Whole-blood viscosity and the insulin-resistance syndrome

Høieggen, Aud; Fossum, Eigil; Moan, Andreas; Enger, E; Kjeldsen, Sverre E.

doi:10.1097/00004872-199816020-00011

Cited by 72 publications

(56 citation statements)

References 46 publications

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“…9 The hemodynamic hypothesis of insulin resistance 10 suggests peripheral structural vascular changes and rarefaction to be determinants of insulin resistance. In support of this hypothesis, we have previously shown a positive correlation between insulin resistance and determinants of peripheral blood flow, such as calculated 4 and directly measured 3 WBV and structural vascular changes as assessed by MFVR. 8 Furthermore, in these young men, insulin resistance is closely and positively related to sympathetic activity and BP responses during mental stress, 8,11 and BP responses during mental stress correlate closely and positively with MFVR.…”

supporting

confidence: 54%

“…This measurement has a CV of 7% in our laboratory. Left ventricular mass was calculated with the equation LVMϭ 1.04[(IVSTϩLVIDϩPWT) 3 ϪLVID 3 ]Ϫ13.6 g, where IVST is interventricular septal thickness, LVID is left ventricular internal dimension, and PWT is posterior wall thickness. Mean myocardial thickness and left ventricular mass are referred to as cardiac dimensions.…”

Section: Echocardiographymentioning

confidence: 99%

“…2 In our earlier studies of young men, recruited from the highest blood pressure (BP) percentiles during the compulsory military draft session in Oslo, we showed a positive correlation between insulin resistance and cardiovascular risk factors such as lipids 3 and body weight. 4 Physical fitness is a determinant of insulin sensitivity, 5-7 which we previously have not included in our studies of these apparently healthy 18-year-old men.…”

mentioning

confidence: 96%

“…In the present study, we therefore aimed to relate physical fitness to glucose disposal rate (GDR) in this well-described population of young men and to assess a possible mechanism for a relationship; ie, whether there is a direct relationship or whether it is influenced or determined by other correlates of GDR, such as lipids, body weight, minimal forearm vascular resistance (MFVR), 8 or whole blood viscosity (WBV). 3,4 We assessed physical fitness as the total work performed during an ergometer bicycle exercise test divided by body weight because this technique for assessing physical fitness rather strongly predicts cardiovascular mortality in healthy, middle-aged Norwegian men. 9 The hemodynamic hypothesis of insulin resistance 10 suggests peripheral structural vascular changes and rarefaction to be determinants of insulin resistance.…”

mentioning

confidence: 99%

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Insulin Sensitivity Is Related to Physical Fitness and Exercise Blood Pressure to Structural Vascular Properties in Young Men

et al. 1999

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Abstract-Insulin resistance is related to physical inactivity, which is a risk factor for cardiovascular disease and death.Moreover, blood pressure responses during the first 6 minutes of an exercise test (600 kilo/pound/meter [kpm] per min) are more predictive for cardiovascular morbidity and mortality than blood pressure at rest, which could reflect that exercise blood pressure correlates more closely to peripheral structural vascular changes than casual blood pressure. We have recently shown a correlation between insulin resistance and minimal forearm vascular resistance (MFVR) in young men recruited from the highest blood pressure percentiles during a military draft session. In the present study, we tested the hypotheses that insulin sensitivity relates to physical fitness and that blood pressure responses during an exercise test relate to peripheral structural vascular changes in these men; we also tested whether these findings were interrelated. We assessed insulin sensitivity and physical fitness in 27 young men randomly selected from the cohort having a blood pressure of 140/90 mm Hg or higher during the compulsory military draft session in Oslo. Insulin sensitivity correlated with physical fitness (rϭ0.58, Pϭ0.002). Systolic blood pressure after 6 minutes of exercise (600 kpm/min) correlated with MFVR (rϭ0.46, Pϭ0.015). MFVR and physical fitness independently explained 60% of the variation in insulin sensitivity, and MFVR independently explained 19% of the variation of systolic blood pressure after 6 minutes of exercise. In conclusion, insulin sensitivity is related to physical fitness and exercise blood pressure to structural vascular properties in these young men. (Hypertension. 1999;33:781-786.)Key Words: insulin resistance Ⅲ exercise Ⅲ blood pressure Ⅲ physical fitness Ⅲ vascular structure I nsulin resistance 1 has been proposed as the metabolic link between non-insulin-dependent diabetes mellitus, hypertension, and atherosclerotic cardiovascular disease. 2 In our earlier studies of young men, recruited from the highest blood pressure (BP) percentiles during the compulsory military draft session in Oslo, we showed a positive correlation between insulin resistance and cardiovascular risk factors such as lipids 3 and body weight. 4 Physical fitness is a determinant of insulin sensitivity, 5-7 which we previously have not included in our studies of these apparently healthy 18-year-old men. In the present study, we therefore aimed to relate physical fitness to glucose disposal rate (GDR) in this well-described population of young men and to assess a possible mechanism for a relationship; ie, whether there is a direct relationship or whether it is influenced or determined by other correlates of GDR, such as lipids, body weight, minimal forearm vascular resistance (MFVR), 8 or whole blood viscosity (WBV). 3,4 We assessed physical fitness as the total work performed during an ergometer bicycle exercise test divided by body weight because this technique for assessing physical fitness rather strongly predic...

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supporting

confidence: 54%

Section: Echocardiographymentioning

confidence: 99%

mentioning

confidence: 96%

mentioning

confidence: 99%

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Insulin Sensitivity Is Related to Physical Fitness and Exercise Blood Pressure to Structural Vascular Properties in Young Men

et al. 1999

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“…3,4 On the other hand we know that in obese subjects, characterized by an alteration of insulin sensitivity, a hyperviscosity condition is present and that in these subjects weight reduction especially affects plasma viscosity and not the other haemorheological determinants. 5,6 We examined, in a group of subjects with metabolic syndrome (MS) defined according to the WHO criteria, 7 the relationship between plasma viscosity and the parameters reflecting insulin-resistance.…”

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Plasma viscosity and insulin resistance in metabolic syndrome

Caimi¹,

Sinagra

Scarpitta

et al. 2001

Int J Obes

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There are some reports concerning the relationship between insulin sensitivity and whole-blood viscosity calculated 1,2 or measured. 3,4 On the other hand we know that in obese subjects, characterized by an alteration of insulin sensitivity, a hyperviscosity condition is present and that in these subjects weight reduction especially affects plasma viscosity and not the other haemorheological determinants. 5,6 We examined, in a group of subjects with metabolic syndrome (MS) defined according to the WHO criteria, 7 the relationship between plasma viscosity and the parameters reflecting insulin-resistance.In 19 subjects with MS (nine men and 10 women; mean age 49.0 AE 10.2 y body mass index (BMI) 33.3 AE 4.5 kg=m 2 waist -hip ratio (WHR) 0.915 AE 0.071; systolic blood pressure 135.8 AE 19.3 mmHg; diastolic blood pressure 83.4 AE 6.2 mmHg; fasting blood glucose level 9.12 AE 3.56 mmol=l; Hb Alc 7.06 AE 1.84%; microalbuminuria 5.7 AE 3.2 ng=min), the insulin sensitivity was assessed by performing a euglycaemic hyperinsulinaemic clamp and considering the glucose disposal (M), expressed as mg=kg=min and calculated on the basis of the glucose amount infused, and the glucose metabolic clearance rate (MCR), expressed as ml=kg=min and calculated by dividing the amount of metabolized glucose (M) by the plasma glucose concentration. In these subjects, plasma viscosity (PV) was determined on fasting venous blood anticoagulated with ethylenediaminetetracetate (EDTA), at the shear rate of 450 s 71 , using the viscosimeter Wells-Brookfield 1 2 LVT. Between normal subjects and patients with MS there was a significant difference in plasma viscosity (n ¼ 1.24 AE 0.08, MS ¼ 1.40 AE 0.10, P < 0.001). This haemorheological parameter was negatively correlated to the values of M (r 2 ¼ 0.398, P < 0.01) and MCR (r 2 ¼ 0.370, P < 0.01).We then observed that the trend of the PV is related to both parameters reflecting the insulin-resistance, revealing how its behaviour is influenced by the degree of resistance. Besides considering the PV another component of the MS, our interest in underlining these relationships was motivated by the consideration that insulin-resistance and PV impair the microhaemodynamic pattern, and this impairment may be one of the links not only between insulin-resistance and the principal features (diabetes mellitus, hypertension, obesity etc) of MS, but also between insulin-resistance and the vascular complications accompanying this syndrome.

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Sympathoadrenal Reactivity to Stress as a Predictor of Cardiovascular Risk Factors

Flaa

Rostrup

Kjeldsen

et al. 2018

Updates in Hypertension and Cardiovascular Protection

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Whole-blood viscosity and the insulin-resistance syndrome

Cited by 72 publications

References 46 publications

Insulin Sensitivity Is Related to Physical Fitness and Exercise Blood Pressure to Structural Vascular Properties in Young Men

Insulin Sensitivity Is Related to Physical Fitness and Exercise Blood Pressure to Structural Vascular Properties in Young Men

Plasma viscosity and insulin resistance in metabolic syndrome

Sympathoadrenal Reactivity to Stress as a Predictor of Cardiovascular Risk Factors

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