders of hyperpigmentation are often due to localised, cutaneous change, but can also be a result of systemic disease. 3 Whilst some pigmentation disorders can be readily attributed to sun exposure, drug reactions or inflammation, in many cases an aetiology is not clear (and may be multifactorial).…”

mentioning

confidence: 99%

“…3 Whilst some pigmentation disorders can be readily attributed to sun exposure, drug reactions or inflammation, in many cases an aetiology is not clear (and may be multifactorial). 2 Furthermore, disorders of skin pigmentation pose significant challenges to both patients and clinicians, as they have the unfortunate duality of being both common and difficult to treat. 4 In 2012, Australia's first specialised pigmentary disorders clinic was established at The Skin Hospital, Darlinghurst, as a quaternary referral service for general practitioners and dermatologists to help manage difficult-to-treat conditions characterised by change in skin colour.…”

mentioning

confidence: 99%

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An analysis of patient satisfaction in a pigmentary disorders clinic from a quaternary referral service

Doolan¹,

Weaich²,

Gupta

2020

Aust J Dermatology

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Natural options for management of melasma, a review

Mpofana

Abrahamse

2018

Journal of Cosmetic and Laser Therapy

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A blemish free, even-toned skin is universally associated with healthy skin. This reasoning makes people desire to have a flawless skin. Melanin is a naturally occurring pigment in humans. This pigment is responsible for skin, hair, and eye color, therefore determines our race and phenotypic appearance. On darker skin types, it is common that melanin production processes malfunctions. These malfunctions often lead to overproduction and secretion of melanin. As a result, unwanted pigmentary problems such melasma occur. Due to unknown etiology and its recurrence in nature, melasma is challenging to treat. The current available melasma treatment options often produce undesired side effects and suboptimum results. First-line topical treatments usually involve hydroquinone or topical steroids. Apart from the irritant reactions, this treatment mode is not suitable for all skin types. Skin care specialists are in search of an effective long-term cosmetics and cosmeceuticals to address hypermelanosis problems. Understanding of naturally occurring depigmenting agents provides an opportunity for more effective ways to manage melasma in all skin types. This review considers the benefits of naturally occurring ingredients which could help address skin pigmentation problems and broaden the choice for skin-lightening treatments.

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Why are there so few effective treatments for pigmentary disorders of the skin?

Cited by 4 publications

References 27 publications

A Randomized, Double Blinded, Split-Face Study of the Efficacy of Using a Broad Spectrum Sunscreen with Anti-Inflammatory Agent to Reduce Post Inflammatory Hyperpigmentation After Picosecond Laser

A Randomized, Double Blinded, Split-Face Study of the Efficacy of Using a Broad Spectrum Sunscreen with Anti-Inflammatory Agent to Reduce Post Inflammatory Hyperpigmentation After Picosecond Laser

An analysis of patient satisfaction in a pigmentary disorders clinic from a quaternary referral service

Natural options for management of melasma, a review

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