Whole-body MR-DWIBS vs. [18F]-FDG-PET/CT in the study of malignant tumors: a retrospective study

Cafagna, D; Rubini, Giuseppe; Iuele, Francesca; Maggialetti, Nicola; Notaristefano, Antonio; Pinto, Dario; Asabella, Artor Niccoli; Palmiotti, Gennaro; Lasciarrea, Maurilia; Maggialetti, A.

doi:10.1007/s11547-011-0708-3

Cited by 26 publications

(14 citation statements)

References 10 publications

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“…To our knowledge, few studies have evaluated the relationship between ADC and SUV in cancer patients (16)(17)(18). The aim of the present study was to retrospectively assess the correlation between the minimum ADC (ADC min ) on DWI and maximum SUV (SUV max ) values from FDG PET-CT in rectal cancer.…”

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confidence: 99%

Correlation of minimum apparent diffusion coefficient with maximum standardized uptake on fluorodeoxyglucose PET-CT in patients with rectal adenocarcinoma

Erden²,

No³

et al. 2013

Diagn Interv Radiol

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ABDOMINAL IMAGINGORIGINAL ARTICLE PURPOSE The aim of this study was to retrospectively assess the correlation between minimum apparent diffusion coefficient (ADC min ) values obtained from diffusion-weighted magnetic resonance imaging (MRI) and maximum standardized uptake values (SUV max ) obtained from positron emission tomography-computed tomography (PET-CT) in rectal cancer. MATERIALS AND METHODSForty-one patients with pathologically confirmed rectal adenocarcinoma were included in this study. For preoperative staging, PET-CT and pelvic MRI with diffusion-weighted imaging were performed within one week (mean time interval, 3±1 day). For ADC measurements, the region of interest (ROI) was manually drawn along the border of each hyperintense tumor on b=1000 s/mm 2 images. After repeating this procedure on each consecutive tumor-containing slice to cover the entire tumoral area, ROIs were copied to ADC maps. ADC min was determined as the lowest ADC value among all ROIs in each tumor. For SUV max measurements, whole-body images were assessed visually on transaxial, sagittal, and coronal images. ROIs were determined from the lesions observed on each slice, and SUV max values were calculated automatically. The mean values of ADC min and SUV max were compared using Spearman's test. RESULTSThe mean ADC min was 0.62±0.19×10 -3 mm 2 /s (range, 0.368-1.227×10 -3 mm 2 /s), the mean SUV max was 20.07±9.3 (range, 4.3-49.5). A significant negative correlation was found between ADC min and SUV max (r=-0.347; P = 0.026). CONCLUSIONThere was a significant negative correlation between the ADC min and SUV max values in rectal adenocarcinomas. D iffusion-weighted imaging (DWI) is a widely used technique for disease evaluation in oncology (1, 2). In rectal cancer, the applications of DWI include tumor detection, tumor characterization, distinguishing tumor tissue from nontumor tissue, and monitoring and predicting treatment response (3-8). For local staging of rectal cancer, adding DWI to conventional magnetic resonance imaging (MRI) yields better identification of tumor borders and locoregional lymph nodes than conventional MRI alone (9, 10).The apparent diffusion coefficient (ADC) map obtained from DWI shows the freedom of water diffusion, and values calculated on the map are useful parameters in tissue characterization. By performing diffusion-weighted (DW) MRI with at least two diffusion weightings, or b values, the differential signal attenuation at different b values can be used to calculate the ADC (2). Regardless of the tumor type and location, the ADC values reflect tumor morphology, including the cellular density, integrity of cell membrane, and nuclear-to-cytoplasm ratio (11,12).Positron emission tomography/computed tomography (PET-CT) has become a crucial method in cancer imaging, both for diagnosis and staging, as well as for offering prognostic information based on tumor response. In PET-CT, the standardized uptake value (SUV) is a measure of fluorodeoxyglucose (FDG) uptake, which has been shown to be helpful in estab...

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confidence: 99%

Correlation of minimum apparent diffusion coefficient with maximum standardized uptake on fluorodeoxyglucose PET-CT in patients with rectal adenocarcinoma

Erden²,

No³

et al. 2013

Diagn Interv Radiol

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“…The negative results in the present study may be due to the biological characteristics and pathological features of the tumor (24,25). For instance, the glucose metabolism may have been low in the RCC of our patient (26). Notably, DWIBS/T2 provided positive diagnosis for RCC that was negative on PET/CT imaging.…”

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confidence: 51%

Comparison of DWIBS/T2 image fusion and PET/CT for the diagnosis of cancer in the abdominal cavity

Tomizawa

Shinozaki

Uchida

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Fusion images of diffusion-weighted whole-body imaging with background body signal suppression and T2-weighted image (DWIBS/T2) demonstrate a strong signal for malignancies, with a high contrast against the surrounding tissues, and enable anatomical analysis. In the present study, DWIBS/T2 was compared with 18 F-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography/computed tomography (PET/CT) for diagnosing cancer in the abdomen. Patient records, including imaging results of examination conducted between November 2012 and May 2014, were analyzed retrospectively. In total, 10 men (age, 73.6±9.6 years) and 8 women (age, 68.9±7.1 years) were enrolled into the current study. Of the enrolled patients, 2 were diagnosed with hepatocellular carcinoma, 1 with cholangiocellular carcinoma, 1 with liver metastasis, 2 with pancreatic ductal adenocarcinoma, 1 with renal cell carcinoma and 1 with malignant lymphoma. Benign lesions were also analyzed, including adenomyomatosis of the gallbladder (5 patients), intraductal papillary mucinous neoplasm (4 patients) and right adrenal adenoma (1 case). All the patients with cancer showed positive results on DWIBS/T2 images. However, only 7 out of 8 patients were positive with PET/CT. One patient with right renal cellular carcinoma was positive with DWIBS/T2, but negative with PET/CT. All the patients with benign lesions were negative with DWIBS/T2 and PET/CT. In conclusion, DWIBS/T2 was more sensitive in diagnosing cancer of organs in the abdominal cavity compared with PET/CT. Furthermore, negative results with DWIBS/T2 and PET/CT were useful for the diagnosis of benign lesions, such as adenomyomatosis of the gallbladder and intraductal papillary mucinous neoplasm.

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“…Confronting results have been reported by Cafagna et al who conducted a retrospective study in detection of metastasis including different types of tumors and concluded that 18FDG-PET/CT remained a better choice in identifying bone metastases [15]. A.…”

Section: Discussionmentioning

confidence: 78%

Retrospective comparative study between 3T WB-MRI including WB-DWI and 18F-FDG-PET/CT in detection of metastatic disease

Tanaka¹,

Nakanishi²,

Ueda³

et al. 2017

Cancer Rep Rev

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Purpose: To retrospectively compare the diagnostic accuracy of 18F-FDG-PET/CT (PET-CT) and WB-MRI with WB-DWI (WB-MRI) in various types of metastatic diseases. Materials and methods:There were 26 patients who underwent WB-MRI and PET-CT within a period of one month. The WB-MRI protocols were: sagittal T1WI (Turbo Spin Echo) with TR/TE: 600/ 9.4 (msec), STIR with TR/ TE: 6000/85/240 (msec), coronal T1WI (FLASH) with TR/TE of 120/2.46 (msec) and axial DWI (b-0 and 800) based on STIR with TR/TE/TI of 14000/60/240 (msec). Three radiologists with various lengths of experience were assigned to review the WB-MRI images. The PET-CT reports were reviewed by radiologists with more than 10 years of experience in diagnostic PET-CT images. All patients had a follow-up of more than 6 months by MRI, computed tomography (CT) or PET-CT.Results: A total of 124 gold standard malignant lesions were identified. Regarding WB-MRI, the sensitivity was 68-78% (p=0.059-1.00) and the positive predicted value was 76-84%. With PET-CT, 98 lesions were detected correctly in total and the sensitivity and positive predictive values were 79% and 65%. Concerning only skeletal metastasis, the number of gold standard lesions was 80 in total. Regarding WB-MRI, the sensitivity was 85-93% (p=0.002-0.02) and the positive predicted value was 79-95%. With PET-CT, 61 lesions were detected correctly in total and the sensitivity and positive predictive values were 76% (61/80), 75% (61/81) respectively Conclusion: Although PET-CT and WB-MRI yielded similar overall results in detection of malignant lesions, the performance of WB-MRI in detection of bone metastasis was significantly higher.

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Whole-body MR-DWIBS vs. [18F]-FDG-PET/CT in the study of malignant tumors: a retrospective study

Cited by 26 publications

References 10 publications

Correlation of minimum apparent diffusion coefficient with maximum standardized uptake on fluorodeoxyglucose PET-CT in patients with rectal adenocarcinoma

Correlation of minimum apparent diffusion coefficient with maximum standardized uptake on fluorodeoxyglucose PET-CT in patients with rectal adenocarcinoma

Comparison of DWIBS/T2 image fusion and PET/CT for the diagnosis of cancer in the abdominal cavity

Retrospective comparative study between 3T WB-MRI including WB-DWI and 18F-FDG-PET/CT in detection of metastatic disease

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