Why are serum magnesium levels lower in Saudi dialysis patients?

Mitwalli, Ahmed

doi:10.1016/j.jtumed.2016.08.008

Cited by 4 publications

(5 citation statements)

References 17 publications

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“…The hypomagnesium level was observed only in one patient. In a study by Ahmed H. Mitwalli et al 8 on serum magnesium (Mg) levels in CRF patients observed 10 patients (8.7%) had Mg levels of <0.7 mmol/L while 26 (23.9%) showed levels of >1.1 mmol/L. In the present study, it was observed that serum magnesium before dialysis was more (4.34± 1.38) compared to after dialysis (2.67 ±0.98) of patients with statistically significant correlation (p<0.05).…”

Section: Resultsmentioning

confidence: 99%

A Study of Serum Magnesium Level in Patients with Chronic Renal Failure at Tertiary Care Hospital

Patel¹,

Redkar²,

Kulkarni³

et al. 2018

IJCMR

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Introduction: CKD represents a progressive irreversible decline in the glomerular filtration rate (GFR). A common phenomenon in renal failure is progressive renal function loss irrespective of the underlying cause of the kidney disease. Hypermagnesaemia is often associated with undetected renal impairment and excessive oral administration of magnesium containing drugs (e.g. laxatives or antacids) or with advanced CKD. The present study was conducted to assess serum magnesium levels in cases with chronic renal failure Material and Methods: It was observational study carried out at Tertiary Institute to assess the levels of serum magnesium in chronic renal failure patients. A total of 80 patients were selected by simple random sampling with chronic renal failure. Results: It was shown that majority of patients were male (58.75%). Majority of patients were having hypertension (60%) followed by diabetes mellitus (43.75%). The serum magnesium among patients showed that majority of patients presented with hypermagnesaemia and serum magnesium level was low in patients with dialysis. Conclusion: Serum magnesium is a worthwhile tool in assessing duration of disease, morbidity and mortality in patients with chronic renal failure.

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Section: Resultsmentioning

confidence: 99%

A Study of Serum Magnesium Level in Patients with Chronic Renal Failure at Tertiary Care Hospital

Patel¹,

Redkar²,

Kulkarni³

et al. 2018

IJCMR

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“…The subjects’ serum values of Mg, TC, and TG were determined, showing that patients that underwent peritoneal dialysis had lower Mg levels compared to hemodialysis patients. The correlation studies did not find statistically significant associations between Mg and TC or TG variations [ 130 ]. While studying the association of hypomagnesemia with increased mortality among patients that underwent peritoneal dialysis in a research which included two hundred and fifty three subjects, Cai et al (2016) reported a positive association between low serum Mg and TG (r = 0.160, p = 0.011), but the correlation with TC did not reach statistical significance ( p = 0.929) [ 131 ].…”

Section: Resultsmentioning

confidence: 99%

Crosstalk of Magnesium and Serum Lipids in Dyslipidemia and Associated Disorders: A Systematic Review

et al. 2021

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Dyslipidemia is a significant threat to public health worldwide and the identification of its pathogenic mechanisms, as well as novel lipid-lowering agents, are warranted. Magnesium (Mg) is a key element to human health and its deficiency has been linked to the development of lipid abnormalities and related disorders, such as the metabolic syndrome, type 2 diabetes mellitus, or cardiovascular disease. In this review, we explored the associations of Mg (dietary intake, Mg concentrations in the body) and the lipid profile, as well as the impact of Mg supplementation on serum lipids. A systematic search was computed in PubMed/MEDLINE and the Cochrane Library and 3649 potentially relevant papers were detected and screened (n = 3364 following the removal of duplicates). After the removal of irrelevant manuscripts based on the screening of their titles and abstracts (n = 3037), we examined the full-texts of 327 original papers. Finally, after we applied the exclusion and inclusion criteria, a number of 124 original articles were included in this review. Overall, the data analyzed in this review point out an association of Mg concentrations in the body with serum lipids in dyslipidemia and related disorders. However, further research is warranted to clarify whether a higher intake of Mg from the diet or via supplements can influence the lipid profile and exert lipid-lowering actions.

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“…Previous experimental studies showed oral vitamin D in the treatment regimens had no significant effect on increasing serum Mg levels in laboratory samples (20)(21)(22)(23)(24)(25). In an experimental study on vitamin D deficient mice, the mice were assigned to six groups, each group receiving one of the 1,25-dihydroxyvitamin D3, 1,24,25-trihydroxyvitamin D3, 24,25-dihydroxyvitamin D3, a combination of the last two regimens, or vehicle (-D) for six days.…”

Section: Discussionmentioning

confidence: 98%

“…High doses of 25-hydroxyvitamin D increase Mg absorption; however, Mg is also absorbed regardless of vitamin D and its intestinal receptor (11). According to previous studies, several factors such as diabetes, certain medications, PPIs, thiazide diuretics, cisplatin, aminoglycoside antibiotics and calcineurin inhibitors (4,7,8), tubular defects (1) and type of dialysis (23) affect changes in Mg levels and the incidence of hypomagnesemia.…”

Section: Discussionmentioning

confidence: 99%

Effect of vitamin D treatment on magnesium levels in chronic hemodialysis patient; a double blind controlled clinical trial

et al. 2022

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Introduction: The homeostasis of magnesium (Mg) is impaired in chronic kidney disease (CKD) and it has been suggested that intestinal absorption of Mg may be affected by vitamin D status. 25-Hydroxy vitamin D or 25(OH)D deficiency is common in patients undergoing chronic hemodialysis; however the efficacy of nutritional vitamin D supplementation on Mg level in this population remains uncertain. Objectives: The aim of this study was to evaluate the effect of vitamin D treatment on Mg levels in chronic hemodialysis patients. Patients and Methods: This randomized clinical trial study was conducted on 69 chronic hemodialysis patients (mean age of 56.93 ±12.26 years) with serum 25-hydroxy vitamin D levels <30 ng/mL. The patients were randomly assigned to one of treatment groups of oral vitamin D3- 50 000 units per week (n=35; experimental group) or 500 mg calcium D3 tablets, every 12 hours (n=34; control group) for three months. At the beginning and end of the treatment period, the levels of serum 25-hydroxy vitamin D and the levels of Mg, calcium, phosphorus and intact parathyroid hormone (iPTH) were measured in two groups. Results: In both groups, serum vitamin D levels increased significantly after treatment (P<0.0001 for both groups), however after three months of treatment, in the experimental group the levels of vitamin D were significantly higher than the patients in the control group (57 ng/mL versus 28 ng/mL; P<0.0001) and the median increase of vitamin D after treatment in the experimental group was significantly higher than the control group (40 ng/mL versus 10.5; P<0.0001). Serum Mg levels before and after treatment were not significantly different between two groups (P=0.880 and P=0.434). In this study, we found no significant correlation between serum vitamin D level with serum Mg, calcium, phosphate, and parathyroid Hormone levels (P>0.05). Conclusion: Our study shows that oral vitamin D therapy can increase 25(OH)D levels in maintenance hemodialysis patients without significant alterations in serum calcium, phosphate, magnesium and parathyroid hormone during a 12-week period. Trial Registration: Registration of trial protocol has been approved by the Iranian registry of clinical trial (#IRCT20210314050698N1; https://en.irct.ir/trial/55159, local ethical code# IR.SKUMS.REC.1397.181).

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Why are serum magnesium levels lower in Saudi dialysis patients?

Cited by 4 publications

References 17 publications

A Study of Serum Magnesium Level in Patients with Chronic Renal Failure at Tertiary Care Hospital

A Study of Serum Magnesium Level in Patients with Chronic Renal Failure at Tertiary Care Hospital

Crosstalk of Magnesium and Serum Lipids in Dyslipidemia and Associated Disorders: A Systematic Review

Effect of vitamin D treatment on magnesium levels in chronic hemodialysis patient; a double blind controlled clinical trial

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