Quantifying Radioxerostomia: Salivary Flow Rate, Examiner’s Score, and Quality of Life Questionnaire

Al‐Nawas, Bilal; Al-Nawas, Katy; Kunkel, Martin; Grötz, K. A.

doi:10.1007/s00066-006-1508-x

Cited by 40 publications

(37 citation statements)

References 46 publications

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“…The restrictive coverage of level I/upper level II (Tables 5 and 6) eases sparing mucosal, parotid gland, and mandible bone tissue [1,14,15,27]. None of the patients failed in these areas.…”

Section: Discussionmentioning

confidence: 99%

Locoregional Failure Analysis in Head-and-Neck Cancer Patients Treated with IMRT

2007

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Purpose: Analysis of locoregional failure in head-and-neck cancer (HNC) following intensity-modulated radiation therapy (IMRT), with focus on the location of locoregional failures in relation to the chosen planning target volumes (PTVs) and dose distributions. Patients and Methods: Between January 2002 and May 2006, 280 HNC patients were subjected to IMRT at the authors' institution. Mean follow-up was 23.2 months (3-59.3 months). Definitive IMRT was performed in 75% of all patients. In 71%, simultaneous cisplatin-based chemotherapy was given. 70% of patients presented with T3/4, T1-2 N2c/3 or recurred disease. Locoregional failure patterns were analyzed. Results: 2-year local, nodal, distant, disease-free, and overall survival rates were 80%, 87%, 87%, 73%, and 82%, respectively. 46 local (16%) and 31 nodal (11%) failures have been observed so far. Local tumor persistence was seen in 23/46 cases (50%), and nodal persistence in 12/31 (39%), respectively. One marginal local failure developed in a patient referred for a recurred oral cavity tumor. Three nodal failures developed outside the PTVs at unexpected locations. All other failures have been confirmed "in field". No failure occurred in level Ib or upper level II. Local failure occurred mainly following definitive IMRT for large tumors, nodal failure only in nodally positive patients with nodal high-risk features. Conclusion:The dose-volume concept as used here has shown to be adequate, with disease failure developing at the site of the initial gross tumor manifestation inside the boost volume.

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Section: Discussionmentioning

confidence: 99%

Locoregional Failure Analysis in Head-and-Neck Cancer Patients Treated with IMRT

2007

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“…Patients filled in the EORTC quality of life questionnaire before, at the end of treatment, and every 4 months during follow-up [2]. The data were analyzed, but seven patients is too small a group to draw conclusions.…”

Section: Subjective Scoring Of Salivary Gland Functionmentioning

confidence: 99%

Longitudinal Assessment of Parotid Function in Patients Receiving Tomotherapy for Head-and-Neck Cancer

Voordeckers

Everaert²,

Tournel³

et al. 2008

Strahlenther Onkol

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“…In addition to the desirable anticancer effects, ionizing radiation causes damage to normal tissues located within the irradiation fields [4,7,18,23]. Signs and symptoms include mucositis, hyposalivation, and impaired gustation [8,9,14].…”

Section: Introductionmentioning

confidence: 99%

Proof of Direct Radiogenic Destruction of Collagen in Vitro

et al. 2007

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Quantifying Radioxerostomia: Salivary Flow Rate, Examiner’s Score, and Quality of Life Questionnaire

Abstract: The correlation between "subjective" QoL parameters and salivary flow was confirmed. The different subjective aspects of radioxerostomia seem to be better differentiated by the EORTC QoL questionnaire.

Cited by 40 publications

References 46 publications

Locoregional Failure Analysis in Head-and-Neck Cancer Patients Treated with IMRT

Locoregional Failure Analysis in Head-and-Neck Cancer Patients Treated with IMRT

Longitudinal Assessment of Parotid Function in Patients Receiving Tomotherapy for Head-and-Neck Cancer

Proof of Direct Radiogenic Destruction of Collagen in Vitro

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