Effect of cinnamon supplementation on glucose, lipids levels, glomerular filtration rate, and blood pressure of subjects with type 2 diabetes mellitus

Abstract

A randomized, double-blind, placebo-controlled trial was performed to investigate the effect of cinnamon supplementation on glucose, triglyceride (TG), and high density lipoprotein-cholesterol (HDL-C) levels, TG/HDL-C ratio, blood pressure (BP), and estimated glomerular filtration rate (eGFR) for ninety-nine type 2 diabetes mellitus (T2DM) patients. Forty nine (49) patients with T2DM were in the cinnamon group whereas 50 were in the placebo group. All participants received either a cinnamon or placebo capsule daily for the 60-day study period. At the end of the study, median glucose, TG, TG/HDL-C ratio, and BP were significantly decreased (p \ 0.005) whereas HDL-C and eGFR levels were significantly increased (p \ 0.005) in the cinnamon supplementation group. Interestingly, the study also revealed reduction of HbA1c levels after the 60-day study period. In the placebo group, glucose, TG levels tended to increase and HDL-C levels tended to decrease whereas systolic and diastolic BP, HbA1c, and BUN CT were significantly increased and eGFR was significantly reduced (p \ 0.005). Cinnamon supplementation reduced plasma glucose, HbA1c, triglyceride, TG/HDL-C ratio, and BP and increased HDL-C levels and eGFR in subjects with T2DM. Cinnamon supplementation may be beneficial for those with T2DM to prevent and control diabetic complications.

Cinnamon supplementation improves blood pressure in type 2 diabetic patients: A systematic review and meta-analysis of randomized controlled trials

“…Our results were also in line with the results of a study by Akilen et al as they demonstrated that cinnamon supplementation could significantly decrease SBP in diabetic patients [10]. Furthermore, our results also confirmed the results of a study by Sengsuk et al regarding the blood pressure-lowering effects of cinnamon [11].…”

“…It has also been suggested that it could be used as an herbal remedy for the treatment of several disorders including cardiovascular diseases, type 2 diabetes, chronic digestive difficulties, and Alzheimer's disease [8]. Some previous studies have reported that cinnamon supplementation can significantly reduce systolic and diastolic blood pressure in the subjects with type 2 diabetes mellitus [9][10][11]. The results of some other studies have not been consistent [12,13].…”

A tale of two cinnamons: A comparative review of the clinical evidence of Cinnamomum verum and C. cassia as diabetes interventions

“…Dosages were 1-3g per day, and durations of the trials ranged from 30 days to four months. Reduction in fasting blood glucose or other diabetes-related parameters were demonstrated in ten studies (C. cassia 1.5-6g per day for 40 days -four months, or C. verum 3g per day for 8 weeks) (Akilen et al, 2010;Azimi et al, 2014;Azimi et al, 2016;Crawford, 2009;Gullapalli et al, 2013;Khan et al, 2003;Lu et al, 2012;Mang et al, 2006;Sengsuk et al, 2016;Soni and Bhatnagar, 2009), and a study showed postprandial blood glucose decrease after 40-day administration of C. cassia (2g per day) (Soni and Bhatnagar, 2009).…”

“…Eight of these ten positive outcomes were from the 12 C. cassia studies (Akilen et al, 2010;Blevins et al, 2007;Crawford, 2009;Gullapalli et al, 2013;Hasanzade et al, 2013;Khan et al, 2003;Lu et al, 2012;Mang et al, 2006;Sengsuk et al, 2016;Soni and Bhatnagar, 2009;Suppapitiporn et al, 2006;Vanschoonbeek et al, 2006) and the remaining positive outcomes were two of the three C. verum studies (Azimi et al, 2014;Vafa et al, 2012). Furthermore, C. cassia 1.5-6g per day, aqueous extract 120-360 mg per day for 40 daysthree months, or C. verum 3g per day for eight weeks reduced triglyceride and LDL levels in T2DM patients (Khan et al, 2003;Lu et al, 2012;Sengsuk et al, 2016). Considering that body fat is a significant diabetes-associated risk factor for cardiovascular disease (Howard et al, 2000), C. cassia and C. verum may help prevent the development of vascular comorbidity in T2DM.…”

“…cassia (Akilen et al, 2010;Blevins et al, 2007;Crawford, 2009;Gullapalli et al, 2013; J o u r n a l P r e -p r o o f Hasanzade et al, 2013;Khan et al, 2003;Lu et al, 2012;Mang et al, 2006;Sengsuk et al, 2016;Soni and Bhatnagar, 2009;Suppapitiporn et al, 2006;Vanschoonbeek et al, 2006) (n=730) and three trials used C. verum (Azimi et al, 2014;Azimi et al, 2016;Vafa et al, 2012) (n=123). Dosages were 1-3g per day, and durations of the trials ranged from 30 days to four months.…”