A Randomized, Double Blinded, Split-Face Study of the Efficacy of Using a Broad Spectrum Sunscreen with Anti-Inflammatory Agent to Reduce Post Inflammatory Hyperpigmentation After Picosecond Laser

Puaratanaarunkon, Thanaporn; Asawanonda, Pravit

doi:10.2147/ccid.s355329

Cited by 8 publications

(11 citation statements)

References 17 publications

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“…A recent RCT ( n = 59) showed a reduction of inflammatory facial acne lesions as early as Week 2 with the use of a sunscreen containing anti‐inflammatory agents. The application of a regular broad‐spectrum sunscreen yielded similar results, but somewhat later (Week 6) 79 …”

Section: Resultsmentioning

confidence: 70%

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Sun exposure, a relevant exposome factor in acne patients and how photoprotection can improve outcomes

Piquero-Casals¹,

Morgado‐Carrasco

Rozas‐Muñoz

et al. 2023

J of Cosmetic Dermatology

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Background Acne pathophysiology includes a complex interaction among inflammatory mediators, hyperseborrhea, alteration of keratinization and follicular colonization by Propionibacterium acnes. Aims To describe the impact of the exposome on acne and how photoprotection can improve outcomes. Methods A narrative review of the literature was carried out; searches with Google Scholar and Pubmed from January 1992 to November 2022 were performed. The keywords used were “acne,” “sunscreens,” “photoprotection,” “cosmetics,” “cosmeceuticals,” “pathogenesis,” “etiology,” “exposome,” “sunlight,” “stress,” “lack of sleep,” “diet,” “postinflammatory hyperpigmentation,” “pollution,” “exposome,” “ultraviolet radiation,” and “visible light.” Results Environmental factors such as solar radiation, air pollution, tobacco consumption, psychological stress, diverse microorganisms, nutrition, among others, can trigger or worsen acne. Solar radiation can temporarily improve lesions. However, it can induce proinflammatory and profibrotic responses, and produce post‐inflammatory hyperpigmentation and/or post‐inflammatory erythema. While photoprotection is widely recommended to acne patients, only four relevant studies were found. Sunscreens can significantly improve symptomatology or enhance treatment and can prevent post‐inflammatory hyperpigmentation. Furthermore, they can provide camouflage and improve quality of life. Based on acne pathogenesis, optimal sunscreens should have emollient, antioxidant and sebum controlling properties. Conclusions The exposome and solar radiation can trigger or worsen acne. UV light can induce post‐inflammatory hyperpigmentation/erythema, and can initiate flares. The use of specifically formulated sunscreens could enhance adherence to topical or systemic therapy, camouflage lesions (tinted sunscreens), decrease inflammation, and reduce the incidence of post‐inflammatory hyperpigmentation/erythema.

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Section: Resultsmentioning

confidence: 70%

“…Regarding the role of sunscreens in preventing PIH in patients with acne, a recent RCT ( n = 59) on patients with inflammatory acne and/or acne scars showed a tendency towards lower post‐laser PIH when a broad‐spectrum sunscreen with anti‐inflammatory properties was used 79 …”

Section: Resultsmentioning

confidence: 99%

Sun exposure, a relevant exposome factor in acne patients and how photoprotection can improve outcomes

Piquero-Casals¹,

Morgado‐Carrasco

Rozas‐Muñoz

et al. 2023

J of Cosmetic Dermatology

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“…27,28 Laser pigmentation removal To treat hyperpigmentation, nanosecond Q-switched lasers or picosecond PIC lasers may be used. 29,30 These lasers deliver energy preferentially absorbed by endogen pigment over an extremely short duration causing the destruction of the target. The target can be epidermal such as lentigines, caféau-lait macules, Becker's nevus or dermal such as a nevus of Ota.…”

Section: Laser Tattoo Removalmentioning

confidence: 99%

“…To treat hyperpigmentation, nanosecond Q‐switched lasers or picosecond PIC lasers may be used 29,30 . These lasers deliver energy preferentially absorbed by endogen pigment over an extremely short duration causing the destruction of the target.…”

Section: Part 1: Non‐surgical Proceduresmentioning

confidence: 99%

Expert recommendations on supportive skin care for non‐surgical and surgical procedures

Amici

Cogrel

Jourdan³

et al. 2023

Acad Dermatol Venereol

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A thorough knowledge of non‐surgical procedures (laser, peelings, injections, threads) and surgical procedures (combined surgeries and skin grafts), including contraindications and potential risks and side effects, (e.g. infection, hypopigmentation, hyperpigmentation, and scarring) is essential to be able to reduce their incidence and ensure the patient receives the most benefit from the procedure. Individuals with darker skin and of high Fitzpatrick phototype are at higher risk of dyschromias, notably melasma and post‐inflammatory hyperpigmentation, which may be treated using aesthetic procedures but may also arise as a complication of some procedures. A group of experts in cosmetic surgery and dermatology reviewed the published literature and discussed recommendations for optimizing outcomes with practical advice on supportive skincare before, during and after non‐surgical or surgical procedures. A broad‐spectrum sunscreen with a high sun protection factor against UVB and high protection against UVA, especially long UVA, is essential for all treatment modalities for the prevention and potential improvement of pigmentation disorders. Supportive skin care management to prepare, cleanse and protect the skin and post‐procedure skin care with healing and anti‐inflammatory ingredients are recommended to speed up regeneration and wound healing whilst minimizing scarring and downtime. Additionally, adjunctive skin care to procedures with antioxidant, anti‐ageing and lightening properties may enhance skin benefits.

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“…The protective effect can be achieved with broad-spectrum filters against UVB, UVA and visible light, alternatively with additive anti-inflammatory and antioxidant ingredients. 61 , 62 UVR exposure is also a major extrinsic factor responsible for premature aging of the skin. Both UVB and UVA can cause DNA damage and inflammation mediated by oxidative stress.…”

Section: Hyperpigmentation and Inflammation: Link To Skin Agingmentioning

confidence: 99%

Post-Inflammatory Hyperpigmentation in Dark Skin: Molecular Mechanism and Skincare Implications

Markiewicz¹,

Karaman-Jurukovska²,

Mammone³

et al. 2022

CCID

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Human skin is characterized by significant diversity in color and tone, which are determined by the quantity and distribution of melanin pigment in the epidermis. Melanin absorbs and reflects ultraviolet radiation (UVR), preventing the damage to genomic DNA in the epidermis and degradation of collagen in the dermis; therefore, darker skin types are thought to be well protected from the photodamage because of the high melanin content. However, increased content of melanin in combination with the extrinsic stress factors causing inflammation such as excess UVR, allergic reactions, or injury can also frequently lead to cosmetic problems resulting in discoloration and scarring. This review summarizes current knowledge on histopathology and likely molecular signatures of one of the most common problems, post-inflammatory hyperpigmentation (PIH). The mechanisms proposed so far are subsequently discussed in the context of other factors characterizing darker skin types. This includes the common cellular features, organization of upper skin layers, and major biomarkers, with particular emphasis on increased propensities to systemic and localized inflammation. Enhanced or prolonged inflammatory responses can not only affect the process of melanogenesis but also have been implicated in injury-related skin pathologies and aging. Finally, we summarize the major cosmetic treatments for PIH and their known anti-inflammatory targets, which can be beneficial for darker skin tones and combined with broad-spectrum filters against UVR.

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A Randomized, Double Blinded, Split-Face Study of the Efficacy of Using a Broad Spectrum Sunscreen with Anti-Inflammatory Agent to Reduce Post Inflammatory Hyperpigmentation After Picosecond Laser

Cited by 8 publications

References 17 publications

Sun exposure, a relevant exposome factor in acne patients and how photoprotection can improve outcomes

Sun exposure, a relevant exposome factor in acne patients and how photoprotection can improve outcomes

Expert recommendations on supportive skin care for non‐surgical and surgical procedures

Post-Inflammatory Hyperpigmentation in Dark Skin: Molecular Mechanism and Skincare Implications

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