Whole-proteome analysis of mesonephric-derived cancers describes new potential biomarkers

Gibbard, Evan; Cochrane, Dawn R.; Pors, Jennifer; Colborne, Shane; Cheng, Angela; Chow, Christine; Farnell, David; Tessier‐Cloutier, Basile; McAlpine, Jessica N.; Morin, Gregg B.; Schmidt, Dietmar; Kommoss, Stefan; Kommoss, Friedrich; Keul, Jacqueline; Huntsman, David G.; Hoang, Lynn

doi:10.1016/j.humpath.2020.10.005

Cited by 7 publications

(10 citation statements)

References 37 publications

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“…Howitt et al compared GATA3 expression in mesonephric/Wolffian remnant with other tumors of the female genital tract. They found that GATA3 has a sensitivity of 98% and a specificity of 98% to differentiate mesonephric lesions to endocervical and endometrial carcinomas [20], which was confirmed by the whole proteome analysis by Gibbard et al [5]. Later Pors et al compared the sensitivity and specificity of GATA3, TTF1, CD10 and calretinin in the diagnosis of MLAs and reported GATA3 to be the best overall marker, but staining can be weak to moderate in intensity and positive in only a minority of cells (<10%) [27].…”

Section: Immunohistochemistrymentioning

confidence: 71%

“…With the morphology reminiscent of classic mesonephric carcinoma and overlapping immunohistochemical features, it could be a type of mesonephric carcinoma with divergent Müllerian features. Proteomic analysis of both MA and MLA was as good as identical [5]. On the other hand, uterine tumors tend to originate from the endometrium with secondary involvement of the myometrium and they are not associated with mesonephric remnants.…”

Section: Pathogenesismentioning

confidence: 77%

“…There are a handful of cases where MLA is associated with other Müllerian neoplasms and clonality between the two is proven as they share identical KRAS or NRAS mutations [3,4]. Whole proteomic analysis, however, could not distinguish MA from MLA [5]. Most importantly, MLA is often misdiagnosed as other endometrial neoplasms, but has an aggressive clinical behavior and tend to metastasize early to the lungs [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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Mesonephric-Like Adenocarcinoma of the Endometrium: Diagnostic Advances to Spot This Wolf in Sheep’s Clothing. A Review of the Literature

Deolet

Dorpe

Vijver

2021

JCM

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Mesonephric-like adenocarcinoma is a recently described rare neoplasm occurring in the uterine corpus and ovary. This under-recognized subtype of carcinoma can be very challenging to diagnose. In mesonephric adenocarcinoma a variety of growth patterns can be present within the same tumor, as a result of which they can be misinterpreted and diagnosed as low-grade endometrioid adenocarcinoma, clear cell carcinoma, or even serous carcinoma and carcinosarcoma. We report a case of mesonephric-like adenocarcinoma misdiagnosed as a low-grade endometrioid endometrial adenocarcinoma that had an early local recurrence and metastasized to the liver and the lungs. Histopathological, immunohistochemical and molecular analysis were performed and compared to published literature, providing a comprehensive overview of the current knowledge. Databases (Pubmed, Web of Science, Google Scholar) were searched with a combination of the following search terms: mesonephric-like, mesonephric, adenocarcinoma, carcinoma, uterine body, uterine corpus, endometrium. Mesonephric-like adenocarcinoma is a difficult-to-diagnose entity. Advanced diagnostics, including improved morphologic, immunohistochemical and molecular knowledge can help develop new therapeutic strategies against this specific subtype of endometrial cancer with an aggressive clinical behavior.

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Section: Immunohistochemistrymentioning

confidence: 71%

Section: Pathogenesismentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

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Mesonephric-Like Adenocarcinoma of the Endometrium: Diagnostic Advances to Spot This Wolf in Sheep’s Clothing. A Review of the Literature

Deolet

Dorpe

Vijver

2021

JCM

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“…As for female reproductive systems, GATA3 can be a useful immunohistochemical marker for diagnosis of mesonephric-like carcinoma of the endometrium in the uterus and endometriosis [55][56][57]. Since GATA3 is developmentally required for genesis of Müllerian duct-derived organs such as the uterus, it is important to address whether alteration of GATA3 activity participates in uterine carcinogenesis.…”

Section: Gata3 and Urogenital Cancersmentioning

confidence: 99%

Development and Carcinogenesis: Roles of GATA Factors in the Sympathoadrenal and Urogenital Systems

Moriguchi

2021

Biomedicines

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The GATA family of transcription factors consists of six proteins (GATA1-6) that control a variety of physiological and pathological processes. In particular, GATA2 and GATA3 are coexpressed in a number of tissues, including in the urogenital and sympathoadrenal systems, in which both factors participate in the developmental process and tissue maintenance. Furthermore, accumulating studies have demonstrated that GATA2 and GATA3 are involved in distinct types of inherited diseases as well as carcinogenesis in diverse tissues. This review summarizes our current knowledge of how GATA2 and GATA3 participate in the transcriptional regulatory circuitry during the development of the sympathoadrenal and urogenital systems, and how their dysregulation results in the carcinogenesis of neuroblastoma, renal urothelial, and gynecologic cancers.

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“…Cervical MA is typically associated with mesonephric remnant or hyperplasia and is characterized by various growth patterns, including small tubules and glands with intraluminal eosinophilic secretions admixed with papillary, retiform, or solid architecture [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. It also has a unique immunophenotype displaying positive immunoreactivities for GATA-binding protein 3 (GATA3), paired box 2 (PAX2), lack of hormone receptor expression, wild-type p53 immunostaining pattern, and preserved phosphatase and tensin homolog deleted on chromosome 10 (PTEN) immunoreactivity [ 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. In addition, most MAs characteristically harbor somatic mutations of Kirsten rat sarcoma 2 viral oncogene homolog ( KRAS ) [ 8 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Serous Carcinoma of the Endometrium with Mesonephric-Like Differentiation Initially Misdiagnosed as Uterine Mesonephric-Like Adenocarcinoma: A Case Report with Emphasis on the Immunostaining and the Identification of Splice Site TP53 Mutation

2021

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We present herein a rare case of uterine serous carcinoma with mesonephric-like differentiation (SC-MLD) initially misdiagnosed as mesonephric-like adenocarcinoma (MLA). A 51-year-old woman underwent total hysterectomy for a uterine tumor. Histologically, the tumor exhibited various architectures, including papillary, glandular, tubular, cribriform, and cystic. On the basis of this architectural diversity accompanied by intraluminal eosinophilic secretions and intermediate-grade nuclear atypia, the initial diagnosis was MLA. However, the tumor was diffusely and strongly positive for the expression of p16 and negative for the expression of GATA-binding protein 3 (GATA3). Furthermore, we identified a pathogenic tumor protein 53 (TP53) mutation affecting an acceptor splice site in intron 9, despite a wild-type p53 immunostaining pattern. The observations of diffuse and strong p16 expression, lack of GATA3 expression, pathogenic TP53 mutation, and wild-type Kirsten rat sarcoma viral oncogene homolog indicate that this tumor was not an MLA but an SC-MLD. Both uterine SC and MLA can exhibit various histological growth patterns. Our comprehensive clinicopathological and molecular analyses can serve to improve the understanding of this rare condition and help pathologists in making an accurate diagnosis.

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Whole-proteome analysis of mesonephric-derived cancers describes new potential biomarkers

Cited by 7 publications

References 37 publications

Mesonephric-Like Adenocarcinoma of the Endometrium: Diagnostic Advances to Spot This Wolf in Sheep’s Clothing. A Review of the Literature

Mesonephric-Like Adenocarcinoma of the Endometrium: Diagnostic Advances to Spot This Wolf in Sheep’s Clothing. A Review of the Literature

Development and Carcinogenesis: Roles of GATA Factors in the Sympathoadrenal and Urogenital Systems

Serous Carcinoma of the Endometrium with Mesonephric-Like Differentiation Initially Misdiagnosed as Uterine Mesonephric-Like Adenocarcinoma: A Case Report with Emphasis on the Immunostaining and the Identification of Splice Site TP53 Mutation

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