Whitening Effects of Marine<i>Pseudomonas</i>Extract

Kang, Hee Young; Yoon, Tae Jin; Lee, Gyong Jae

doi:10.5021/ad.2011.23.2.144

Cited by 18 publications

(11 citation statements)

References 6 publications

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“…Hyperpigmentation disorders, including melasma, freckles, and senile lentigines, are associated with abnormal accumulation of melanin, and these disorders have a psychosocial and cosmetic impact ( 25 ). Because OLME distinguishably inhibited melanin synthesis and dendrite development upon gross observation, quantitative analysis of the melanin synthetic ability of OLME in melan-a cells was conducted.…”

Section: Discussionmentioning

confidence: 99%

“…Melanin is one of the mostly widely distributed pigments, and is found in bacteria, fungi, plants, and animals. Increased production and accumulation of melanin is a characteristic of many skin diseases, including acquired hyperpigmentation, melasma, postinflammatory melanoderma, and solar lentigo ( 1 ). Melanin production occurs predominantly in a lysosome-like structure known as the melanosome in melanocytes ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

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Anti-Melanogenic Effect ofOenothera laciniataMethanol Extract in Melan-a Cells

2017

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We evaluated the antioxidant activity and anti-melanogenic effects of Oenothera laciniata methanol extract (OLME) in vitro by using melan-a cells. The total polyphenol and flavonoid content of OLME was 66.3 and 19.0 mg/g, respectively. The electron-donating ability, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical-scavenging activity, and superoxide dismutase (SOD)-like activity of OLME (500 μg/mL) were 94.5%, 95.6%, and 63.6%, respectively. OLME and arbutin treatment at 50 μg/mL significantly decreased melanin content by 35.5% and 14.2%, respectively, compared to control (p < 0.05). OLME and arbutin treatment at 50 μg/mL significantly inhibited intra-cellular tyrosinase activity by 22.6% and 12.6%, respectively, compared to control (p < 0.05). OLME (50 μg/mL) significantly decreased tyrosinase, tyrosinase-related protein-1 (TRP-1), TRP-2, and microphthalmia-associated transcription factor-M (MITF-M) mRNA expression by 57.1%, 67.3%, 99.0%, and 77.0%, respectively, compared to control (p < 0.05). Arbutin (50 μg/mL) significantly decreased tyrosinase, TRP-1, and TRP-2 mRNA expression by 24.2%, 42.9%, and 48.5%, respectively, compared to control (p < 0.05). However, arbutin (50 μg/mL) did not affect MITF-M mRNA expression. Taken together, OLME showed a good antioxidant activity and anti-melanogenic effect in melan-a cells that was superior to that of arbutin, a well-known skin-whitening agent. The potential mechanism underlying the anti-melanogenic effect of OLME was inhibition of tyrosinase activity and down-regulation of tyrosinase, TRP-1, TRP-2, and MITF-M mRNA expression.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti-Melanogenic Effect ofOenothera laciniataMethanol Extract in Melan-a Cells

2017

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“…A few studies are known to have been conducted on the skin whitening effects of marine bacteria; however, in opposition to common belief, it has been discovered that Pseudomonas produces methylene chloride that shows tyrosinase inhibitory activity (Kang et al, 2011). Moreover, some tyrosinase inhibitors (N-acyl dehydrotyrosine derivatives) have been reported from a gram-negative marine bacterium Thalassotalea sp.…”

Section: Seaweedmentioning

confidence: 99%

Marine derived tyrosinase inhibitors

Pilevneli¹,

Konuklugil²

2020

EgeJFAS

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The cosmetics industry has gained strong momentum all over the world in recent years and has become a growing and promising sector. As it is known, as in the pharmaceutical industry, the cosmetic industry has also turned into becoming marine resources by seeking new materials for its continuation to be more productive for the field. To serve this purpose, marine-derived substances are highly claimed to be an interesting as well as a fruitful source for the benefits of the cosmetics industry. In this respect, as known globally, anti-tyrosinase inhibitors used in skin whitening are obtained from a considerable number of marine organisms. In this regard, the main objective of this article is to summarize a highly significant number of natural products derived from marine sources such as algae, fungi, seaweeds and bacteria which are known to have shown anti-tyrosinase activity.

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“…So far, bacteria have been relatively less studied for their potential role in the production of skin-whitening compounds. However, a novel species of the marine bacteria Pseudomonas was found to produce methylene chloride, which reduced the pigmentation of human melanocytes and cultured skin cells by inhibiting the expression of tyrosinase [ 78 ]. In addition, tyrosinase inhibitors were reported from the marine bacterium Thalassotalea sp.…”

Section: Skin-whitening Productsmentioning

confidence: 99%

Marine Microbial-Derived Molecules and Their Potential Use in Cosmeceutical and Cosmetic Products

Corinaldesi

Barone

Marcellini³

et al. 2017

Marine Drugs

139

124

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The oceans encompass a wide range of habitats and environmental conditions, which host a huge microbial biodiversity. The unique characteristics of several marine systems have driven a variety of biological adaptations, leading to the production of a large spectrum of bioactive molecules. Fungi, fungi-like protists (such as thraustochytrids) and bacteria are among the marine organisms with the highest potential of producing bioactive compounds, which can be exploited for several commercial purposes, including cosmetic and cosmeceutical ones. Mycosporines and mycosporine-like amino acids, carotenoids, exopolysaccharides, fatty acids, chitosan and other compounds from these microorganisms might represent a sustainable, low-cost and fast-production alternative to other natural molecules used in photo-protective, anti-aging and skin-whitening products for face, body and hair care. Here, we review the existing knowledge of these compounds produced by marine microorganisms, highlighting the marine habitats where such compounds are preferentially produced and their potential application in cosmetic and cosmeceutical fields.

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Whitening Effects of MarinePseudomonasExtract

Cited by 18 publications

References 6 publications

Anti-Melanogenic Effect ofOenothera laciniataMethanol Extract in Melan-a Cells

Anti-Melanogenic Effect ofOenothera laciniataMethanol Extract in Melan-a Cells

Marine derived tyrosinase inhibitors

Marine Microbial-Derived Molecules and Their Potential Use in Cosmeceutical and Cosmetic Products

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