Whole salivary flow rates following submandibular gland resection

Jacob, Rhonda F.; Weber, Randal S.; King, Gordon E.

doi:10.1002/(sici)1097-0347(199605/06)18:3<242::aid-hed6>3.0.co;2-#

Cited by 44 publications

(43 citation statements)

References 10 publications

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“…Despite the lack of a standardized procedure, the results of different study groups are fairly comparable. Healthy persons at physical rest have a salivary flow rate of > 0.4 ml/min which can be enhanced up to > 5 ml/min by stimulation [10,25]. Stimulated salivary flow rates of patients with radiation-induced xerostomia, as seen in this study, show much lower values, which are often below the measuring limit.…”

Section: Discussionmentioning

confidence: 50%

“…Only few is known about the clinical consequence of radiation damage, which also affects the "small" salivary glands throughout the oral mucosa [12]. Endpoints of clinical studies using salivary flow become even more difficult to interpret, if the high prevalence of xerostomia in nonirradiated, (subjectively) healthy patients (up to 25%) [1] and the role of surgical removal of major salivary glands [25] are taken into account. Regarding these difficulties, it seems obvious why higher lower salivary flow rates in the test arms of randomized clinical studies are not always represented by better patient-related outcomes [16].…”

Section: Discussionmentioning

confidence: 99%

“…We collected stimulated saliva for 5 min in a quiet room outside the medical ambulance in the morning period between 09:00 a.m. and 01:00 p.m. To avoid additional discomfort for the patients when chemical stimulation with citric acid seemed to be impossible (ten cases), we used suggestion techniques to stimulate the flow. If present, the amount of foam was consequently recorded together with the liquid [25]. Total amounts < 0.02 ml/min stimulated flow or patients with total xerostomia (RTOG grade 3) were rated as 0.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Quantifying Radioxerostomia: Salivary Flow Rate, Examiner’s Score, and Quality of Life Questionnaire

Al‐Nawas

Al-Nawas²,

Kunkel³

et al. 2006

Strahlenther Onkol

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Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Quantifying Radioxerostomia: Salivary Flow Rate, Examiner’s Score, and Quality of Life Questionnaire

Al‐Nawas

Al-Nawas²,

Kunkel³

et al. 2006

Strahlenther Onkol

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“…Jacob et al 16 compared the salivary flow rates in 29 patients who had undergone unilateral gland resection and 8 patients who underwent bilateral gland resection, with 29 control patients. Unstimulated and stimulated (paraffin) flow rates were significantly lower in both resection groups compared with the control group.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Metastases in the Submandibular Gland in Head and Neck Malignancy

Kruse

Grätz

2009

Journal of Craniofacial Surgery

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(15), atrophy (5), tumor infiltration (5), and intraglandular lymph node (1). In the group with sialadenitis, the mean age was 57.7 years. Forty-four percent had a pretreatment (radiation, 9%; local resection, 13%; or combined therapy, 22%) before neck dissection. Of the sialadenitis group, 9 of 12 patients had the primary tumor in the lower jaw, floor of mouth, or tongue. CONCLUSIONS:: One needs to be aware of the possibility of occult metastases in level I in oral cavity carcinomas, whereas oropharynx carcinoma constitutes a lower risk for involvement of lymph node metastases at level I. The excision of the submandibular gland should be performed in cases with positive lymph nodes at level I and in tumor sites with a high risk of occult metastasis at level I. (15), atrophy (5), tumor infiltration (5) and intraglandular lymph node (1). In the group with sialadenitis, the mean age was 57.7 years. Evaluation of Metastases in Submandibular Gland in Head andForty-four percent had a pretreatment (radiation 9%, local resection 13% or combined therapy 22%) before neck dissection. Of the sialadentitis group, 9 of 12 patients had the primary tumor in the lower yaw, floor of mouth or tongue. Conclusion:One needs to be aware of the possibility of occult metastases in level I in oral cavity carcinomas, whereas oropharynx carcinoma constitutes a lower risk for involvement of lymph node metastases in level I. The excision of the submandibular gland should be performed in cases with positive lymph nodes at level I and in tumor sites with a high risk of occult metastasis at level I.

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“…Murdoch-Kinch et al [5] reported that submandibular gland salivary function decreases significantly after a mean dose of [40 Gy of radiation exposure. As the submandibular glands are responsible for a significant amount of the basal salivary flow [6], we actually should assess the implications of keeping it intact or its removal.…”

Section: Introductionmentioning

confidence: 99%

Questionable Necessity for Removing Submandibular Gland in Neck Dissection in Squamous Cell Carcinoma of Oral Cavity

Agarwal

Nagpure

Chavan

2016

Indian J Otolaryngol Head Neck Surg

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To assess whether submandibular gland is involved by metastasis in cases of oral cavity squamous cell carcinomas. It was a retrospective study, where we reviewed the records of the patients who underwent neck dissections for Squamous Cell Carcinoma of the oral cavity. It included 112 patients who had undergone 115 neck dissections (three patients had undergone bilateral neck dissection), either therapeutic or prophylactic. No pathologic evidence of metastasis to submandibular gland was seen in any of the case. Preservation of submandibular glands can be a good technique for reducing future complications in a patient undergoing Neck Dissection wherever feasible. Therefore, if there is no need to expose large oral cavity tumors through the submandibular triangle, or when there is no direct extension of the primary and/or regional lymph nodes into the submandibular gland, it may be safe to preserve the submandibular gland.

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Whole salivary flow rates following submandibular gland resection

Cited by 44 publications

References 10 publications

Quantifying Radioxerostomia: Salivary Flow Rate, Examiner’s Score, and Quality of Life Questionnaire

Quantifying Radioxerostomia: Salivary Flow Rate, Examiner’s Score, and Quality of Life Questionnaire

Evaluation of Metastases in the Submandibular Gland in Head and Neck Malignancy

Questionable Necessity for Removing Submandibular Gland in Neck Dissection in Squamous Cell Carcinoma of Oral Cavity

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