Whole genome sequencing identifies zoonotic transmission of MRSA isolates with the novel
            <i>mecA</i>
            homologue
            <i>mecC</i>

Harrison, Ewan M.; Paterson, Gavin K.; Holden, Matthew T. G.; Larsen, Jesper; Stegger, Marc; Larsen, Anders Rhod; Petersen, Andreas; Skov, Robert; Christensen, Judit Marta; Zeuthen, Anne Bak; Heltberg, Ole; Harris, Simon R.; Zadoks, Ruth N.; Parkhill, Julian; Peacock, Sharon J.; Holmes, Mark A.

doi:10.1002/emmm.201202413

Cited by 201 publications

(179 citation statements)

References 39 publications

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“…The livestock animal species involved are mainly dairy cattle, and these strains have not been recovered from pigs or poultry so far. Other animals involved include sea mammals, pet animals, wildlife (birds and mammals), and zoo animals [97][98][99][101][102][103][104][105][106]. Of note, the ST130 strains carrying SCCmec type XI are likely to be zoonotic and to cause infections in animals [98,107].…”

Section: Scc Mec Type XI Mecc-carrying Mrsa From Animalsmentioning

confidence: 99%

Livestock-Associated MRSA and Its Current Evolution

Butaye

Argudín

Smith

2016

Curr Clin Micro Rpt

116

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Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) is a relatively recent phenomenon in veterinary medicine. Although in the beginning it was restricted to a single clonal complex (CC), CC398, it has expanded into several clonal complexes, and the diversity of subtypes in the clonal complexes is increasing also. The prevalence of each type is determined somewhat geographically; for instance, the most prevalent clonal complex in Europe is CC398, whereas in Asia, it is CC9. Although few data exist regarding North America, the situation appears to be mixed there. The SCCmec cassettes detected in LA-MRSA are limited mainly to SCCmec IVa and SCCmec V, although non-typeable cassettes and SCCmec type XI, containing mecC, also have been found.The source of the SCCmec in LA-MRSA was discovered to be animals. In searching from which bacteria the SCCmec cassettes in LA-MRSA have been transferred, the most obvious species to consider are the methicillin-resistant non-S. aureus staphylococci (MRNaS). However, very few data are available from those species in animals, and the data that do exist are not detailed enough to determine the origin. Nevertheless, similar cassettes were found in MRNaS, indicating a possible origin that needs to be investigated further.

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Section: Scc Mec Type XI Mecc-carrying Mrsa From Animalsmentioning

confidence: 99%

Livestock-Associated MRSA and Its Current Evolution

Butaye

Argudín

Smith

2016

Curr Clin Micro Rpt

116

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“…MLST, pulsed-field gel electrophoresis (PFGE) and multilocus variable-number tandem repeat analysis (MLVA) were unable to distinguish between the two clusters [70].…”

Section: Application Of Genomics In Epidemiological Settings and Outbmentioning

confidence: 99%

Genomic insights into the emergence and spread of international clones of healthcare-, community- and livestock-associated meticillin-resistant Staphylococcus aureus : Blurring of the traditional definitions

Bal

Coombs

Holden

et al. 2016

Journal of Global Antimicrobial Resistance

117

105

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Please cite this article as: Bal AM, Coombs GW, Holden MTG, Lindsay JA, Nimmo GR, Tattevin P, Skov RL, Genomic insights into the emergence and spread of international clones of healthcare-, community-and livestock-associated meticillinresistant Staphylococcus aureus: blurring of the traditional definitions, Journal of Global Antimicrobial Resistance (2010), http://dx.doi.org/10.1016/j.jgar. 2016.04.004 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.  Genomics-based diagnostic tools such as whole-genome sequencing are useful in providing rapid information in relation to epidemiology and outbreaks.

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“…are also often responsible for human sporadic and epidemic cases associated with food matrices (Healy, Cooney, O'Brien, Iversen & Whyte, 2010). Moreover, Staphylococcus aureus that is responsible for the most frequent foodborne intoxication, is acquiring a new epidemiological dimension through the putative role of some foods, in particular chicken and pork, as a vehicle of livestock-associated methicillin resistant (MRSA) strains (Harrison et al 2013). …”

Section: Introductionmentioning

confidence: 99%