Whole-Exome Sequencing identified Olfactory Receptor genes as a key contributor to extreme obesity with progression to nonalcoholic steatohepatitis in Mexican patients

Torres-Reyes, LA; González-Aldaco, Karina; Panduro, Arturo; José-Ábrego, Alexis; Román, Sonia

doi:10.1016/j.aohep.2022.100767

Cited by 2 publications

(1 citation statement)

References 40 publications

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“…Some HSD17B13 variants such as the rs72613567 T > A have been associated with a protective effect in cirrhotic and HCC patients (127) as well as in European patients with ALD (128,129) and HCV patients (130). In a recent study, this polymorphism was detected in patients with extreme obesity and MASH among other gen variants related to HCC (131). However, further genetic studies are also needed for LATAM populations, including Mexico, to confirm these associations.…”

Section: Hepatocellular Carcinomamentioning

confidence: 99%

Personalized medicine and nutrition in hepatology for preventing chronic liver disease in Mexico

Panduro,

Roman,

Mariscal-Martinez

et al. 2024

Front. Nutr.

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Chronic liver disease is a global health issue. Patients with chronic liver disease require a fresh approach that focuses on the genetic and environmental factors that contribute to disease initiation and progression. Emerging knowledge in the fields of Genomic Medicine and Genomic Nutrition demonstrates differences between countries in terms of genetics and lifestyle risk factors such as diet, physical activity, and mental health in chronic liver disease, which serves as the foundation for the implementation of Personalized Medicine and Nutrition (PerMed-Nut) strategies. Most of the world’s populations have descended from various ethnic groupings. Mexico’s population has a tripartite ancestral background, consisting of Amerindian, European, and African lineages, which is common across Latin America’s regional countries. The purpose of this review is to discuss the genetic and environmental components that could be incorporated into a PerMed-Nut model for metabolic-associated liver disease, viral hepatitis B and C, and hepatocellular carcinoma in Mexico. Additionally, the implementation of the PerMed-Nut approach will require updated medicine and nutrition education curricula. Training and equipping future health professionals and researchers with new clinical and investigative abilities focused on preventing liver illnesses in the field of genomic hepatology globally is a vision that clinicians and nutritionists should be concerned about.

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