Whole‐brain microcirculation detection after ischemic stroke based on swept‐source optical coherence tomography

Liu, Jian; Ding, Ning; Yu, Yao; Liu, Lanxiang; Yuan, Xincheng; Lv, Hongyu; Zhao, Yuqian; Ma, Zhenhe

doi:10.1002/jbio.201900122

Cited by 12 publications

(9 citation statements)

References 37 publications

(37 reference statements)

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“…In our previous study, 22 we found that blood flow immediately decreased after ET-1 injection. But, at this time, OAC did not change significantly.…”

Section: -5mentioning

confidence: 64%

“…A wide FoV SS-OCT system, set up in our previous work, 31 was used in this study, as shown in Fig. 1.…”

Section: Systemmentioning

confidence: 99%

“…In order to better monitor the development of cerebral edema after stroke, it is necessary to provide sufficient imaging field-of-view (FoV) for the entire cortex. The swept-source optical coherence tomography (SS-OCT) developed in recent years has proven to have higher spectral resolution 22 and greater light intensity 23 than traditional SD-OCT. Therefore, SS-OCT has been widely used in clinical settings in areas, in areas such as ophthalmology [24][25][26] and dermatology, 27 and for imaging oral and nasal cavity tissues.…”

Section: Introductionmentioning

confidence: 99%

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Cerebral edema detection in vivo after middle cerebral artery occlusion using swept-source optical coherence tomography

Liu

et al. 2019

Neurophoton.

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edema detection in vivo after middle cerebral artery occlusion using swept-source optical coherence tomography,"Abstract. Cerebral edema is a severe complication of ischemic cerebrovascular disease, which can lead to microcirculation compression resulting in additional ischemic damage. Real-time and continuous in vivo imaging techniques for edema detection are of great significance to basic research on cerebral edema. We attempted to monitor the cerebral edema status in rats with middle cerebral artery occlusion (MCAO) over time, using a wide field-of-view swept-source optical coherence tomography (SS-OCT) system. Optical attenuation coefficients (OACs) were calculated by an optimized depth-resolved estimation method, and en face OAC maps covering the whole cortex were obtained. Then, the tissue affected by edema was segmented from the OAC maps, and the cortical area affected by edema was estimated. Both magnetic resonance image (MRI) and brain water content measurements were used to verify the presence of cerebral edema. The results showed that the average OAC of the ischemic area gradually decreased as cerebral edema progressed, and the edema area detected by SS-OCT had high similarity in position and shape to that obtained by MRI. This work extends the application of OCT and provides an option for detecting cerebral edema in vivo after ischemic stroke. © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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“…In our previous study, 22 we found that blood flow immediately decreased after ET-1 injection. But, at this time, OAC did not change significantly.…”

Section: -5mentioning

confidence: 64%

“…A wide FoV SS-OCT system, set up in our previous work, 31 was used in this study, as shown in Fig. 1.…”

Section: Systemmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cerebral edema detection in vivo after middle cerebral artery occlusion using swept-source optical coherence tomography

Liu

et al. 2019

Neurophoton.

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“…A wide-range SS-OCT system was selected for the experiments [37]. The light source used is a swept-source with a center wavelength of 1310 nm and a bandwidth of 100 nm.…”

Section: Ss-oct Systemmentioning

confidence: 99%

Evaluation of Mannitol Intervention Effects on Ischemic Cerebral Edema in Mice Using Swept Source Optical Coherence Tomography

Meng

Tian

et al. 2022

Photonics

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Cerebral edema is a serious complication of ischemic cerebrovascular disease and mannitol is a commonly used dehydrating agent for relieving cerebral edema. However, the edema state and surrounding vascular perfusion level during mannitol treatment remains unclear, which affects the clinical application of the medicine. In this paper, we demonstrated the role of swept-source optical coherence tomography (OCT) in the evaluation of mannitol efficacy using mouse models. The OCT-based angiography and attenuation imaging technology were used to obtain the cerebral vascular perfusion level and cerebral edema state at different times. Vascular parameters and edema parameters were quantified and compared. Experimental results show that mannitol can significantly reduce the water content in the central region of edema, effectively inhibiting the rapid growth of the edema area, and restoring cerebral blood flow. On average, the edema area decreased by 33% after 2 h, and the vascular perfusion density increased by 12% after 5 h. This work helps to provide a valuable theoretical basis and research ideas for the clinical treatment of cerebral edema.

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“…In this article, an image registration algorithm based on constrained demons introduced in our previous research was used [32]. In this article, an image registration algorithm based on constrained demons introduced in our previous research was used [32].…”

Section: Motion Artifact Eliminationmentioning

confidence: 99%

Simultaneous detection of cerebral blood perfusion and cerebral edema using swept‐source optical coherence tomography

Liu

et al. 2019

Journal of Biophotonics

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The progression of ischemic cerebral edema (CE) is closely related to the level of cerebral blood perfusion (CBP) and affects each other.Simultaneous detection of CBP and CE is helpful in understanding the mechanisms of ischemic CE development. In this article, a wide field of view swept-source optical coherence tomography system was used to detect CE status and CBP levels simultaneously in middle cerebral artery occlusion rats. Images reflecting these two physiological states can be reconstructed with only one C-scan. We quantify these two physiological states into four parameters, which contain two vascular parameters (vascular displacement distance and vascular perfusion density) and two edema parameters (optical attenuation coefficient and edema area). The association between the two vascular parameters and the two edema parameters was analyzed. The results show that there is a strong linear relationship between blood flow parameters and edema parameters. This work provides a new option for CE in vivo detection, and is very likely to play an important role in the development of relevant drugs or in selection of treatment options. K E Y W O R D Scerebral blood perfusion, cerebral edema, middle cerebral artery occlusion, optical attenuation coefficient, swept-source optical coherence tomography

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Whole‐brain microcirculation detection after ischemic stroke based on swept‐source optical coherence tomography

Cited by 12 publications

References 37 publications

Cerebral edema detection in vivo after middle cerebral artery occlusion using swept-source optical coherence tomography

Cerebral edema detection in vivo after middle cerebral artery occlusion using swept-source optical coherence tomography

Evaluation of Mannitol Intervention Effects on Ischemic Cerebral Edema in Mice Using Swept Source Optical Coherence Tomography

Simultaneous detection of cerebral blood perfusion and cerebral edema using swept‐source optical coherence tomography

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