Genomic medicine in hepatology: Towards personalized medicine in obesity and chronic liver disease

Román, Sonia; Ramos-López, Omar; Panduro, Arturo

doi:10.1016/j.aohep.2022.100875

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…Finally, in the context of the global obesity epidemic including in Mexico, these results show the importance of moving toward a more personalized medicine and nutrition approach, toward assessing risk, and finding novel ways to prevent and treat diseases ( 55 ). Furthermore, the presence of the respective risk alleles among the studied genes underscores the need for preventive strategies against further weight gain among the population ( 56 ).…”

Section: Discussionmentioning

confidence: 98%

Relationship between energy balance and reward system gene polymorphisms and appetitive traits in young Mexican subjects

Rivera-Iñiguez,

Hunot-Alexander,

Sepúlveda-Villegas

et al. 2024

Front. Nutr.

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IntroductionAppetitive traits are influenced by the interplay between genetic and environmental factors. This study aimed to explore the relationship between gene polymorphisms involved in the regulation of energy balance and food reward and appetitive traits in young Mexican subjects.MethodsThis cross-sectional study involved 118 university freshman undergraduates who completed the Adult Eating Behaviour Questionnaire for Spanish speakers (AEBQ-Esp) to assess their appetitive traits. A real-time PCR system was employed to determine gene polymorphisms involved in energy balance (LEP rs7799039, MC4R rs17782313, FTO rs9939609, GHRL rs696217), and reward system (DRD2/ANKK1 Taq1A rs1800497 and COMT rs4680).ResultsThe mean age of participants was 20.14 ± 3.95 years, 71.2% were women and their mean BMI was 23.52 ± 4.05 kg/m2. COMT Met allele carriers presented a significantly higher “Emotional overeating” mean score than Val allele carriers (2.63 ± 0.70 vs. 2.23 ± 0.70, p = 0.028). The MC4R CC + CT genotype correlated positively with “Emotional overeating” (Phi = 0.308, p = 0.01). The COMT MetMet+MetVal genotype correlated with higher “Emotional overeating” (r = 0.257, p = 0.028; Phi = 0.249, p = 0.033). The protective genotype FTO TT correlated positively with “Emotional undereating” (Phi = 0.298, p = 0.012). Carriers of the risk genotype MC4R CC + CT presented a higher risk of “Emotional overeating” than TT carriers (OR = 2.4, 95% CI 1.3–4.8, p = 0.034). Carriers of the risk genotype COMT MetMet+MetVal (OR = 3.4, 95% CI 1.1–10.3, p = 0.033), were associated with a higher risk of “Emotional overeating” than ValVal carriers. The protective FTO genotype TT was associated with “Emotional undereating” (OR = 1.8, 95% CI 1.1–9.1, p = 0.014).DiscussionThe study found a relationship between the protective genotypes of FTO TT and “Emotional undereating” and risk genotypes of COMT Met/Met+Met/Val and MC4R CC + CT with “Emotional overeating.” These genetic factors may increase weight gain by enhancing hedonic food consumption and reducing satiety control. Future studies should focus on replication studies in ethnically diverse young adults and life stages to explore the relationship between polymorphisms and appetitive traits and weight. This will help tailor personalized nutrigenetic strategies to counteract disordered eating patterns leading to obesity and associated co-morbidities.

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Section: Discussionmentioning

confidence: 98%

Relationship between energy balance and reward system gene polymorphisms and appetitive traits in young Mexican subjects

Rivera-Iñiguez,

Hunot-Alexander,

Sepúlveda-Villegas

et al. 2024

Front. Nutr.

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“…Concurrently, there has been a decrease in the acquisition of unprocessed or minimally processed foods and processed culinary ingredients (87). Reversing this situation will require training and education in Genomic Nutrition to adequately prepare frontline clinicians, nutritionists, and other medical specialists to fight against these external factors and promote better eating patterns (88)(89)(90)(91)(92). In addition, research in complementary fields, including population genetics, food anthropology, social sciences, and evolutionary medicine studies, is crucial to provide an integrated framework defining the biological and cultural basis of a personalized or regionalized nutrition approach.…”

Section: The Genomex Diet: Benefits and Challengesmentioning

confidence: 99%

Personalized nutrition: the end of the one-diet-fits-all era

Roman,

Campos-Medina,

Leal-Mercado

2024

Front. Nutr.

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Personalized Nutrition emerged as a new trend for providing nutritional and food advice based on the individual’s genetic composition, a field driven by the advancements in the multi-omic sciences throughout the last century. It intends not only to tailor the recommended daily allowances of nutrients and functional foods that a person may need but also to maintain the principles of sustainability and eco-friendliness. This principle implies the implementation of strategies within the healthcare system to advocate for the ending of the one-diet-fits-all paradigm by considering a personalized diet as an ally to prevent diet-related chronic diseases. In this Perspective, we highlight the potential benefits of such a paradigm within the region of Latin America, particularly Mexico, where the genetic admixture of the population, food biodiversity, and food culture provide unique opportunities to establish personalized nutrigenetic strategies. These strategies could play a crucial role in preventing chronic diseases and addressing the challenges confronted in the region.

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Genomic medicine in hepatology: Towards personalized medicine in obesity and chronic liver disease

Cited by 2 publications

References 15 publications

Relationship between energy balance and reward system gene polymorphisms and appetitive traits in young Mexican subjects

Relationship between energy balance and reward system gene polymorphisms and appetitive traits in young Mexican subjects

Personalized nutrition: the end of the one-diet-fits-all era

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