Whole organism biocatalysis

Bioreduction of Some Common Carbonylic Compounds Mediated by Yeasts

“…Reduction of prochiral carbonyl precursors to chiral sec-alcohols is special enzymatic reaction where cells have been also used (Goldberg et al, 2007). Chiral alcohols are very useful materials especially in the chemical and pharmaceutical industries, where enantiopurity of drugs or building blocks synthesis is highly relevant (Chartrain et al, 2001;Ishige et al, 2005).…”

Biotransformation of a cage-like diels-alder adduct and derivatives by Mucor ramosissimus samutsevitsch

“…Biocatalytic processes for the synthesis of chemicals of industrial value have been attracting much attention as an environmental-friendly procedure (5). Bacteria and fungi have been used to produce chemicals, pharmaceuticals and perfumes during recent years (1).…”

“…Whole microbial cells play an important role in organic synthesis field because of their diversity. Several microorganisms with unique catalytic abilities have been found by intensive screening and put to practical use (5). Moreover, the biotransformation may lead to substitution at chemically inaccessible sites without perturbing the underlying carbon skeleton of the substrate (2).…”

Mandelate Racemase and Mandelate Dehydrogenase Coexpressed RecombinantEscherichia coliin the Synthesis of Benzoylformate

“…It makes possible the use of cells as ''bags stuffed with catalysts.'' 24) To our knowledge, BA is more expensive than racemic mandelate [(AE)-MA] in the chemical market. In this study, the genes encoding mandelate racemase and mandelate dehydrogenase from Pseudomonas aeruginosa were cloned and expressed in E. coli.…”