A tale of two cinnamons: A comparative review of the clinical evidence of Cinnamomum verum and C. cassia as diabetes interventions

Shinjyo, Noriko; Waddell, Guy; Green, Julia

doi:10.1016/j.hermed.2020.100342

Cited by 17 publications

(7 citation statements)

References 89 publications

(174 reference statements)

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“…Such properties increase glucose uptake by activating the insulin receptor's autophosphorylation, glycogen synthase activity, and insulin receptor kinase activity (3). Cinnamon is a prophylactic supplement of insulin resistance, metabolic syndrome, T2DM, hyperlipidemia, and arthritis in the market (29). More than 250 species of genus Cinnamomum (Lauraceae) are identified, and C. cassia and C. zeylanicum are the main varieties with applications in medicine (3).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Combined Herbal Capsule on Glycemic Indices and Lipid Profile in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Clinical Trial

Ghafarzadegan

Javaheri

Asgari

et al. 2021

Jundishapur J Nat Pharm Prod

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Objectives: The present study aimed to investigate the potential effects of the combined herbal capsule (CHC), as a nutritional supplement, on glycemic indices (GIs) and lipid profile (LP) of patients with type 2 diabetes mellitus (T2DM). Methods: Following a randomized, single-blind, placebo-controlled clinical trial, the current study was conducted on 80 cases with T2DM who were randomly assigned into two groups of treatment (CHCs; n = 40) and control (placebo; n = 40). Both groups received the intervention (500 mg capsules) twice a day for three months, without changes in the previous dose of oral anti-hyperglycemic drugs. The GI and LP levels were measured before the intervention and three months later to investigate the potential efficacy of the interventions. Results: For those in the intervention group, the mean GI [i.e., fasting blood sugar, two hours postprandial (2hpp), and HbA1c] was significantly different after 3 months (P < 0.05). The GI- and LP-related outcomes (TG, LDL-C except for TC) were improved after 3-month of receiving the intervention compared to the control group; however, the observed improvement was no statistically significant (P > 0.05). The HDL-C level was also significantly improved in the intervention group compared to the control group (P < 0.05). Conclusions: This study demonstrated that receiving CHCs could improve GI and LP levels (TG, LDL-C, and HDL-C, except for TC), which indicates its potential to control T2DM. Moreover, no significant side effect was observed in the intervention group. It can be argued that the use of CHCs, as adjuvant therapy, in combination with conventional hypoglycemic and lipid-lowering drugs, as well as following a modified lifestyle, not only can signiﬁcantly enhance glycemic control but also may prevent T2DM complications.

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Section: Discussionmentioning

confidence: 99%

The Effect of Combined Herbal Capsule on Glycemic Indices and Lipid Profile in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Clinical Trial

Ghafarzadegan

Javaheri

Asgari

et al. 2021

Jundishapur J Nat Pharm Prod

View full text Add to dashboard Cite

show abstract

“…It is important to point out that the main complications of diabetes are cardiovascular diseases and disorders, so cinnamon could help mitigate the appearance or development of both diseases, even if the former is already present (Mahmoodnia et al, 2017). Most clinical studies are on C. cassia, which in doses of 3 to 6 g per day could improve glucose metabolism in people with DM2 (Shinjyo, Waddell, & Green, 2020).…”

Section: Cardiovascular Protective Effect Of Cinnamonmentioning

confidence: 99%

Cardiovascular protective effect of cinnamon and its major bioactive constituents: An update

Das

Gonçalves

Heredia

et al. 2022

Journal of Functional Foods

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“…Garlic was highly prized in ancient Egyptian, Greek, and Chinese cultures as a food and medicinal (169,170). It has been studied clinically for a variety of illnesses, including hypertension, hypercholesterolemia, diabetes, common cold, and cancer prevention (171)(172)(173)(174)(175)(176)(177)(178). This plant has antibacterial, antifungal, antioxidant, immune system stimulant, and anti-parasitic properties (159,162,176).…”

Section: Garlic: Allicinmentioning

confidence: 99%

Chemoprevention effect of the Mediterranean diet on colorectal cancer: Current studies and future prospects

et al. 2022

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Colorectal cancer (CRC) is the third most common cancer and the second most deadly cancer worldwide. Nevertheless, more than 70% of CRC cases are resulted from sporadic tumorigenesis and are not inherited. Since adenoma-carcinoma development is a slow process and may take up to 20 years, diet-based chemoprevention could be an effective approach in sporadic CRC. The Mediterranean diet is an example of a healthy diet pattern that consists of a combination of nutraceuticals that prevent several chronic diseases and cancer. Many epidemiological studies have shown the correlation between adherence to the Mediterranean diet and low incidence of CRC. The goal of this review is to shed the light on the anti-inflammatory and anti-colorectal cancer potentials of the natural bioactive compounds derived from the main foods in the Mediterranean diet.

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A tale of two cinnamons: A comparative review of the clinical evidence of Cinnamomum verum and C. cassia as diabetes interventions

Abstract: A tale of two cinnamons: a comparative review of the clinical evidence of Cinnamomum verum and C.cassia as diabetes interventions Shinjiyo, N., Waddell, G. and Green, J.

Cited by 17 publications

References 89 publications

The Effect of Combined Herbal Capsule on Glycemic Indices and Lipid Profile in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Clinical Trial

The Effect of Combined Herbal Capsule on Glycemic Indices and Lipid Profile in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Clinical Trial

Cardiovascular protective effect of cinnamon and its major bioactive constituents: An update

Chemoprevention effect of the Mediterranean diet on colorectal cancer: Current studies and future prospects

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