Who are the individuals diagnosed with epilepsy using the Public Health System in the city of Pelotas, southern Brazil?

Häfele, César Augusto; Freitas, Matheus Pintanel; Gervini, Bianca Lamas; Carvalho, Raquel Machado de; Rombaldi, Aírton José

doi:10.1016/j.yebeh.2017.10.015

Cited by 9 publications

(11 citation statements)

References 44 publications

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“…Additionally, antiepileptic drugs can synergistically exacerbate the deficits arising from that neurological pathophysiology 3 . Our previous study reported that carbamazepine, phenobarbital, and valproate were the most used antiepileptic drugs among the studied population 12 . Valproate was associated with cognitive impairment regardless of seizure frequency among adults with epilepsy 44 .…”

Section: Discussionmentioning

confidence: 90%

“…Recruitment was conducted between June 6, 2019 and October 30, 2019 by social media, in local press, at Public Health System services, among participants from a previous descriptive study, 12 and by identification on records from the Neurology Outpatient Clinic of the Medical School, Federal University of Pelotas. Eligible patients were between 18 and 60 years old, of both sexes, sedentary, and diagnosed with epilepsy (confirmed by a physician).…”

Section: Methodsmentioning

confidence: 99%

“…On the other hand, 65% of people with epilepsy are physically inactive 12 (ie, do not reach 150 minutes or more of moderate‐to‐vigorous physical activity per week 13 ). Besides being positively associated with quality of life, a higher level of physical activity was associated with fewer side effects from antiepileptic medication 14 .…”

Section: Introductionmentioning

confidence: 99%

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Effect of combined physical training on cognitive function in people with epilepsy: Results from a randomized controlled trial

et al. 2020

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Objective: To examine the effect of 12-week exercise program on cognitive function in people with epilepsy. Methods: Twenty-one physically inactive subjects were randomized into two groups: the exercise group (EG) or the control group (CG). EG performed 12 weeks of combined physical training. CG was advised to maintain usual daily activities. EG received a structured, individually supervised exercise program with two 60-minute sessions per week. Each session included warmup (5-minutes), aerobic (15-20 minutes at 14-17 on Borg scale), strength (2-3 sets, 10-15 repetitions), and 5-minute active stretches. Sociodemographic characteristics, clinical information, memory (Digit Span Test [DST]), executive function (Trail Making Test [TMT] A and B), Stroop Color and Word Test, a verbal fluency task, global cognitive function (Montreal Cognitive Assessment [MoCA]), anthropometric measurements (weight, height, and hip and waist circumferences), cardiorespiratory fitness (maximal oxygen consumption [VO 2 max]), and strength (dynamometer) were measured at baseline and after the 12-week intervention.

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Section: Discussionmentioning

confidence: 90%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of combined physical training on cognitive function in people with epilepsy: Results from a randomized controlled trial

et al. 2020

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“…Participants must be diagnosed with epilepsy (confirmed by a physician who will be part of the research team) and be on antiepileptic drugs. The recruitment will be as follow: 1) people with epilepsy from the Neurology Outpatient Clinic of the Medical School -Federal University of Pelotas, participants from a previous descriptive study, 22 2) identification on records from the Neurology Outpatient Clinic of the Medical School -Federal University of Pelotas; and 3) dissemination by social media (e.g. Facebook, WhatsApp) and local press.…”

Section: Participants Recruitmentmentioning

confidence: 99%

Exercise program on the health of people with epilepsy: protocol of a randomized controlled trial study

Häfele

Rombaldi

Häfele

et al. 2020

Motriz: rev. educ. fis.

Self Cite

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“…Epilepsy is a common chronic neurological disease, and temporal lobe epilepsy (TLE) is one of the most common types of epilepsy in adult patients (Hauser et al, 1993;Jobst and Cascino, 2015). At present, there are approximately 70 million people worldwide suffering from epilepsy, most of whom are from low-and middle-income countries (Espinosa-Jovel et al, 2018;Hafele et al, 2018). Recurrent epileptic seizures seriously affect the physical and mental health of patients (Olesen et al, 2012;Wiglusz et al, 2018) and increase the public health burden on patients, family members and society.…”

Section: Introductionmentioning

confidence: 99%

Olfactomedin-3 Enhances Seizure Activity by Interacting With AMPA Receptors in Epilepsy Models

Tang

Wang

Zhang

et al. 2020

Front. Cell Dev. Biol.

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Background: OLFM3 (olfactomedin-3) is a member of the olfactomedin domain family, which has been found to stimulate the formation and adhesion of tight cell connections and to regulate cytoskeleton formation and cell migration. Differences in the gene coding for OLFM3 have been found between patients with epilepsy and controls. However, the exact role of OLFM3 in epilepsy has not been thoroughly investigated. Methods: Biochemical methods were used to assess OLFM3 expression and localization in the cortex of patients with temporal lobe epilepsy and in the hippocampus and cortex of epileptic mice. Electrophysiological recordings were used to measure the role of OLFM3 in regulating hippocampal excitability in a model of magnesium-free-induced seizure in vitro. Behavioral experiments were performed in a pentylenetetrazol (PTZ)-induced seizure model, and electroencephalograms (EEGs) were recorded in the chronic phase of the kainic acid (KA)-induced epilepsy model in vivo. OLFM3 and its interaction with AMPAR (α-amino-3-hydroxy-5-methyl-4isoxazole-propionic acid receptor) subunits were analyzed by co-immunoprecipitation. Results: The expression of OLFM3 was increased in the cortex of patients with temporal lobe epilepsy and in the hippocampus and cortex of epileptic mice compared with controls. Interestingly, lentivirus-mediated overexpression of OLFM3 in the hippocampus increased the susceptibility of mice to PTZ-induced seizures, and OLFM3 knockdown had the opposite effect. OLFM3 affected AMPAR currents in a brain-slice model of epileptiform activity induced by Mg2+-free medium. We found that OLFM3 co-immunoprecipitation with GluA1 and GluA2. Furthermore, downregulation or overexpression of OLFM3 in the hippocampus affected the membrane expression of GluA1 and GluA2 in epileptic mice. Conclusion: These findings reveal that OLFM3 may enhance seizure activity by interacting with GluA1 and GluA2, potentially indicating a molecular mechanism for new therapeutic strategies.

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Who are the individuals diagnosed with epilepsy using the Public Health System in the city of Pelotas, southern Brazil?

Cited by 9 publications

References 44 publications

Effect of combined physical training on cognitive function in people with epilepsy: Results from a randomized controlled trial

Effect of combined physical training on cognitive function in people with epilepsy: Results from a randomized controlled trial

Exercise program on the health of people with epilepsy: protocol of a randomized controlled trial study

Olfactomedin-3 Enhances Seizure Activity by Interacting With AMPA Receptors in Epilepsy Models

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