Whole Cinnamon and Aqueous Extracts Ameliorate Sucrose-Induced Blood Pressure Elevations in Spontaneously Hypertensive Rats

Preuss, Harry G.; Echard, Bobby; Polansky, Marilyn M.; Anderson, Richard A.

doi:10.1080/07315724.2006.10719525

Cited by 82 publications

(48 citation statements)

References 38 publications

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“…Cinnamon supports healthy circulation by bringing blood from the center of the body to the skin. Results obtained from use of animals as case studies are also indicative of the ability of cinnamon to regulate blood pressure via peripheral vasodilatation [24]. This mechanism may have caused increased eGFR in the cinnamon supplementation group and may be consistent with the hypothesis of the renal cause of essential hypertension, although it can also be explained by renal damage caused by elevated BP.…”

Section: Discussionsupporting

confidence: 55%

Effect of cinnamon supplementation on glucose, lipids levels, glomerular filtration rate, and blood pressure of subjects with type 2 diabetes mellitus

Sengsuk

Sanguanwong²,

Tangvarasittichai

et al. 2015

Diabetol Int

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A randomized, double-blind, placebo-controlled trial was performed to investigate the effect of cinnamon supplementation on glucose, triglyceride (TG), and high density lipoprotein-cholesterol (HDL-C) levels, TG/HDL-C ratio, blood pressure (BP), and estimated glomerular filtration rate (eGFR) for ninety-nine type 2 diabetes mellitus (T2DM) patients. Forty nine (49) patients with T2DM were in the cinnamon group whereas 50 were in the placebo group. All participants received either a cinnamon or placebo capsule daily for the 60-day study period. At the end of the study, median glucose, TG, TG/HDL-C ratio, and BP were significantly decreased (p \ 0.005) whereas HDL-C and eGFR levels were significantly increased (p \ 0.005) in the cinnamon supplementation group. Interestingly, the study also revealed reduction of HbA1c levels after the 60-day study period. In the placebo group, glucose, TG levels tended to increase and HDL-C levels tended to decrease whereas systolic and diastolic BP, HbA1c, and BUN CT were significantly increased and eGFR was significantly reduced (p \ 0.005). Cinnamon supplementation reduced plasma glucose, HbA1c, triglyceride, TG/HDL-C ratio, and BP and increased HDL-C levels and eGFR in subjects with T2DM. Cinnamon supplementation may be beneficial for those with T2DM to prevent and control diabetic complications.

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Section: Discussionsupporting

confidence: 55%

Effect of cinnamon supplementation on glucose, lipids levels, glomerular filtration rate, and blood pressure of subjects with type 2 diabetes mellitus

Sengsuk

Sanguanwong²,

Tangvarasittichai

et al. 2015

Diabetol Int

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“…In addition to its culinary uses, cinnamon has been used in traditional herbal medicine to treat different health conditions (Gruenwald et al, 2010). Some studies showed that cinnamon extracts and its constituents also effective in the treatment of cancer (Nishida et al, 2003), insecticidal (Yang et al 2005), hypotensive (Preuss et al, 2006), antioxidant and antimutagenic activities (Jayaprakasha et al, 2007), cholesterol-lowering effects (Subash Babu et al, 2007), antimicrobial action (Carmo et al, 2008) and anti-inflammatory effect (Tung et al, 2008). The liver is the largest internal organ in the body and played a very important role in the detoxification of harmful and toxic substances.…”

Section: Introductionmentioning

confidence: 99%

Paracetamol induced hepatic toxicity and amelioration by cinnamon in rats

Elkomy¹,

Aboubakr

Soliman³

et al. 2016

IJPT

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The study was designed to evaluate the hepato-protective activity of aqueous extract of cinnamon in acute experimental liver injury induced by paracetamol. Twenty four male albino rats were randomly divided into four groups (six rats in each). Group I rats received distilled water for 15 days and served as a vehicle control. The animals in the group II were given single oral administration of paracetamol (1 g/kg), 1 h after last distilled water administration and acts as paracetamol toxic control group. Groups III and IV received aqueous extract of cinnamon (200 and 400 mg/kg bwt), respectively, once daily for 15 consecutive days followed by a single oral administration of paracetamol (1 g/kg), 1 h after the last cinnamon dose administration. The degree of hepatoprotection was measured using liver enzymes (Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), bilirubin, albumin, and lipid profile levels. Also, histopathological examinations of liver were done. The significantly disturbed liver functions by paracetamol toxicity were restored to nearly normal values by administration of cinnamon. Also, the change in biochemical parameters in groups received paracetamol alone was modified towards the normal values in groups given paracetamol and cinnamon. Histopathological effect of paracetamol on liver was also markedly decreased by co-administration of cinnamon. Our findings concluded that cinnamon aqueous extracts possessed hepatoprotective activity against paracetamol induced hepatic toxicity in rats.

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“…The antihypertensive action of cinnamon extract was successfully demonstrated in both spontaneously hypertensive rats [14] and patients with metabolic syndrome (22 men and women treated with a 500-mg extract daily for 12 weeks) [15]. Moreover, triglyceride-lowering effects with cinnamon were observed in Wistar rats fed a high-fructose diet [16] and in some clinical trials.…”

Section: Presl (Lauraceae)mentioning

confidence: 83%

Plant derived therapeutics for the treatment of Metabolic Syndrome

Cefalu¹

2011

Planta Med

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Metabolic syndrome is defined as a set of coexisting metabolic disorders that increase an individual's likelihood of developing type 2 diabetes, cardiovascular disease and stroke. Medicinal plants, some of which have been used for thousands of years, serve as an excellent source of bioactive compounds for the treatment of metabolic syndrome because they contain a wide range of phytochemicals with diverse metabolic effects. In order for botanicals to be effectively used against metabolic syndrome, however, botanical preparations must be characterized and standardized through the identification of their active compounds and respective modes of action, followed by validation in controlled clinical trials with clearly defined endpoints. This review assesses examples of commonly known and partially characterized botanicals to describe specific considerations for the phytochemical, preclinical and clinical characterization of botanicals associated with metabolic syndrome.

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Whole Cinnamon and Aqueous Extracts Ameliorate Sucrose-Induced Blood Pressure Elevations in Spontaneously Hypertensive Rats

Cited by 82 publications

References 38 publications

Effect of cinnamon supplementation on glucose, lipids levels, glomerular filtration rate, and blood pressure of subjects with type 2 diabetes mellitus

Effect of cinnamon supplementation on glucose, lipids levels, glomerular filtration rate, and blood pressure of subjects with type 2 diabetes mellitus

Paracetamol induced hepatic toxicity and amelioration by cinnamon in rats

Plant derived therapeutics for the treatment of Metabolic Syndrome

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